Mission Statement

The Asian Chemical Editorial Society (ACES) is an organization of 13 major chemical societies in Asia and the Pacific. It was founded in 2005 as a conglomeration of chemical societies with the mutual aim of creating a modern publishing forum for research in Asia and coordinating future publishing activities.

The participating societies share a commitment to scientific excellence, to publishing ethics, and to the highest standards in publication, which are the basis for the success of Chemistry—An Asian Journal and its associated journals.

Publications

Chemistry—An Asian Journal

A sister journal of Angewandte Chemie and Chemistry—A European Journal

Supporting Organizations: ChemPubSoc Europe, Gesellschaft Deutscher Chemiker (German Chemical Society, GDCh), Federation of Asian Chemical Societies (FACS).

Asian Journal of Organic Chemistry

A sister journal of the European Journal of Organic Chemistry

For the publication of the AsianJOC, ACES is joined by the Korean Society of Organic Synthesis.

Supporting Organization: ChemPubSoc Europe

ACES supports the publication of the ChemPubSoc Europe journals Chemistry—A European Journal, the European Journal of Organic Chemistry, and ChemSusChem.

© Wiley-VCH 2012

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Chem Asian J

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Asian J Org Chem

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Angew Chem

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Chem Eur J

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Eur J Org Chem

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ChemSusChem

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Chem Rec

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J Chin Chem Soc

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News

Editorials: New Developments

Chemistry - An Asian Journal Theresa Kueckmann
A Good Year
Chem. Asian J. 2014 9, 4.

Asian Journal of Organic ChemistryRichard Threlfall
There's an App for That
Asian J. Org. Chem. 2014 3, 3.

 

Research of the DayEditors' Choice: Spotlights

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A Metallic Room-Temperature Oxide Ion Conductor

A Metallic Room-Temperature Oxide Ion Conductor

Oxygen topochemistry: Nanoparticles of Bi3Ir, a hitherto uncharacterized intermetallic compound, reversibly intercalate oxygen from air at room temperature. In the resulting metallic suboxide, the intermetallic building units are preserved. The activation energy for oxide diffusion is one order of magnitude smaller than that in any known material. Bi3IrOx is the first metallic oxide ion conductor and also the first that operates at room temperature.

[Communication]
Martin Heise, Bertold Rasche, Anna Isaeva, Alexey I. Baranov, Michael Ruck, Konrad Schäfer, Rainer Pöttgen, Jens-Peter Eufinger, Jürgen Janek
Angew. Chem. Int. Ed. 2014, 53, No. 28, 7344. Read article.

Ultrahigh-Resolution NMR Spectroscopy

Ultrahigh-Resolution NMR Spectroscopy

All psyched up: A flexible and general pure shift experiment (PSYCHE) has been developed that offers superior sensitivity, spectral purity, and tolerance of strong coupling over existing methods for broadband homonuclear decoupling. The partial spectra of estradiol in [D6]DMSO obtained by normal 1H NMR spectroscopy and PSYCHE are shown for comparison.

[Communication]
Mohammadali Foroozandeh, Ralph W. Adams, Nicola J. Meharry, Damien Jeannerat, Mathias Nilsson, Gareth A. Morris
Angew. Chem. Int. Ed. 2014, 53, No. 27, 6990. Read article.

Scorpionate-Type Coordination in MFU-4l Metal–Organic Frameworks: Small-Molecule Binding and Activation upon the Thermally Activated Formation of Open Metal Sites

Scorpionate-Type Coordination in MFU-4l Metal–Organic Frameworks: Small-Molecule Binding and Activation upon the Thermally Activated Formation of Open Metal Sites

On again, off again: Coordinatively unsaturated metal centers, such as zinc(II) hydride and copper(I), were generated within the MFU-4l structure (see picture). CuI-MFU-4l showed reversible chemisorption of O2, N2, and H2 with isosteric heats of adsorption of 32–53 kJ mol−1. The demonstrated hydride transfer to electrophiles and strong binding of small gas molecules indicate the potential of these metal–organic frameworks as catalytic materials.

[Communication]
Dmytro Denysenko, Maciej Grzywa, Jelena Jelic, Karsten Reuter, Dirk Volkmer
Angew. Chem. Int. Ed. 2014, 53, No. 23, 5832. Read article.

Molybdenum Carbide as Alternative Catalysts to Precious Metals for Highly Selective Reduction of CO2 to CO

Molybdenum Carbide as Alternative Catalysts to Precious Metals for Highly Selective Reduction of CO2 to CO

Active, selective, and cheap: Mo2C and cobalt-modified Mo2C were both shown to be effective catalysts for CO2 conversion by hydrogen in flow reactor experiments over powder catalysts. In-situ XANES measurements verified that Mo2C can undergo an oxidation-carburization cycle. Modifying Mo2C with small amounts of cobalt further improved catalytic performance.

[Communication]
Marc D. Porosoff, Xiaofang Yang, J. Anibal Boscoboinik, Jingguang G. Chen
Angew. Chem. Int. Ed. 2014, 53, No. 26, 6705. Read article.

Design of Peptidyl Thiourea Derivatives as Organocatalysts for the Asymmetric Ring Opening of meso-Stilbene Oxides

Design of Peptidyl Thiourea Derivatives as Organocatalysts for the Asymmetric Ring Opening of meso-Stilbene Oxides

Stilbene, not has-been: The design and synthesis of chiral peptidyl thiourea organocatalysts for asymmetric ring opening of cis-stilbene oxides with N-phenylpiperazines is reported. Chiral β-amino alcohols are obtained in up to 95 % ee after crystallization. The configuration at the N-terminal residue of the peptidyl thiourea organocatalyst affects the stereochemical outcome of the reaction.

[Communication]
Swapandeep Singh Chimni, Vikas Kumar, Neeraj Bala
Asian J. Org. Chem. 2014, 3, No. 6, 700. Read article.

Catalytic Allylation of Hypophosphorous Acid and H-Phosphinic Acids with Primary Allylic Amines

Catalytic Allylation of Hypophosphorous Acid and H-Phosphinic Acids with Primary Allylic Amines

Call in the ally-ls: Allylation reactions of hypophosphorous acid and H-phosphinic acids with primary allylic amines in the presence of a palladium catalyst have been developed (see scheme). Importantly, the reactions are highly atom-economic and yield ammonia as the sole byproduct. dba= dibenzylideneacetone.

[Communication]
Xue-Song Wu, Meng-Guang Zhou, Yan Chen, Shi-Kai Tian
Asian J. Org. Chem. 2014, 3, No. 6, 711. Read article.

Water Repellency in Hydrophobic Nanocapsules—Molecular View on Dewetting

Water Repellency in Hydrophobic Nanocapsules—Molecular View on Dewetting

Get away: Water molecules in spherical hydrophobic metal oxide capsules are repelled from the hydrophobic internal ligand walls (“water's response to the fear of water”) and form hydrogen-bonded spherical shells.

[Full Paper]
Achim Müller, Somenath Garai, Christian Schäffer, Alice Merca, Hartmut Bögge, Ahmed Jasim M. Al-Karawi, Thazhe Kootteri Prasad
Chem. Eur. J. 2014, 20, No. 22, 6659. Read article.

Palladium and Gold Nanotubes as Oxygen Reduction Reaction and Alcohol Oxidation Reaction Catalysts in Base

Palladium and Gold Nanotubes as Oxygen Reduction Reaction and Alcohol Oxidation Reaction Catalysts in Base

Pd ORR Au: Palladium nanotubes (PdNTs) and gold nanotubes (AuNTs) are studied as oxygen reduction reaction (ORR) and alcohol oxidation reaction catalysts in base. PdNTs and AuNTs produce ORR area activities that are 2.9 and 2.3 times greater than those produced by Pd/C and Au/C, respectively. The PdNTs further show improved methanol, ethanol, and ethylene glycol oxidation activity in comparison to nanoparticle catalysts.

[Full Paper]
Shaun M. Alia, Kathlynne Duong, Toby Liu, Kurt Jensen, Yushan Yan
ChemSusChem 2014, 7, No. 6, 1739. Read article.

Straightforward Access to Hexahydropyrrolo[2,3-b]indole Core by a Regioselective C3-Azo Coupling Reaction of Arenediazonium Compounds with Tryptamines

Straightforward Access to Hexahydropyrrolo[2,3-b]indole Core by a Regioselective C3-Azo Coupling Reaction of Arenediazonium Compounds with Tryptamines

A new method for construction of the pyrroloindoline framework by way of arenediazonium-triggered cyclization of tryptamines allows for direct and efficient access to a synthetically important structural motif. The reaction is the first example of diazonium-induced 1,2-diamination.

[Full Paper]
David E. Stephens, Oleg V. Larionov
Eur. J. Org. Chem. 2014, No. 17, 3662. Read article.

A Glutathione-Activated Phthalocyanine-Based Photosensitizer for Photodynamic Therapy

A Glutathione-Activated Phthalocyanine-Based Photosensitizer for Photodynamic Therapy

Light therapy: Fluorescence emission and reactive oxygen species generation are greatly enhanced in a molecular phthalocyanine-quencher system upon interaction with glutathione (see figure). Its activation has also been demonstrated in vivo.

[Communication]
Hui He, Pui-Chi Lo, Dennis K. P. Ng
Chem. Eur. J. 2014, 20, No. 21, 6241. Read article.

Discovery of 14-3-3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

Discovery of 14-3-3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

Pièce de résistance! Multidrug resistance (MDR) is the main obstacle toward effective anticancer therapy. Herein we report the discovery of two small-molecule 14-3-3 protein–protein interaction inhibitors that promote the translocation of c-Abl and FOXO pro-apoptotic factors into the nucleus and sensitize MDR cancer cells to doxorubicin and the pan-Akt inhibitor GSK690693.

[Full Paper]
Mattia Mori, Giulia Vignaroli, Ylenia Cau, Jelena Dinić, Richard Hill, Matteo Rossi, David Colecchia, Milica Pešić, Wolfgang Link, Mario Chiariello, Christian Ottmann, Maurizio Botta
ChemMedChem 2014, 9, No. 5, 973. Read article.

Synthesis of Mesoporous TiO2/SiO2 Hybrid Films as an Efficient Photocatalyst by Polymeric Micelle Assembly

Synthesis of Mesoporous TiO2/SiO2 Hybrid Films as an Efficient Photocatalyst by Polymeric Micelle Assembly

Photoactive hybrids: Thermally stable mesoporous TiO2/SiO2 hybrid films with pore size of 50 nm have been synthesized by adopting the polymeric micelle-assembly method. A triblock copolymer, poly(styrene-b-2-vinyl pyridine-b-ethylene oxide), which serves as a template for the mesopores, was utilized to form polymeric micelles (see figure).

[Full Paper]
Yunqi Li, Bishnu Prasad Bastakoti, Masataka Imura, Soo Min Hwang, Ziqi Sun, Jung Ho Kim, Shi Xue Dou, Yusuke Yamauchi
Chem. Eur. J. 2014, 20, No. 20, 6027. Read article.

Generation of (+)-Prezizanol, (+)-Prezizaene, and the ent-β-Isopipitzol Framework via Cationic Rearrangement of Khusiol and Related Compounds

Generation of (+)-Prezizanol, (+)-Prezizaene, and the ent-β-Isopipitzol Framework via Cationic Rearrangement of Khusiol and Related Compounds

Ringing the changes with khusiol: Two distinct rearrangements that take place within the khusiol framework are reported. In the first, the reaction of khusiol or its C8 epimer with POCl3 in pyridine affords (+)-prezizaene, whereas in the second, treatment of a related cyclic sulfate with NaBH4 in N,N-dimethylformamide affords a pleasant smelling alcohol that embodies the ent-β-isopipitzol framework.

[Full Paper]
Mukesh K. Sharma, Martin G. Banwell, Anthony C. Willis
Asian J. Org. Chem. 2014, 3, No. 5, 632. Read article.

A Glimpse into the Molecular Journey inside an Ultralow Sulfur Diesel Reactor

A Glimpse into the Molecular Journey inside an Ultralow Sulfur Diesel Reactor

Keeping on the ultralow: Quantitative information about the journey of sulfur molecules inside an operating ultralow sulfur diesel reactor is provided. This information coupled with other new insights obtained under realistic industrial conditions is expected to significantly increase the effectiveness of future studies aimed at increasing the efficiency of the ultralow sulfur diesel process. ppmw=parts per million by weight

[Full Paper]
Tushar V. Choudhary, Kening Gong, Phillipp Ellison, Ayyappan Subbiah
ChemCatChem 2014, 6, No. 6, 1782. Read article.

Inorganic-Base-Catalysed Synthesis of α,β-Unsaturated Ketones and 3,5-Disubstituted Cyclohex-2-en-1-ones

Inorganic-Base-Catalysed Synthesis of α,β-Unsaturated Ketones and 3,5-Disubstituted Cyclohex-2-en-1-ones

Drop the base: A barium-hydroxide-catalysed domino reaction between aldehydes and acetone that furnishes 3,5-disubstituted cyclohex-2-enone is described. A similar potassium-carbonate-catalysed reaction between aldehydes and acetone that affords α,β-unsaturated methyl ketones, which can be easily transformed into cyclohexenones in the presence of barium hydroxide is also presented.

[Full Paper]
Hongqi Tao, Jindian Duan, Pengfei Li
Asian J. Org. Chem. 2014, 3, No. 5, 644. Read article.

Solution-NMR Characterization of Outer-Membrane Protein A from E. coli in Lipid Bilayer Nanodiscs and Detergent Micelles

Solution-NMR Characterization of Outer-Membrane Protein A from E. coli in Lipid Bilayer Nanodiscs and Detergent Micelles

NMR studies of OmpA in nanodiscs yielded structural data on this E coli outer membrane protein closely similar to those seen in three different detergent micelles. The result validates the use of detergent micelles for structural studies of β-barrel membrane proteins and supports the conjecture that the conformational dynamics of OmpA observed for the reconstituted protein are related to its physiological function.

[Full Paper]
Lukas Sušac, Reto Horst, Kurt Wüthrich
ChemBioChem 2014, 15, No. 7, 995. Read article.

Catalytic Molecular Logic Devices by DNAzyme Displacement

Catalytic Molecular Logic Devices by DNAzyme Displacement

Catalytic control: We demonstrate a simple, programmable method for controlling the catalytic activity of DNAzymes using DNA strand displacement reactions. This work broadens the impact of strand displacement logic devices by using the rich range of biochemical reactions catalyzed by DNAzymes as outputs.

[Communication]
Carl W. Brown, IIIMatthew R. Lakin, Darko Stefanovic, Steven W. Graves
ChemBioChem 2014, 15, No. 7, 950. Read article.

O-Trifluoromethylation of N,N-Disubstituted Hydroxylamines with Hypervalent Iodine Reagents

O-Trifluoromethylation of N,N-Disubstituted Hydroxylamines with Hypervalent Iodine Reagents

Electrophilic trifluoromethylation of dialkyl hydroxylamines with hypervalent iodine(III) reagents gives access to compounds containing the virtually unexplored NOCF3 functional group. Aspects concerning synthesis, properties, and reaction mechanism are presented. The transformation is also applicable to hydroxylamines derived from common drugs and shows a broad functional group tolerance.

[Short Communication]
Václav Matoušek, Ewa Pietrasiak, Lukas Sigrist, Barbara Czarniecki, Antonio Togni
Eur. J. Org. Chem. 2014, No. 15, 3087. Read article.

Magnetic Coupling and Optical Properties of the S6-Dodecakis(trifluoromethyl)fullerene Radical Anions in the Layered Salt (PPN+)[C60(CF3)12.−]

Magnetic Coupling and Optical Properties of the S6-Dodecakis(trifluoromethyl)fullerene Radical Anions in the Layered Salt (PPN+)[C60(CF3)12.−]

Anionic fullerenes: A salt of a multiply derivatized fullerene anion, namely, (PPN+)[C60(CF3)12.−] (1; PPN+=bis(triphenylphosphine)iminium), was obtained as single crystals (see figure; C gray, F green). The crystals of 1 exhibit a narrow EPR signal and rather strong antiferromagnetic coupling between the spins of the C60(CF3)12.− radical anions. It was assumed that this coupling is mediated by the network of short F···F contacts in the layers of radical anions.

[Full Paper]
Dmitri V. Konarev, Natalia A. Romanova, Roman A. Panin, Alexey A. Goryunkov, Sergey I. Troyanov, Rimma N. Lyubovskaya
Chem. Eur. J. 2014, 20, No. 18, 5380. Read article.

Stereoselective Synthesis of Proline-Derived Dipeptide Scaffolds (ProM-3 and ProM-7) Rigidified in a PPII Helix Conformation

Stereoselective Synthesis of Proline-Derived Dipeptide Scaffolds (ProM-3 and ProM-7) Rigidified in a PPII Helix Conformation

Starting from amino acid building blocks with an olefin side chain, the diastereomeric scaffolds ProM-3 and ProM-7 are synthesized through peptide coupling and ring-closing metathesis. The conformationally defined dipeptide analogs are of interest as building blocks for the synthesis of modular PPII helix secondary structure mimetics as tailored inhibitors of protein–protein interactions.

[Short Communication]
Cédric Reuter, Margarethe Kleczka, Sarah de Mazancourt, Jörg-Martin Neudörfl, Ronald Kühne, Hans-Günther Schmalz
Eur. J. Org. Chem. 2014, No. 13, 2664. Read article.

Supramolecular Proteoglycan Aggregate Mimics: Cyclodextrin-Assisted Biodegradable Polymer Assemblies for Electrostatic-Driven Drug Delivery

Supramolecular Proteoglycan Aggregate Mimics: Cyclodextrin-Assisted Biodegradable Polymer Assemblies for Electrostatic-Driven Drug Delivery

Drug deal: Self-assembled, noncovalent polymeric biodegradable materials mimicking proteoglycan aggregates in their structure are synthesized and loaded with both hydrophilic and lipophilic model drugs as well as with bovine serum albumin. The release of the entrapped drugs from the supramolecular matrices is controlled by electrostatic interactions with the cations in the surrounding media and by biodegradation.

[Full Paper]
Lajos Szente, István Puskás, Katalin Csabai, Eva Fenyvesi
Chem. Asian J. 2014, 9, No. 5, 1365. Read article.

Facile Identification of Dual FLT3–Aurora A Inhibitors: A Computer-Guided Drug Design Approach

Facile Identification of Dual FLT3–Aurora A Inhibitors: A Computer-Guided Drug Design Approach

In silico selection: We selected an Aurora hit compound as a starting point, followed by two consecutive computer-guided strategies to rapidly and efficiently modify the side chain and core. These efforts resulted in the identification of a potential FLT3–Aurora A inhibitor for further development to treat acute myeloid leukemia (AML).

[Full Paper]
Yung Chang Hsu, Yi-Yu Ke, Hui-Yi Shiao, Chieh-Chien Lee, Wen-Hsing Lin, Chun-Hwa Chen, Kuei-Jung Yen, John T.-A. Hsu, Chungming Chang, Hsing-Pang Hsieh
ChemMedChem 2014, 9, No. 5, 953. Read article.

A Coumarin-Labeled Vinyl Sulfone as Tripeptidomimetic Activity-Based Probe for Cysteine Cathepsins

A Coumarin-Labeled Vinyl Sulfone as Tripeptidomimetic Activity-Based Probe for Cysteine Cathepsins

Tricycle light: A tripeptidomimetic, vinyl sulfone-type activity-based probe containing a rigid coumarin moiety fluorophore was prepared by convergent synthesis. The probe was evaluated as an inactivator of human cathepsins and, as exemplified with cathepsin S, it proved to be suitable for imaging in SDS-PAGE.

[Communication]
Matthias D. Mertens, Janina Schmitz, Martin Horn, Norbert Furtmann, Jürgen Bajorath, Michael Mareš, Michael Gütschow
ChemBioChem 2014, 15, No. 7, 955. Read article.

Synthesis and Electrocatalytic Properties of H2SO4-Induced (100) Pt Nanoparticles Prepared in Water-in-Oil Microemulsion

Synthesis and Electrocatalytic Properties of H2SO4-Induced (100) Pt Nanoparticles Prepared in Water-in-Oil Microemulsion

Shapewear for nanoparticles: Sulfuric acid is used as a surface modifier to synthesize (100) Pt nanoparticles (NPs) by using a water-in-oil microemulsion method. The electrocatalytic properties of the resulting cubic-like Pt NPs are evaluated towards ammonia and CO electro-oxidations.

[Communication]
Roberto A. Martínez-Rodríguez, Francisco J. Vidal-Iglesias, José Solla-Gullón, Carlos R. Cabrera, Juan M. Feliu
ChemPhysChem 2014, 15, No. 10, 1997. Read article.

Nanosecond Dynamics of Calmodulin and Ribosome-Bound Nascent Chains Studied by Time-Resolved Fluorescence Anisotropy

Nanosecond Dynamics of Calmodulin and Ribosome-Bound Nascent Chains Studied by Time-Resolved Fluorescence Anisotropy

All wrapped up: Coupling between polypeptide chain elongation and protein folding is a key issue in protein biosynthesis. We present an experimental approach to analyze the structural and dynamic properties of nascent polypeptide chains synthesized by a cell-free expression system with truncated peptides. For calmodulin we identified a pronounced interaction of the nascent chains with the synthesizing ribosome.

[Full Paper]
Paraskevas Lamprou, Daryan Kempe, Alexandros Katranidis, Georg Büldt, Jörg Fitter
ChemBioChem 2014, 15, No. 7, 977. Read article.

Characterization of a Fluidized Catalytic Cracking Catalyst on Ensemble and Individual Particle Level by X-ray Micro- and Nanotomography, Micro-X-ray Fluorescence, and Micro-X-ray Diffraction

Characterization of a Fluidized Catalytic Cracking Catalyst on Ensemble and Individual Particle Level by X-ray Micro- and Nanotomography, Micro-X-ray Fluorescence, and Micro-X-ray Diffraction

Mini techniques, bigger picture: A combination of advanced characterization techniques, synchrotron X-ray micro- and nanotomography, micro-X-ray fluorescence, and micro-XRD, are used to characterize a commercial spent equilibrium fluid catalytic cracking catalyst at both the ensemble and individual particle level.

[Full Paper]
Simon R. Bare, Meghan E. Charochak, Shelly D. Kelly, Barry Lai, Jun Wang, Yu-chen Karen Chen-Wiegart
ChemCatChem 2014, 6, No. 5, 1427. Read article.

Insights into the Organocatalyzed Synthesis of Urethanes in Supercritical Carbon Dioxide: An In Situ FTIR Spectroscopic Kinetic Study

Insights into the Organocatalyzed Synthesis of Urethanes in Supercritical Carbon Dioxide: An In Situ FTIR Spectroscopic Kinetic Study

Back to the FTIR: The most efficient organocatalysts have been identified for the reaction of alcohols with isocyanates in supercritical CO2 in a step towards a green process for polyurethane synthesis. The order of activity of the catalysts in supercritical CO2 does not always follow that observed in conventional media.

[Full Paper]
Christopher A. Smith, Henri Cramail, Thierry Tassaing
ChemCatChem 2014, 6, No. 5, 1380. Read article.

3-Phenylpropanoic Acid-Based Phosphotyrosine (pTyr) Mimetics: Hit Evolution to a Novel Orally Active Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitor

3-Phenylpropanoic Acid-Based Phosphotyrosine (pTyr) Mimetics: Hit Evolution to a Novel Orally Active Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitor

A sincere form of flattery: A novel protein tyrosine phosphatase 1B (PTP1B) inhibitor with a 3-phenylpropanoic acid moiety as a phosphotyrosine (pTyr) mimetic was optimized to provide an orally active lead compound with an IC50 value of 0.40 μM against PTP1B and more notably that displayed significant in vivo activity in a murine insulin resistance model.

[Communication]
Yan-Bo Tang, Jun-Zheng Liu, Shu-En Zhang, Xin Du, Feilin Nie, Jin-Ying Tian, Fei Ye, Kai Huang, Jin-Ping Hu, Yan Li, Zhiyan Xiao
ChemMedChem 2014, 9, No. 5, 918. Read article.

Designing Fractal Nanostructured Biointerfaces for Biomedical Applications

Designing Fractal Nanostructured Biointerfaces for Biomedical Applications

Facing forward: Fractal structures offer a unique “fractal contact mode” that guarantees the efficient working of organisms with an optimized style. Fractal nanostructured biointerfaces show great potential for the ultrasensitive detection of various disease-relevant biomarkers, such as microRNA, cancer antigen 125, and breast cancer cells, from unpurified cell lysates and the blood of patients.

[Minireview]
Pengchao Zhang, Shutao Wang
ChemPhysChem 2014, 15, No. 8, 1550. Read article.

Effects of Adsorbate Coverage and Bond-Length Disorder on the d-Band Center of Carbon-Supported Pt Catalysts

Effects of Adsorbate Coverage and Bond-Length Disorder on the d-Band Center of Carbon-Supported Pt Catalysts

Don't let disorder bother you: Using resonant inelastic X-ray scattering (RIXS) measurements the changes in the d-band center of carbon-supported Pt nanocatalysts are imaged in response to variable temperatures and gas atmospheres. Theoretical analysis of RIXS data reveals that the d-band-center shift toward the Fermi level at elevated temperatures is dominated by the decrease in adsorbate coverage, whereas the increase of bond-length disorder plays no significant role.

[Communication]
Matthew W. Small, Joshua J. Kas, Kristina O. Kvashnina, John J. Rehr, Ralph G. Nuzzo, Moniek Tromp, Anatoly I. Frenkel
ChemPhysChem 2014, 15, No. 8, 1569. Read article.

Facile Synthesis of Carbon-Encapsulated Li4Ti5O12@C Hollow Microspheres as Superior Anode Materials for Li-Ion Batteries

Facile Synthesis of Carbon-Encapsulated Li4Ti5O12@C Hollow Microspheres as Superior Anode Materials for Li-Ion Batteries

A solution-phase self-assembly and solid-phase carbonization route for the synthesis of uniform hollow carbon microspheres embedded with Li4Ti5O12 nanoparticles has been developed. The microsized spherical Li4Ti5O12@C hollow composites have conductive carbon shells, which endow them with high specific capacity, rate capability, electrode density, and cycle stability.

[Full Paper]
Jun Liu, Wei Liu, Shaomin Ji, Yanling Wan, Huaqi Yin, Yichun Zhou
Eur. J. Inorg. Chem. 2014, No. 12, 2073. Read article.

Kinetic Evidence of Tautomerism of Thiourea Dioxide in Aqueous Acidic Solutions

Kinetic Evidence of Tautomerism of Thiourea Dioxide in Aqueous Acidic Solutions

Kinetic evidence of the tautomerism of thiourea dioxide in aqueous acidic solutions is reported. The reactivity of the two tautomeric forms towards ClO2 significantly differs in rate and also in mechanistic aspects. Whereas aminoiminomethanesulfinic acid reacts with ClO2 in a second-order process, the reaction of its tautomeric form, thiourea dioxide, with ClO2 displays autocatalysis.

[Short Communication]
György Csekő, Ying Hu, Yanan Song, Tímea R. Kégl, Qingyu Gao, Sergei V. Makarov, Attila K. Horváth
Eur. J. Inorg. Chem. 2014, No. 11, 1875. Read article.

Role of the Base and Control of Selectivity in the Suzuki–Miyaura Cross-Coupling Reaction

Role of the Base and Control of Selectivity in the Suzuki–Miyaura Cross-Coupling Reaction

Follow the organoborate road: Competition Suzuki–Miyaura reactions between two boronic acids with different pKa values reveal the link between acid–base chemistry and the reaction catalytic cycle. The results reveal that the borate path is the preferred route for transmetalation and thus confirm the role of the base in the reaction mechanism.

[Full Paper]
Carlos F. R. A. C. Lima, Ana S. M. C. Rodrigues, Vera L. M. Silva, Artur M. S. Silva, Luís M. N. B. F. Santos
ChemCatChem 2014, 6, No. 5, 1291. Read article.

Multi-Pyrene Assemblies Supported on Stannoxane Frameworks: Synthesis, Structure and Photophysical Studies

Multi-Pyrene Assemblies Supported on Stannoxane Frameworks: Synthesis, Structure and Photophysical Studies

Ring-tin-tin: The reactions of pyrene sulfonic acid (PySO3H) or C16H9CHNC6H3(COOH)2 (LH2) with various organotin precursors afforded pyrene-containing organostannoxanes (see figure), such as [Ph3SnPySO3]6 (1), [{(Me2Sn)23-O)(μ-OH)PySO3}2{(Me2Sn)23-O)(μ-OH)H2O}2·2 PySO3] (2), [{tBu2Sn(OH)PySO3}2] (3), [{(nBuSn)12(O)14(OH)6{PySO3}2] (4), and [{(nBu2Sn)L}3]2·C6H5CH3 (5) which show interesting photophysical properties.

[Full Paper]
Subrata Kundu, Ramesh K. Metre, Rajeev Yadav, Pratik Sen, Vadapalli Chandrasekhar
Chem. Asian J. 2014, 9, No. 5, 1403. Read article.

Oxygen-Terminated Diamond Electrodes in Alkaline Media: Structure and OH Generation

Oxygen-Terminated Diamond Electrodes in Alkaline Media: Structure and OH Generation

Not only a girl's best friend: Boron-doped diamond is important as an electrode material. Oxygen-terminated diamonds and the kinetics of OH generation in alkaline solutions on this type of surface are studied theoretically; this allows detailed structure and energetics characterization of the systems, as well as an understanding of the reaction dynamics that proceed in an outer-sphere mode.

[Article]
Paola M. Quaino, Wolfgang Schmickler
ChemElectroChem 2014, 1, No. 5, 933. Read article.

Electrochemical Desalination for a Sustainable Water Future

Electrochemical Desalination for a Sustainable Water Future

From seawater to a table near you: Electrochemically mediated desalination is presented within the context of existing thermal, membrane, and electrochemical desalination techniques, while explaining many of the underlying concepts guiding the development of desalination technologies.

[Concept]
Kyle N. Knust, Dzmitry Hlushkou, Ulrich Tallarek, Richard M. Crooks
ChemElectroChem 2014, 1, No. 5, 850. Read article.

Nonlinear Self-Organizing Kinetics in the Electrochemical Growth of Alumina Nanotube Arrays

Nonlinear Self-Organizing Kinetics in the Electrochemical Growth of Alumina Nanotube Arrays

Organizational hazard: Self-organizing kinetics during the electrosynthesis of porous anodic alumina is investigated. The ordered nanoarray forms through the self-organizing condensed cations in the hydroxide colloid, rather than the traditional pitting-corrosion mechanism. The periodicity of both the nanoarray and the current oscillation are dominated by a nonlinear reaction path, and the dynamic Equations of which are established and analyzed.

[Article]
Xing Fan, Longfa Liao, Yu Chang, Zuohua Liu, Jun Du, Changyuan Tao
ChemElectroChem 2014, 1, No. 5, 925. Read article.

The DiPPro Approach: Synthesis, Hydrolysis, and Antiviral Activity of Lipophilic d4T Diphosphate Prodrugs

The DiPPro Approach: Synthesis, Hydrolysis, and Antiviral Activity of Lipophilic d4T Diphosphate Prodrugs

NDPs delivered! A structure–activity relationship of bioreversibly protected DiPPro–d4TDP was performed. The stability of the compounds was studied in various media such as cell extracts. Stability increased with increasing lipophilicity of the acyl chain. D4TDP was released as main product. Compounds with long acyl residues showed good anti-HIV activities in TK-deficient cells, proving intracellular uptake of the compounds.

[Full Paper]
Tilmann Schulz, Jan Balzarini, Chris Meier
ChemMedChem 2014, 9, No. 4, 762. Read article.

Switchable Ionic Liquids as Delignification Solvents for Lignocellulosic Materials

Switchable Ionic Liquids as Delignification Solvents for Lignocellulosic Materials

Making the switch: A feasible fractionation method of birch chips (B. pendula) is developed by using a switchable ionic liquid (SIL) derived from an alkanol amine (monoethanol amine, MEA) and an organic super base (1,8-diazabicyclo-[5.4.0]-undec-7-ene, DBU) with two different trigger acid gases (CO2 and SO2) is studied. After SIL treatment, the dissolved fractions are selectively separated by a step-wise method using an antisolvent to induce precipitation. The SIL was recycled after concentration and evaporation of anti-solvent.

[Full Paper]
Ikenna Anugwom, Valerie Eta, Pasi Virtanen, Päivi Mäki-Arvela, Mattias Hedenström, Michael Hummel, Herbert Sixta, Jyri-Pekka Mikkola
ChemSusChem 2014, 7, No. 4, 1170. Read article.

Biopolymer-Supported Ionic-Liquid-Phase Ruthenium Catalysts for Olefin Metathesis

Biopolymer-Supported Ionic-Liquid-Phase Ruthenium Catalysts for Olefin Metathesis

Powerful, reusable, and recyclable catalytic materials based on supported ionic liquid phase (SILP) technology for ruthenium ring-closing metathesis (RCM) and cross metathesis (CM) reactions are reported. The materials use alginate, a cheap, renewable and easily conditioned biopolymer, as support. Their excellent recyclability (15 cycles) combined with their high reactivity in either monophasic or biphasic conditions (use of cyclohexane) makes them excellent choices for RCM and CM reactions.

[Communication]
Nathalie Clousier, Alexandra Filippi, Etienne Borré, Eric Guibal, Christophe Crévisy, Fréderic Caijo, Marc Mauduit, Isabelle Dez, Annie-Claude Gaumont
ChemSusChem 2014, 7, No. 4, 1040. Read article.

Renewable and Functional Wood Materials by Grafting Polymerization Within Cell Walls

Renewable and Functional Wood Materials by Grafting Polymerization Within Cell Walls

Towards smart wood-based materials: The natural wood structure is used as a support to graft vinyl and acrylate monomers. The hydroxyls groups from wood are functionalized with azo-based initiators, which can further initiate polymerization in/from the cell wall structure. The versatile technique yields wood-based materials with new functionalities, and opens the way to new utilizations for bulk wood.

[Communication]
Etienne Cabane, Tobias Keplinger, Vivian Merk, Philipp Hass, Ingo Burgert
ChemSusChem 2014, 7, No. 4, 1020. Read article.

Logic Functions with Stimuli-Responsive Single Nanopores

Logic Functions with Stimuli-Responsive Single Nanopores

Porefection: Electrochemical transducers based on single stimuli-responsive polymeric nanopores can support a complete set of logic functions. Thermal, chemical, electrical, and optical stimuli are the input signals required to externally tune the pore conductance (i.e. the logical output).

[Concept]
Patricio Ramirez, Javier Cervera, Mubarak Ali, Wolfgang Ensinger, Salvador Mafe
ChemElectroChem 2014, 1, No. 4, 698. Read article.

Fluorescence Enhancement of a Porphyrin–Viologen Dyad by Pseudorotaxane Formation with Cucurbit[7]uril

Fluorescence Enhancement of a Porphyrin–Viologen Dyad by Pseudorotaxane Formation with Cucurbit[7]uril

The electron-transfer processes within a donor–acceptor dyad can be readily controlled through the formation of a pseudorotaxane between a viologen acceptor and cucurbit[7]uril.

[Short Communication]
Maher Fathalla, Nathan L. Strutt, Jonathan C. Barnes, Charlotte L. Stern, Chenfeng Ke, J. Fraser Stoddart
Eur. J. Org. Chem. 2014, No. 14, 2873. Read article.

Supramolecular Complexes of Multivalent Cholesterol-Containing Polymers to Solubilize Carbon Nanotubes in Apolar Organic Solvents

Supramolecular Complexes of Multivalent Cholesterol-Containing Polymers to Solubilize Carbon Nanotubes in Apolar Organic Solvents

WitchcRAFT and wizardry: Copolymers of 2-ethylhexyl acrylate and cholesteryloxycarbonyl-2-hydroxymethacrylate (CEM), which contained pendant cholesterol units, formed strong supramolecular complexes with carbon nanotubes, thus preventing their aggregation and stabilizing concentrated colloidal solutions of MWNTs and SWNTs in isooctane, THF, and toluene.

[Full Paper]
Jules Zeuna Nguendia, Weiheng Zhong, Alexandre Fleury, Guillaume De Grandpré, Armand Soldera, Ribal Georges Sabat, Jerome P. Claverie
Chem. Asian J. 2014, 9, No. 5, 1356. Read article.

Tuning Reductive and Oxidative Photoinduced Electron Transfer in Amide-Linked Anthraquinone–Porphyrin–Ferrocene Architectures

Tuning Reductive and Oxidative Photoinduced Electron Transfer in Amide-Linked Anthraquinone–Porphyrin–Ferrocene Architectures

The initial photoinduced electron transfer (PET) in anthraquinone-(porphyrinAr)n-ferrocenes (n = 1, 2) is modulated by the HOMO and LUMO levels of the porphyrin chromophores by meso substituent effects. Electrochemical and spectroscopic data as well as DFT calculations were used to elaborate the preferred PET pathway in these architectures with different electron donation on the porphyrin.

[Full Paper]
Jascha Melomedov, Julian Robert Ochsmann, Michael Meister, Frédéric Laquai, Katja Heinze
Eur. J. Inorg. Chem. 2014, No. 11, 1984. Read article.

Upconversion-Luminescent Core/Mesoporous-Silica-Shell-Structured β-NaYF4:Yb3+,Er3+@SiO2@mSiO2 Composite Nanospheres: Fabrication and Drug-Storage/Release Properties

Upconversion-Luminescent Core/Mesoporous-Silica-Shell-Structured β-NaYF4:Yb3+,Er3+@SiO2@mSiO2 Composite Nanospheres: Fabrication and Drug-Storage/Release Properties

Biocompatibility in vitro, upconversion luminescence imaging, and capability of loading drug of multifunctional β-NaYF4:Yb3+,Er3+@SiO2@mSiO2 nanospheres were investigated.

[Full Paper]
Bei Liu, Chunxia Li, Dongmei Yang, Zhiyao Hou, Ping'an Ma, Ziyong Cheng, Hongzhou Lian, Shanshan Huang, Jun Lin
Eur. J. Inorg. Chem. 2014, No. 11, 1906. Read article.

Remote Impacts of Methyl Substituents on the Guest-Binding Ability of Self-Assembled Cages

Remote Impacts of Methyl Substituents on the Guest-Binding Ability of Self-Assembled Cages

A butterfly effect: The guest-binding ability of a self-assembled cage was remotely and subtly tuned by the pendant substituent groups (see figure) on the metal corners of the cage. Bulky aromatic substituents push the cage framework inward to shrink the cage cavity. A single methyl group difference at the remote site makes a significant difference in guest species and motions within the cages.

[Full Paper]
Yu Fang, Takashi Murase, Makoto Fujita
Chem. Asian J. 2014, 9, No. 5, 1321. Read article.

Hierarchical Hybrid Peroxidase Catalysts for Remediation of Phenol Wastewater

Hierarchical Hybrid Peroxidase Catalysts for Remediation of Phenol Wastewater

Supporting the clean-up: Horseradish peroxidase (HRP)–magnetic nanoparticles are demonstrated as hierarchical hybrid catalysts for the removal of phenol from water. The catalysts exhibit a three times higher activity than free HRP and in comparison are able to remove three times more phenol. Reusability is improved when the hybrids are supported on micron-scale magnetic particles, and can be retained with a specially designed magnetically driven reactor.

[Article]
Xiaonan Duan, Stéphane C. Corgié, Daniel J. Aneshansley, Peng Wang, Larry P. Walker, Emmanuel P. Giannelis
ChemPhysChem 2014, 15, No. 5, 974. Read article.

Cross-Linked Imidazolium Salts as Scavengers for Palladium

Cross-Linked Imidazolium Salts as Scavengers for Palladium

Going on a scavenger hunt: Efficient removal of residual palladium from active pharmaceutical ingredients (APIs) and API intermediates is becoming an increasing problem and new efficient scavengers are being sought. Cross-linked imidazolium bromide salt based materials are easily obtained and show good performances as palladium scavengers (see picture).

[Full Paper]
Roberto Buscemi, Francesco Giacalone, Santino Orecchio, Michelangelo Gruttadauria
ChemPlusChem 2014, 79, No. 3, 421. Read article.

1D and 2D Thiazole-Based Copper(II) Coordination Polymers: Synthesis and Applications in Carbon Dioxide Capture

1D and 2D Thiazole-Based Copper(II) Coordination Polymers: Synthesis and Applications in Carbon Dioxide Capture

Attraction at first sight: Copper(II) thiazole-based coordination polymers have been prepared and characterized; their network dimensionality can be tuned from 1D to 2D through the introduction of specific functional groups on the organic spacers. In one case, a 3D supramolecular scaffold was obtained; the related permanent porosity led to efficient CO2 physical storage at ambient temperature and pressure, which made the material suitable for CO2 capture in post-combustion flue gas (see figure).

[Full Paper]
Andrea Rossin, Giulia Tuci, Giuliano Giambastiani, Maurizio Peruzzini
ChemPlusChem 2014, 79, No. 3, 406. Read article.

Synthesis of Carbon Materials–TiO2 Hybrid Nanostructures and Their Visible-Light Photo-catalytic Activity

Synthesis of Carbon Materials–TiO2 Hybrid Nanostructures and Their Visible-Light Photo-catalytic Activity

Closing the gap: The incorporation of carbon materials onto TiO2 leads to a superior adsorption ability for dye, narrower band gaps, and accelerated separation of electron–hole pairs; these factors enhance the photocatalytic activity of the composites (see picture; RhB=rhodamine B, CB=conduction band, VB=valence band).

[Full Paper]
Qian Li, Juncao Bian, Li Zhang, Ruiqin Zhang, Guozhong Wang, Dickon H. L. Ng
ChemPlusChem 2014, 79, No. 3, 454. Read article.

Palladium-Based Anion-Exchange Membrane Fuel Cell Using KOH-Doped Polybenzimidazole as the Electrolyte

Palladium-Based Anion-Exchange Membrane Fuel Cell Using KOH-Doped Polybenzimidazole as the Electrolyte

The power of three: An anion-exchange membrane fuel cell showing maximum power density as high as 241 mW cm−2 has been developed using a palladium-based electrocatalyst loaded onto the surfaces of carbon nanotubes (see figure). Polybenzimidazole-wrapped carbon nanotubes were used to anchor the Pd nanoparticles, and the material was doped using KOH to form an ideal triple-phase boundary structure around palladium.

[Full Paper]
Tsuyohiko Fujigaya, ChaeRin Kim, Kazuya Matsumoto, Naotoshi Nakashima
ChemPlusChem 2014, 79, No. 3, 400. Read article.

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Non-hinge binding: A novel organometallic protein kinase inhibitor scaffold based on a cyclometalated 1,8-phenanthrolin-7(8 H)-one ligand is reported, which binds to the ATP binding site of the protein kinase Pim1 in an unexpected, unusual non-ATP-mimetic fashion without mimicking the hydrogen-bonding interaction of the adenine nucleobase of ATP.

[Communication]
Kathrin Wähler, Katja Kräling, Holger Steuber, Eric Meggers
ChemistryOpen 2013, 2, No. 5-6, 180. Read article.

Solid-State-Trapped Reactive Ammonium Carbamate Self-Derivative Salts of Prolinamide

Solid-State-Trapped Reactive Ammonium Carbamate Self-Derivative Salts of Prolinamide

Trapped within: We report single-crystal characterization of polymorphs of the ammonium carbamate self-derivative salt of prolinamide, and the first crystal structure of prolinamide and of derived products. This study emphasizes the reactivity of carbonated amines in the solid state and opens perspectives for a systematic study of (solid-state) reactions involving these trapped reactive species.

[Full Paper]
Anaëlle Tilborg, Steve Lanners, Bernadette Norberg, Johan Wouters
ChemistryOpen 2013, 2, No. 5-6, 194. Read article.

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI-MS

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI-MS

Simple and effective: A facile procedure for monitoring chemical reactions and characterizing compounds dissolved in ionic liquids is described using the MS/MS technique. Separation of species of interest was carried out using internal electronic gate available in electrospray mass spectrometers, instead of chromatography and extraction. The separation was carried out as a fast (milliseconds) and sustainable (no extra solvents) procedure.

[Full Paper]
Levon L. Khemchyan, Elena A. Khokhlova, Marina M. Seitkalieva, Valentine P. Ananikov
ChemistryOpen 2013, 2, No. 5-6, 208. Read article.

Metastable β-Bi2O3 Nanoparticles with Potential for Photocatalytic Water Purification Using Visible Light Irradiation

Metastable β-Bi2O3 Nanoparticles with Potential for Photocatalytic Water Purification Using Visible Light Irradiation

Water purification with β-Bi2O3: A straightforward synthetic procedure for the synthesis of β-Bi2O3 nanoparticles that offers the potential for gram-scale production is presented. The β-Bi2O3 nanoparticles show high photocatalytic activity and stability in the degradation of typical organic water pollutants under visible light irradiation. These nanoparticles might be promising materials for use in novel water purification systems.

[Full Paper]
Maik Schlesinger, Marcus Weber, Steffen Schulze, Michael Hietschold, Michael Mehring
ChemistryOpen 2013, 2, No. 4, 146. Read article.