Mission Statement

The Asian Chemical Editorial Society (ACES) is an organization of 13 major chemical societies in Asia and the Pacific. It was founded in 2005 as a conglomeration of chemical societies with the mutual aim of creating a modern publishing forum for research in Asia and coordinating future publishing activities.

The participating societies share a commitment to scientific excellence, to publishing ethics, and to the highest standards in publication, which are the basis for the success of Chemistry—An Asian Journal and its associated journals.

Publications

Chemistry—An Asian Journal

A sister journal of Angewandte Chemie and Chemistry—A European Journal

Supporting Organizations: ChemPubSoc Europe, Gesellschaft Deutscher Chemiker (German Chemical Society, GDCh), Federation of Asian Chemical Societies (FACS).

Asian Journal of Organic Chemistry

A sister journal of the European Journal of Organic Chemistry

For the publication of the AsianJOC, ACES is joined by the Korean Society of Organic Synthesis.

Supporting Organization: ChemPubSoc Europe

ACES supports the publication of the ChemPubSoc Europe journals Chemistry—A European Journal, the European Journal of Organic Chemistry, and ChemSusChem.

© Wiley-VCH 2012

Journals

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Chem Asian J

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Asian J Org Chem

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ChemNanoMat

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Angew Chem

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Chem Eur J

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Eur J Org Chem

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ChemSusChem

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Chem Rec

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News

Editorials: New Developments

Chemistry - An Asian Journal Theresa Kueckmann
A Reason to Celebrate!
Chem. Asian J. 2015 10, 4.

Asian Journal of Organic ChemistryRichard Threlfall
Something Old, Something New, Something Borrowed, Something Blue
Asian J. Org. Chem. 2015 4, 4.

Asian Journal of Organic ChemistryTheresa Kueckmann, Claire Cobley
ChemNanoMat—A New Journal for Small Science with a Big Impact
ChemNanoMat 2015, 1, 4–8.

 

Research of the DayEditors' Choice: Spotlights

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50 Years in the Sun of Bürgenstock—On the Success Factors of a Famous Conference

50 Years in the Sun of Bürgenstock—On the Success Factors of a Famous Conference

The secret of success: This year the famous “Bürgenstock Conference” will take place for the 50th time. This conference has become internationally one of the, if not the, most highly regarded conference in chemistry, chemical biology, and physical chemistry. What are the success factors of this conference? These as well as a number of perhaps more hidden figures and facts are discussed.

[Essay]
Klaus Müller
Angew. Chem. Int. Ed. 2015, 54, No. 17, 5012. Read article.

Oxidation State, A Long-Standing Issue!

Oxidation State, A Long-Standing Issue!

What is an oxidation state? Oxidation state has defining algorithms but lacks a comprehensive definition. Results of an IUPAC project to find such a definition have recently been published in an extensive Technical Report. A summary in this Essay is illustrated with applications on Lewis, bond-graph, and summary formulas of molecules, ions, or solids, together with the most recent information regarding tricky cases.

[Essay]
Pavel Karen
Angew. Chem. Int. Ed. 2015, 54, No. 16, 4716. Read article.

Enantioselective Catalysis of Photochemical Reactions

Enantioselective Catalysis of Photochemical Reactions

All good things come in threes: With catalysis, light, and chirality, three of the most important scientific phenomena merge in the field of the enantioselective catalysis of photochemical reactions. This Review introduces the main concepts and provides an overview of the key findings in this area.

[Review]
Richard Brimioulle, Dominik Lenhart, Mark M. Maturi, Thorsten Bach
Angew. Chem. Int. Ed. 2015, 54, No. 13, 3872. Read article.

Incorporation of Calix[6]Arene Macrocycles and (Pseudo)Rotaxanes in Bilayer Membranes: Towards Controllable Artificial Liposomal Channels

Incorporation of Calix[6]Arene Macrocycles and (Pseudo)Rotaxanes in Bilayer Membranes: Towards Controllable Artificial Liposomal Channels

Hitchin' a chlo-ride: The role of calix[6]arene-based pseudorotaxanes and rotaxanes on transmembrane transport of ions such as chloride and 5(6)-carboxyfluorescein across the bilayer of liposomes composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (diameter 100 nm) was investigated. The findings may pave the way for the construction of new generations of pharmacological systems regulating the transport of chloride ions.

[Full Paper]
Romina Zappacosta, Antonella Fontana, Alberto Credi, Arturo Arduini, Andrea Secchi
Asian J. Org. Chem. 2015, 4, No. 3, 262. Read article.

Catalytic Upgrading of Biomass-Derived Methyl Ketones to Liquid Transportation Fuel Precursors by an Organocatalytic Approach

Catalytic Upgrading of Biomass-Derived Methyl Ketones to Liquid Transportation Fuel Precursors by an Organocatalytic Approach

Dimerize it: A highly efficient, water-tolerant, solid-base organocatalyst for selective dimerization of biomass-derived methyl ketones was developed by tethering amines on a Brønsted acidic silica–alumina support. C4–C15 methyl ketones can be catalytically upgraded to the dimer products with high selectivity. DFT analysis and experimental data suggest that C-C bond formation is the rate-determining step.

[Communication]
Shylesh Sankaranarayanapillai, Sanil Sreekumar, Joseph Gomes, Adam Grippo, George E. Arab, Martin Head-Gordon, F. Dean Toste, Alexis T. Bell
Angew. Chem. Int. Ed. 2015, 54, No. 15, 4673. Read article.

Synthesis, Photophysics, and Electronic Structures of Benzene-Linked Bispyrimidine Compounds

Synthesis, Photophysics, and Electronic Structures of Benzene-Linked Bispyrimidine Compounds

Two or tree? Seven multidipole and multibranched benzene-linked bispyrimidine derivatives containing a two-layer binary tree structure have been designed, synthesized, and characterized. Their photophysics and transient difference absorption properties as well as DFT calculations suggest these compounds may be used as optical limiting material.

[Full Paper]
Guangliang Song, Rui Liu, Guangke He, Shidong Yuan, Hongjun Zhu
Asian J. Org. Chem. 2015, 4, No. 4, 346. Read article.

Synthetic Strategies for Oligoynes

Synthetic Strategies for Oligoynes

How long can you go? Conjugated oligoynes can be prepared in various ways, ranging from metal-catalyzed couplings of terminal alkynes and 1-haloalkynes to rearrangement reactions, such as the Fritsch-Buttenberg-Wiechell (FBW) reaction, to scaffolding with diethynylethenes as masked hexatriynes. Oligoyne stability can be enhanced by bulky end groups, whereas enhanced stability of terminal acetylene building blocks can be achieved by gold(I) end-caps.

[Focus Review]
Martyn Jevric, Mogens Brøndsted Nielsen
Asian J. Org. Chem. 2015, 4, No. 4, 286. Read article.

First Total Synthesis of Piperenol B and Configuration Revision of the Enantiomers Piperenol B and Uvarirufol A

First Total Synthesis of Piperenol B and Configuration Revision of the Enantiomers Piperenol B and Uvarirufol A

The first total synthesis of piperenol B, a polyoxygenated cyclohexene natural product from Piper cubeb, has been developed starting with the multi-ten-gram scale enzymatic dihydroxylation of sodium benzoate. The originally predicted absolute configurations of piperenol B and its enantiomer uvarirufol A were eventually revised based on this synthesis and NMR analysis of late-stage Mosher's esters.

[Full Paper]
Thomas C. Fischer, Bruno Cerra, Michael J. Fink, Florian Rudroff, Ernst Horkel, Marko D. Mihovilovic
Eur. J. Org. Chem. 2015, No. 7, 1464. Read article.

Supramolecular Architectures Incorporating Hydrogen-Bonding Barbiturate Receptors

Supramolecular Architectures Incorporating Hydrogen-Bonding Barbiturate Receptors

Good hosts: An overview of Hamilton-type bis(amidopyridine) receptor motifs, which offer strong and selective binding in non-competitive media for barbiturates and cyanurates, leading to a wide range of supramolecular assemblies, is presented. A particular emphasis is placed on photoaddressable systems.

[Focus Review]
Arnaud Tron, Mathias Rocher, Peter J. Thornton, James H. R. Tucker, Nathan D. McClenaghan
Asian J. Org. Chem. 2015, 4, No. 3, 192. Read article.

Tampering with Cell Division by Using Small-Molecule Inhibitors of CDK–CKS Protein Interactions

Tampering with Cell Division by Using Small-Molecule Inhibitors of CDK–CKS Protein Interactions

Two small-molecule inhibitors of CDK–CKS protein interactions were discovered. They bind to CDK2 and they do not inhibit its kinase activity. They inhibit the proliferation of tumor cell lines. They cause a decrease in CDK2/cyclin A and p27Kip1 expression levels.

[Full Paper]
Amel Hamdi, Aurélien Lesnard, Peggy Suzanne, Thomas Robert, Maria A. Miteva, Morgan Pellerano, Bruno Didier, Elizabeth Ficko-Blean, Annelise Lobstein, Marcel Hibert, Sylvain Rault, May C. Morris, Pierre Colas
ChemBioChem 2015, 16, No. 3, 432. Read article.

Highly Fluorinated Tris(indazolyl)borate Silylamido Complexes of the Heavier Alkaline Earth Metals: Synthesis, Characterization, and Efficient Catalytic Intramolecular Hydroamination

Highly Fluorinated Tris(indazolyl)borate Silylamido Complexes of the Heavier Alkaline Earth Metals: Synthesis, Characterization, and Efficient Catalytic Intramolecular Hydroamination

Stabilized distortion: The highly fluorinated 3-phenyl hydrotris(indazolyl)borate ligand {F12-Tp4Bo, 3Ph} coordinates the Ca and Sr metals to afford the heteroleptic silylamido derivatives [(F12-Tp4Bo, 3Ph)Ae{N(SiMe2R)2}] (Alkaline earth metal (Ae)=Ca, Sr, R=Me; Ae=Ca, R=H). Agostic distortions, which are especially strong for Sr, stabilize the structures (see figure). The complexes containing the {N(SiMe3)2} ligand catalyze the cyclohydroamination of aminoalkenes. The synthesis of the new homoleptic unsolvated [Ca{N(SiMe2H)2}2] precursor is also described.

[Full Paper]
Nuria Romero, Sorin-Claudiu Roşca, Yann Sarazin, Jean-François Carpentier, Laure Vendier, Sonia Mallet-Ladeira, Chiara Dinoi, Michel Etienne
Chem. Eur. J. 2015, 21, No. 10, 4115. Read article.

Deprotonation of Coordinated Phosphanes in a Rhenium Complex: C-C Coupling with Diimine Coligands

Deprotonation of Coordinated Phosphanes in a Rhenium Complex: C-C Coupling with Diimine Coligands

Re-joined: C-C coupling between phosphane and diimine ligands takes place when rhenium complexes are treated with a strong base. Treatment of fac-[Re(bipy)(CO)3(PMe3)][OTf] with KN(SiMe3)2 is shown to cause deprotonation of a methyl group, resulting in a bond formation between a P-bonded methylene group and the C6 position of 2,2'-bipyridine (bipy). (iPr2BIAN=1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene).

[Communication]
Rebeca Arévalo, Julio Pérez, Lucía Riera
Chem. Eur. J. 2015, 21, No. 9, 3546. Read article.

Generation and Trapping of Ketenes in Flow

Generation and Trapping of Ketenes in Flow

Ketenes are generated under flow conditions by thermal sigmatropic rearrangement of alkoxyalkynes. Subsequent trapping with amines or alcohols gives amide or ester products, respectively. Inline monitoring by IR spectroscopy and offline analysis by 1H NMR spectroscopy allow the rapid study of kinetics and optimisation of the reaction.

[Full Paper]
Cyril Henry, David Bolien, Bogdan Ibanescu, Sally Bloodworth, David C. Harrowven, Xunli Zhang, Andy Craven, Helen F. Sneddon, Richard J. Whitby
Eur. J. Org. Chem. 2015, No. 7, 1491. Read article.

Epimerization at C-3'' in Butirosin Biosynthesis by an NAD+-Dependent Dehydrogenase BtrE and an NADPH-Dependent Reductase BtrF

Epimerization at C-3'' in Butirosin Biosynthesis by an NAD+-Dependent Dehydrogenase BtrE and an NADPH-Dependent Reductase BtrF

E and F, you complete me: Two NAD(P)-dependent oxidoreductases, BtrE/BtrF, were found to catalyze the C-3'' epimerization of ribostamycin and xylostasin through a 3''-oxoribostamycin intermediate. BtrE/BtrF strictly recognize pseudo-trisaccharide structures and the stereochemistry of the pentose moieties. This two-step epimerization mechanism may be present in many other natural product biosynthetic pathways.

[Full Paper]
Ryohei Takeishi, Fumitaka Kudo, Mario Numakura, Tadashi Eguchi
ChemBioChem 2015, 16, No. 3, 487. Read article.

How a [CoIV${^{\underline{.....}}}$O]2+ Fragment Oxidizes Water: Involvement of a Biradicaloid [CoII–(·O·)]2+ Species in Forming the O-O Bond

How a [CoIV${^{\underline{.....}}}$O]2+ Fragment Oxidizes Water: Involvement of a Biradicaloid [CoII–(·O·)]2+ Species in Forming the O-O Bond

Quantum leap: Quantum chemical models based on density functional theory are used to study the mechanism of water oxidation performed by a recently discovered cobalt complex (Py5=2,6-(bis(bis-2-pyridyl)-methoxymethane)pyridine). It was shown that the most catalytically active species is the intermediate-spin quartet complex that is almost isoenergetic with the doublet state.

[Full Paper]
Douglas W. Crandell, Soumya Ghosh, Curtis P. Berlinguette, Mu-Hyun Baik
ChemSusChem 2015, 8, No. 5, 844. Read article.

Fabrication of Hierarchical Fe3O4@SiO2@P(4VP-DVB)@Au Nanostructures and Their Enhanced Catalytic Properties

Fabrication of Hierarchical Fe3O4@SiO2@P(4VP-DVB)@Au Nanostructures and Their Enhanced Catalytic Properties

Gold digger: A poly(4-vinylpyridine) (P4VP) shell was coated on core–shell Fe3O4@SiO2 nanospheres followed by in situ embedding of gold nanoparticles homogeneously into the P4VP chains to obtain the nanocatalyst (see figure). The P4VP shell, easily swollen by the reactants, made the embedded gold nanoparticles easily accessible to the reactants and prevented them from coagulating.

[Full Paper]
Wanchun Guo, Qian Wang, Yi Luan, Ge Wang, Wenjun Dong, Jie Yu
Chem. Asian J. 2015, 10, No. 3, 701. Read article.

Synthesis of 3'-Fluoro-tRNA Analogues for Exploring Non-ribosomal Peptide Synthesis in Bacteria

Synthesis of 3'-Fluoro-tRNA Analogues for Exploring Non-ribosomal Peptide Synthesis in Bacteria

Fluorinated aminoacyl-tRNA analogues: Semisynthetic routes to fluoro analogues of tRNAAla and Ala-tRNAAla have been developed. These molecules are non-isomerisable analogues of the substrates of alanyl-tRNA synthetases and FemX transferases and should provide new insight into substrate recognition by these enzymes.

[Full Paper]
Laura Iannazzo, Guillaume Laisné, Matthieu Fonvielle, Emmanuelle Braud, Jean-Philippe Herbeuval, Michel Arthur, Mélanie Etheve-Quelquejeu
ChemBioChem 2015, 16, No. 3, 477. Read article.

The Role of Metal Halides in Enhancing the Dehydration of Xylose to Furfural

The Role of Metal Halides in Enhancing the Dehydration of Xylose to Furfural

Get your kicks from kinetics: The effect of metal halides on the mechanism and kinetics of xylose dehydration in aqueous solution have been investigated. We found that both the rate of xylose consumption and furfural selectivity are affected by the nature of the salt cation and anion pairing.

[Full Paper]
Kristopher R. Enslow, Alexis T. Bell
ChemCatChem 2015, 7, No. 3, 479. Read article.

Light-Triggered Capture and Release of DNA and Proteins by Host–Guest Binding and Electrostatic Interaction

Light-Triggered Capture and Release of DNA and Proteins by Host–Guest Binding and Electrostatic Interaction

Cyclodextrin vesicles bind charged biomolecules, such as DNA or proteins, in the presence of light-responsive charged guest molecules. The complexes can be disassembled under UV-light irradiation based on trans/cis isomerization of the azobenzene guests (see figure).

[Full Paper]
Johanna Moratz, Avik Samanta, Jens Voskuhl, Siva Krishna Mohan Nalluri, Bart Jan Ravoo
Chem. Eur. J. 2015, 21, No. 8, 3271. Read article.

Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors

Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors

Sweet 17 vs. 20S: Seventeen furan-based peptidic molecules were designed and synthesized as 20S proteasome inhibitors, some of which showed potency and selectivity for the β5 subunit in both enzymatic and cell-based assays. Good antineoplastic activities were observed in multiple tumor cell lines. Docking and molecular dynamics simulations were also used to confirm a noncovalent binding mode.

[Full Paper]
Qi Sun, Bo Xu, Yan Niu, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin, Ping Xu
ChemMedChem 2015, 10, No. 3, 498. Read article.

From Amino Acids to Fluorine-Containing Carbohydrates: De Novo Synthesis of 2-Amino-4-Fluoroxylose and -lyxose

From Amino Acids to Fluorine-Containing Carbohydrates: De Novo Synthesis of 2-Amino-4-Fluoroxylose and -lyxose

Fluorinated derivatives of amino-xylose and -lyxose have been prepared by aldolization of D- and L-cysteine-derived aldehydes and a fluoroacetyl ephedrine oxazolidinone auxiliary. Photochemical Pummerer-type rearrangement followed by acidic cleavage of the protecting groups subsequently furnished the title compounds in overall yields of 47–48 % over four steps.

[Full Paper]
Christopher Albler, Walther Schmid
Eur. J. Org. Chem. 2015, No. 6, 1314. Read article.

Linked Supramolecular Building Blocks for Enhanced Cluster Formation

Linked Supramolecular Building Blocks for Enhanced Cluster Formation

The butterfly effect: Calix[4]arenes are versatile structural supports for polymetallic clusters possessing fascinating magnetic properties. Bis-calix[4]arene is shown to offer enhanced control over the assembly of such species, and a rational approach towards the targeted synthesis of complex and challenging structures.

[Full Paper]
Ross McLellan, Maria A. Palacios, Christine M. Beavers, Simon J. Teat, Stergios Piligkos, Euan K. Brechin, Scott J. Dalgarno
Chem. Eur. J. 2015, 21, No. 7, 2804. Read article.

A Highly Resilient Mesoporous SiOx Lithium Storage Material Engineered by Oil–Water Templating

A Highly Resilient Mesoporous SiOx Lithium Storage Material Engineered by Oil–Water Templating

All's well with oil: Carbon-coated porous SiOx is synthesized by a facile and scalable approach, that is, a sol–gel reaction of hydrogen silsesquioxane together using oil–water templating. A hydrophobic oil is used as both, a pore former inside the SiOx matrix and a precursor for carbon encapsulation on the surface of SiOx. The resulting anode material exhibits a high reversible capacity and outstanding cycling performance over 100 cycles without significant dimensional changes.

[Full Paper]
Eunjun Park, Min-Sik Park, Jaewoo Lee, Ki Jae Kim, Goojin Jeong, Jung Ho Kim, Young-Jun Kim, Hansu Kim
ChemSusChem 2015, 8, No. 4, 688. Read article.

Bifunctional N-Heterocyclic Carbene Ferrocenyl Ligands – Synthesis and Palladium(II) Complexes

Bifunctional N-Heterocyclic Carbene Ferrocenyl Ligands – Synthesis and Palladium(II) Complexes

Two ferrocenylimidazolium tetrafluoroborate salts, precursors of new ferrocenylimidazol-2-ylidene bifunctional ligands, and the corresponding palladium(II) complexes have been prepared for the first time.

[Full Paper]
Pauline Loxq, Jean-Claude Daran, Eric Manoury, Rinaldo Poli, Agnès Labande
Eur. J. Inorg. Chem. 2015, No. 4, 609. Read article.

A Ring-Flippable Sugar as a Stimuli-Responsive Component of Liposomes

A Ring-Flippable Sugar as a Stimuli-Responsive Component of Liposomes

Molecular switch assembly: A ring-flippable sugar is applied in switching of linear–bent lipid structures in a stimuli-responsive manner. In water, the synthesized lipid and a fluorescent probe form solid micelles. Upon addition of Zn2+, the micelles transformed into liposomes that incorporated the probe, which was released by adding H+ (see figure).

[Full Paper]
Junji Takeuchi, Akihiro Ohkubo, Hideya Yuasa
Chem. Asian J. 2015, 10, No. 3, 586. Read article.

Mechanism of Brnsted Acid-Catalyzed Glucose Dehydration

Mechanism of Brønsted Acid-Catalyzed Glucose Dehydration

Glucose dehydration: The DFT-based microkinetic modeling of the Brønsted acid-catalyzed dehydration of glucose is in excellent agreement with experimental kinetic data. The rate-limiting step is the first dehydration of protonated glucose. Isotopic tracing NMR spectroscopy reveals that glucose dehydrates through a cyclic path and the majority of glucose is consumed by the 5-hydroxymethylfurfural intermediate at low conversions.

[Full Paper]
Liu Yang, George Tsilomelekis, Stavros Caratzoulas, Dionisios G. Vlachos
ChemSusChem 2015, 8, No. 8, 1334. Read article.

Ruthenium Oxide-Doped TiO2 Nanotubes by Single-Step Anodization for Water-Oxidation Applications

Ruthenium Oxide-Doped TiO2 Nanotubes by Single-Step Anodization for Water-Oxidation Applications

Thicker walls and longer tubes: High-aspect-ratio TiO2 nanotubes with a doping of ruthenium oxide have been prepared by single anodization in an electrolyte containing KRuO4 and H2O. The additives act as a source of dopant and supporting electrolyte, leading to thickening of the nanotube walls. As a result, ruthenium oxide-doped TiO2 nanotubes with longer nanotubes are achievable and could be successfully used as water-oxidation electrodes.

[Full Paper]
Hyeonseok Yoo, Yong-Wook Choi, Jinsub Choi
ChemCatChem 2015, 7, No. 4, 643. Read article.

Simultaneous Genotyping of Multiple Somatic Mutations by Using a Clamping PNA and PNA Detection Probes

Simultaneous Genotyping of Multiple Somatic Mutations by Using a Clamping PNA and PNA Detection Probes

A novel method of simultaneous detection of multiple mutations and a melting curve analysis was developed using clamping PNA/detection PNA probes. Each PNA probe was designed to have a specific melting temperature by the introduction of γ-PNA monomers. This technique was successfully applied to the detection of six genotypes in two different mutations of K-RAS at the same time.

[Communication]
Yong-Tae Kim, Jin Woo Kim, Sung Kee Kim, Goon Ho Joe, In Seok Hong
ChemBioChem 2015, 16, No. 2, 209. Read article.

A Visible-Light Harvesting System for CO2 Reduction Using a RuII–ReI Photocatalyst Adsorbed in Mesoporous Organosilica

A Visible-Light Harvesting System for CO2 Reduction Using a RuII–ReI Photocatalyst Adsorbed in Mesoporous Organosilica

Light my CO2: A photocatalytic system for CO2 reduction exhibiting visible-light harvesting is developed by preparing a hybrid consisting of a RuII-ReI complex as photocatalyst and a periodic mesoporous organosilica as light harvester. The light-harvesting ability of the hybrid enhances the photocatalytic activity for CO evolution by a factor of up to ten.

[Communication]
Yutaro Ueda, Hiroyuki Takeda, Tatsuto Yui, Kazuhide Koike, Yasutomo Goto, Shinji Inagaki, Osamu Ishitani
ChemSusChem 2015, 8, No. 3, 439. Read article.

Through the Maze: Cross-Coupling Pathways to a Helical Hexaphenyl “Geländer” Molecule

Through the Maze: Cross-Coupling Pathways to a Helical Hexaphenyl “Geländer” Molecule

The synthesis of a helical, interlinked Geländer (banister) type hexaphenyl oligomer is symbolized in the figure as a maze; this is a representation of both the often convoluted synthetic possibilities as well as the successful resolution of the maze to reach the target structure.

[Full Paper]
Michel Rickhaus, Linda Maria Bannwart, Oliver Unke, Heiko Gsellinger, Daniel Häussinger, Marcel Mayor
Eur. J. Org. Chem. 2015, No. 4, 786. Read article.

Assessment of the 3 D Pore Structure and Individual Components of Preshaped Catalyst Bodies by X-Ray Imaging

Assessment of the 3 D Pore Structure and Individual Components of Preshaped Catalyst Bodies by X-Ray Imaging

Catalyst bodies in 3 D: The assessment of the 3 D pore structure and components of catalyst bodies in the nanoscale is crucial to understand the fluid catalytic-cracking process (FCC). Modern X-ray imaging techniques allow visualization and quantification of the 3 D pore structure, as well as the material components of FCC catalyst bodies, at this critical scale. These techniques help to improve the manufacture of these catalyst bodies by tuning the pore size and connectivity in a controlled manner.

[Communication]
Julio C. da Silva, Kevin Mader, Mirko Holler, David Haberthür, Ana Diaz, Manuel Guizar-Sicairos, Wu-Cheng Cheng, Yuying Shu, Jörg Raabe, Andreas Menzel, Jeroen A. van Bokhoven
ChemCatChem 2015, 7, No. 3, 413. Read article.

Investigating the Anti-leishmanial Effects of Linear Peptoids

Investigating the Anti-leishmanial Effects of Linear Peptoids

L. mex. meets its match: Peptoids—a class of peptide mimetics—have demonstrated their activities against a range of bacterial infections. In this work, we studied the anti-leishmanial properties of linear peptoids, which were observed to have promising activity against Leishmania mexicana axenic amastigotes, a causative agent of cutaneous leishmaniasis.

[Communication]
Gabriela A. Eggimann, Hannah L. Bolt, Paul W. Denny, Steven L. Cobb
ChemMedChem 2015, 10, No. 2, 233. Read article.

Expeditious Synthesis of Enantiopure, Orthogonally Protected Bis-α-Amino Acids (OPBAAs) and their Use in a Study of Nod1 Stimulation

Expeditious Synthesis of Enantiopure, Orthogonally Protected Bis-α-Amino Acids (OPBAAs) and their Use in a Study of Nod1 Stimulation

Give it a nod: A concise preparation of structurally diverse OPBAAs bearing three orthogonally protecting groups and a spacer of varied length has been developed. Using these versatile building blocks, a series of small peptides inspired from peptidoglycan fragments were synthesized and then studied for their ability to activate human Nod1 receptor in the innate immune response through the NF-κB pathway.

[Full Paper]
Po-Ting Chen, Cheng-Kun Lin, Chih-Ju Tsai, Duen-Yi Huang, Fu-Yao Nien, Wan-Wan Lin, Wei-Chieh Cheng
Chem. Asian J. 2015, 10, No. 2, 474. Read article.

Crystal Structures and Redox Responses Coupled with Ion Recognition of p-Benzoquinone- and Hydroquinone-Fused [18]crown-6

Crystal Structures and Redox Responses Coupled with Ion Recognition of p-Benzoquinone- and Hydroquinone-Fused [18]crown-6

Like jewels in a crown: Crystal structures of p-benzoquinone (BQ)- and hydroquinone-fused [18]crown-6 derivatives were investigated. The redox properties of BQ-fused [18]crown-6 derivatives, coupled with ion capturing, were dominated by electrostatic interactions and the solvation energy.

[Full Paper]
Takayuki Kobayashi, Yuta Nakane, Takashi Takeda, Norihisa Hoshino, Hidetoshi Kawai, Tomoyuki Akutagawa
Chem. Asian J. 2015, 10, No. 2, 390. Read article.

New Catalyst Series from the Sol–Gel-Entrapment of Gold Nanoparticles in Organically Modified Silica Matrices: Proof of Performance in a Model Oxidation Reaction

New Catalyst Series from the Sol–Gel-Entrapment of Gold Nanoparticles in Organically Modified Silica Matrices: Proof of Performance in a Model Oxidation Reaction

Time for gold catalysis to get real: The subtle encapsulation of gold nanoparticles in sol–gel organosilica opens the route to effective heterogeneous oxidation catalysts. The fine-tuneable hydrophilic and hydrophobic regions around the active metal site, the exceptionally high inner mesoporosity, and the enhanced chemical and physical stability of the organosilica matrix indicate forthcoming practical applications of redox catalysis based on gold.

[Full Paper]
Rosaria Ciriminna, Alexandra Fidalgo, Valerica Pandarus, François Béland, Laura M. Ilharco, Mario Pagliaro
ChemCatChem 2015, 7, No. 2, 254. Read article.

Promiscuity and the Conformational Rearrangement of Drug-Like Molecules: Insight from the Protein Data Bank

Promiscuity and the Conformational Rearrangement of Drug-Like Molecules: Insight from the Protein Data Bank

Promiscuity in the PDB: A dataset was prepared from 100 drug-like ligands found crystallized in multiple PDB structures that bind to a pair of biological targets with similar in vitro affinity. Compounds were less likely to change conformation upon binding to different proteins if they were highly ligand efficient and had few rotatable bonds. These findings have implications for medicinal chemistry strategies to improve ligand selectivity profiles.

[Communication]
Michael W. He, Patrick S. Lee, Zachary K. Sweeney
ChemMedChem 2015, 10, No. 2, 238. Read article.

Improved Sensitivity for Imaging Spin Trapped Hydroxyl Radical at 250 MHz

Improved Sensitivity for Imaging Spin Trapped Hydroxyl Radical at 250 MHz

Three's a charm: Reactive oxygen species can be detected by spin trapping. Previously high detection limits at the low frequencies required for in vivo EPR imaging are dramatically reduced by combining three enabling technologies: the spin-trap BMPO, rapid-scan EPR and a new image reconstruction algorithm, and demonstrated by a 2D spectral spatial image of 5 μM BMPO–OH.

[Communication]
Joshua R. Biller, Mark Tseitlin, Deborah G. Mitchell, Zhelin Yu, Laura A. Buchanan, Hanan Elajaili, Gerald M. Rosen, Joseph P. Y. Kao, Sandra S. Eaton, Gareth R. Eaton
ChemPhysChem 2015, 16, No. 3, 528. Read article.

Using Click Chemistry to Tune the Properties and the Fluorescence Response Mechanism of Structurally Similar Probes for Metal Ions

Using Click Chemistry to Tune the Properties and the Fluorescence Response Mechanism of Structurally Similar Probes for Metal Ions

In these scorpionand molecular probes, the triazole connectivity, the carbon linker, and the fluorescent tail all combine to modulate photophysical behavior and metal responsiveness.

[Full Paper]
Sandra Ast, Stefanie Kuke, Peter J. Rutledge, Matthew H. Todd
Eur. J. Inorg. Chem. 2015, No. 1, 58. Read article.

Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases

Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases

FxxA in the crosshairs: Herein we report two lead series of small molecules chemically elaborated from indole-containing fragments that bind to the surface of a humanised RAD51 orthologue. Our most potent compounds possess single-digit micromolar potency and target the FxxA binding site of the protein–protein interaction with BRCA2.

[Full Paper]
Duncan E. Scott, Anthony G. Coyne, Ashok Venkitaraman, Tom L. Blundell, Chris Abell, Marko Hyvönen
ChemMedChem 2015, 10, No. 2, 296. Read article.

An Efficient Catalytic Approach for the Synthesis of Unsymmetrical Siloxanes

An Efficient Catalytic Approach for the Synthesis of Unsymmetrical Siloxanes

An efficient methodology for the synthesis of unsymmetrical disiloxanes by means of catalytic one-pot hydrolysis/O-silylation of alkoxysilanes with allylsilanes (via silanol intermediates) in the presence of scandium(III) trifluoromethanesulfonate under mild conditions is described. Unsaturated siloxane products are used as substrates for further functionalization through the catalytic hydrosilylation reaction.

[Full Paper]
Grzegorz Hreczycho
Eur. J. Inorg. Chem. 2015, No. 1, 67. Read article.

Cinnamate-Functionalized Cage Silsesquioxanes as Photoreactive Nanobuilding Blocks

Cinnamate-Functionalized Cage Silsesquioxanes as Photoreactive Nanobuilding Blocks

From potassium cinnamate, photoreactive mono-, octa-, and deca(propyl cinnamate)-functionalized cage silsesquioxanes are synthesized by simple nucleophilic substitution reactions with chloropropyl-substituted octasilsesquioxanes. Among them, octa(propyl cinnamate)silsesquioxane exhibits excellent properties such as high photopolymerization conversion of double bonds and thermal stability.

[Full Paper]
Wenyan Yang, Yanchang Gan, Xuesong Jiang, Hongzhi Liu
Eur. J. Inorg. Chem. 2015, No. 1, 99. Read article.

An Electron-Deficient Small Molecule Accessible from Sustainable Synthesis and Building Blocks for Use as a Fullerene Alternative in Organic Photovoltaics

An Electron-Deficient Small Molecule Accessible from Sustainable Synthesis and Building Blocks for Use as a Fullerene Alternative in Organic Photovoltaics

A blueprint for the sustainable synthesis of electron-accepting small molecules as fullerene alternatives in organic photovoltaics is presented.

[Article]
Seth M. McAfee, Jessica M. Topple, Abby-Jo Payne, Jon-Paul Sun, Ian G. Hill, Gregory C. Welch
ChemPhysChem 2015, 16, No. 6, 1190. Read article.

p-Element-Doped Graphene: Heteroatoms for Electrochemical Enhancement

p-Element-Doped Graphene: Heteroatoms for Electrochemical Enhancement

Process matters: Doping of graphene with heteroatoms, namely boron, nitrogen, phosphorus, sulfur, fluorine, chlorine, bromine, and iodine, changes its electrochemical properties. Here, the different routes currently available for doping are discussed, and the influence upon the electrochemical properties of such materials is shown.

[Minireview]
Hwee Ling Poh, Martin Pumera
ChemElectroChem 2015, 2, No. 2, 190. Read article.

Supercapacitor Electrodes Based on Three-Dimensional Copper Structures with Precisely Controlled Dimensions

Supercapacitor Electrodes Based on Three-Dimensional Copper Structures with Precisely Controlled Dimensions

Layer it on thick: Deterministically engineered, three-dimensional Cu architectures serving as low-resistance current collectors for supercapacitor applications are fabricated through microfabrication and electrochemical techniques. These techniques enable the realization of high-performance electrodes with precisely controlled characteristic dimensions including the surface area, thickness of the active material, and interlayer spacing.

[Article]
Andac Armutlulu, Lawrence A. Bottomley, Sue Ann Bidstrup Allen, Mark G. Allen
ChemElectroChem 2015, 2, No. 2, 236. Read article.

The Generation Effect: Cavity Accessibility in Dense-Shell Polyphenylene Dendrimers

The Generation Effect: Cavity Accessibility in Dense-Shell Polyphenylene Dendrimers

It's all relative: The confined geometry of polyphenylene dendrimers leads to a clear generation effect because the size and access to the voids in these dendrimers is determined by their generation. Host–guest behavior to benzene, toluene, and xylenes (BTX) analytes was investigated by using quartz crystal microbalances.

[Communication]
Malte Brutschy, René Stangenberg, Cornelia Beer, Daniel Lubczyk, Martin Baumgarten, Klaus Müllen, Siegfried R. Waldvogel
ChemPlusChem 2015, 80, No. 1, 54. Read article.

Boosting Activation of Oxygen Molecules on C60 Fullerene by Boron Doping

Boosting Activation of Oxygen Molecules on C60 Fullerene by Boron Doping

B enhanced: Density functional calculations suggest that boron-doped fullerene C60 shows excellent performance in catalyzing the activation of oxygen molecules and the relative oxygen reduction reaction (see figure).

[Article]
Qiao-Zhi Li, Jia-Jia Zheng, Jing-Shuang Dang, Xiang Zhao
ChemPhysChem 2015, 16, No. 2, 390. Read article.

Exploring the Free Energy and Conformational Landscape of tRNA at High Temperature and Pressure

Exploring the Free Energy and Conformational Landscape of tRNA at High Temperature and Pressure

RNA under pressure! Exploration of the conformational and free-energy landscape of the 76-residue yeast phenylalanine transfer RNA (tRNAPhe; see figure) reveals that RNA unfolding differs not only from protein unfolding but also from DNA melting. Compared with the pronounced temperature effect, pressure-dependent changes in the secondary structure of tRNAPhe are small, however, even up to the 1000 MPa range.

[Article]
Caroline Schuabb, Melanie Berghaus, Christopher Rosin, Roland Winter
ChemPhysChem 2015, 16, No. 1, 138. Read article.

Electrochemical Conversion of CO2 into Negative Electrode Materials for Li-Ion Batteries

Electrochemical Conversion of CO2 into Negative Electrode Materials for Li-Ion Batteries

Capture the energy: CO2 was captured in molten LiCl–Li2CO3 salt and subsequently converted into amorphous carbon on the cathode and oxygen gas on the inert anode. The obtained carbon displays good performance as a negative electrode material for Li-ion batteries, thus demonstrating the feasibility of this energy conversion and storage process.

[Article]
Jianbang Ge, Liwen Hu, Wei Wang, Handong Jiao, Shuqiang Jiao
ChemElectroChem 2015, 2, No. 2, 224. Read article.

Voltage-Dependent Capacitance, Aging Effects, and Failure Indicators of Double-Layer Capacitors during Lifetime Testing

Voltage-Dependent Capacitance, Aging Effects, and Failure Indicators of Double-Layer Capacitors during Lifetime Testing

The age test: Aging phenomena, which occur during long-term cycling tests of so-called supercapacitors, complicate the exact determination of capacitance. Voltammetric methods allow useable capacitance, unwanted residual charges, and mechanical failure causes to be distinguished. Polymer-bound carbon electrodes show unexpected failure phenomena at high temperatures and voltages.

[Article]
Peter Kurzweil, Bernhard Frenzel, Andreas Hildebrand
ChemElectroChem 2015, 2, No. 1, 160. Read article.

Mechanistic Details of the Membrane Perforation and Passive Translocation of TAT Peptides

Mechanistic Details of the Membrane Perforation and Passive Translocation of TAT Peptides

The worm turns: How does the TAT peptide translocate across a mammalian cell membrane? Three biophysical methods, which can spatially resolve scales from millimeter (quartz crystal microbalance with dissipation (QCM-D)) and micrometer (scanning electrochemical microscopy (SECM)) to nanometer (AFM), provide evidence for wormhole-like pores (see figure). The SECM image shows that these pores allow redox mediators to pass through to the sensor, but TAT disrupts bacterial-mimetic membranes.

[Full Paper]
Stefania Piantavigna, Muhammad E. Abdelhamid, Chuan Zhao, Xiaohu Qu, George A. McCubbin, Bim Graham, Leone Spiccia, Anthony P. O'Mullane, Lisandra L. Martin
ChemPlusChem 2015, 80, No. 1, 83. Read article.

Facile Synthesis of Copper-Based Metal Oxide Nanoparticles with Exceptional Catalytic Activity for the Selective Oxidation of Styrenes into Benzaldehydes

Facile Synthesis of Copper-Based Metal Oxide Nanoparticles with Exceptional Catalytic Activity for the Selective Oxidation of Styrenes into Benzaldehydes

Talkin' about our generation: Copper-based metal oxide (CuO, CuO/Co3O4) nanoparticles have been synthesized from coordination-driven self-assembling aggregates and calcination treatment. They exhibited exceptional catalytic activity and stability for the selective oxidation of styrene and its derivatives to generate the corresponding aldehydes (see figure; TBHP=tert-butyl hydroperoxide).

[Full Paper]
Danhua Ge, Jiaqing Wang, Hongbo Geng, Shuanglong Lu, Dongtao Wang, Xinming Li, Xianli Zhao, Xueqin Cao, Hongwei Gu
ChemPlusChem 2015, 80, No. 3, 511. Read article.

Size-Induced Chiral Discrimination Switching by (S)-(−)-2(α-Hydroxyethyl)Benzimidazole-Derived Azacrowns

Size-Induced Chiral Discrimination Switching by (S)-(−)-2(α-Hydroxyethyl)Benzimidazole-Derived Azacrowns

Switching sides: The size of a chiral azacrown rather than the configuration of the chiral center/s in the hosts is the dominant influence on the enantioselective binding of guests. Thus, S-(−)-2(α-hydroxyethyl)benzimidazole-derived [15]crown-5 azacrown exhibit a preference for the S enantiomer of amino guests, whereas S-(−)-2(α-hydroxyethyl)benzimidazole-derived [18]crown-6 azacrowns exhibit a preference for the R enantiomer (see scheme).

[Communication]
Anita D. Pandey, Hasan Mohammed, Raghuvir R. S. Pissurlenkar, Anil V. Karnik
ChemPlusChem 2015, 80, No. 3, 475. Read article.