Mission Statement

The Asian Chemical Editorial Society (ACES) is an organization of 13 major chemical societies in Asia and the Pacific. It was founded in 2005 as a conglomeration of chemical societies with the mutual aim of creating a modern publishing forum for research in Asia and coordinating future publishing activities.

The participating societies share a commitment to scientific excellence, to publishing ethics, and to the highest standards in publication, which are the basis for the success of Chemistry—An Asian Journal and its associated journals.

Publications

Chemistry—An Asian Journal

A sister journal of Angewandte Chemie and Chemistry—A European Journal

Supporting Organizations: ChemPubSoc Europe, Gesellschaft Deutscher Chemiker (German Chemical Society, GDCh), Federation of Asian Chemical Societies (FACS).

Asian Journal of Organic Chemistry

A sister journal of the European Journal of Organic Chemistry

For the publication of the AsianJOC, ACES is joined by the Korean Society of Organic Synthesis.

Supporting Organization: ChemPubSoc Europe

ACES supports the publication of the ChemPubSoc Europe journals Chemistry—A European Journal, the European Journal of Organic Chemistry, and ChemSusChem.

© Wiley-VCH 2012

Journals

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Chem Asian J

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Asian J Org Chem

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Angew Chem

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Chem Eur J

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Eur J Org Chem

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ChemSusChem

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Chem Rec

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Chin J Chem

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J Chin Chem Soc

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News

Editorials: New Developments

Chemistry - An Asian Journal Theresa Kueckmann
A Good Year
Chem. Asian J. 2014 9, 4.

Asian Journal of Organic ChemistryRichard Threlfall
There's an App for That
Asian J. Org. Chem. 2014 3, 3.

 

Research of the DayEditors' Choice: Spotlights

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A Photochromic Agonist for μ-Opioid Receptors

A Photochromic Agonist for μ-Opioid Receptors

Lighting up the opioid receptor: Photofentanyl-2 is a photochromic version of the well-known analgesic fentanyl. It is a potent agonist in the dark (or when illuminated with blue light) and loses activity when irradiated with UV light. It can be used to optically control the μ-opioid receptor, converting a G-protein-coupled receptor (GPCR) into a photoreceptor.

[Communication]
Matthias Schönberger, Dirk Trauner
Angew. Chem. Int. Ed. 2014, 53, No. 12, 3264. Read article.

Potential-Driven Chirality Manifestations and Impressive Enantioselectivity by Inherently Chiral Electroactive Organic Films

Potential-Driven Chirality Manifestations and Impressive Enantioselectivity by Inherently Chiral Electroactive Organic Films

A jolt upon recognition: Torsion in the electroactive backbone endows poly-heterocycle films with high chiroptical activity, which is reversibly tunable by the electric potential, and outstanding enantiorecognition capability with about 100 mV between two enantiomeric ferrocenyl amino probes, in any order, in alternating sequences, and as a racemate.

[Communication]
Francesco Sannicolò, Serena Arnaboldi, Tiziana Benincori, Valentina Bonometti, Roberto Cirilli, Lothar Dunsch, Włodzimierz Kutner, Giovanna Longhi, Patrizia R. Mussini, Monica Panigati, Marco Pierini, Simona Rizzo
Angew. Chem. Int. Ed. 2014, 53, No. 10, 2623. Read article.

Folding of Synthetic Homogeneous Glycoproteins in the Presence of a Glycoprotein Folding Sensor Enzyme

Folding of Synthetic Homogeneous Glycoproteins in the Presence of a Glycoprotein Folding Sensor Enzyme

Folded up: A flexible model to reproduce in vitro folding of a glycoprotein in the presence of UDP-glucose:glycoprotein glucosyltransferase (UGGT) in a mixture containing correctly folded, folding intermediates, and misfolded glycoproteins is described. The data demonstrates that UGGT can re-glucosylate all intermediates, thus indicating that UGGT inspects not only final folded products, but also the glycoprotein folding intermediates.

[Communication]
Simone Dedola, Masayuki Izumi, Yutaka Makimura, Akira Seko, Akiko Kanamori, Masafumi Sakono, Yukishige Ito, Yasuhiro Kajihara
Angew. Chem. Int. Ed. 2014, 53, No. 11, 2883. Read article.

Pillar[n]arenes—a Novel, Highly Promising Class of Macrocyclic Host Molecules

Pillar[n]arenes—a Novel, Highly Promising Class of Macrocyclic Host Molecules

Upstanding citizens: This Focus Review provides a survey of the preparation and the structures of pillar[n]arenes. A second focus concerns the possibilities of complexation of pillar[n]arenes and the selectivity of the process.

[Focus Review]
Derong Cao, Herbert Meier
Asian J. Org. Chem. 2014, 3, No. 3, 244. Read article.

Copper(I) Complexes of Phenanthro-Annulated N-Heterocyclic Carbenes: Synthesis and Transmetalation Reactions

Copper(I) Complexes of Phenanthro-Annulated N-Heterocyclic Carbenes: Synthesis and Transmetalation Reactions

Copper complexes with phenanthro-annulated N-heterocyclic carbene ligands were prepared from imidazolium salts and Cu2O. Initial transmetalation experiments with [RhCl(cod)] showed an equilibrium in most solvents. Two rhodium complexes could be prepared using acetonitrile as the solvent. One was prepared in a two phase mixture of chloroform and aqueous CaCl2.

[Full Paper]
Jaroslaw Mormul, Manfred Steimann, Ulrich Nagel
Eur. J. Inorg. Chem. 2014, No. 8, 1389. Read article.

Photonic Crystals for Chemical Sensing and Biosensing

Photonic Crystals for Chemical Sensing and Biosensing

Sense and sensitivity: Nature knew them for millions of years before they were rediscovered by mankind: photonic crystals. Some butterflies and beetles use them for mimicry and survival techniques, for example to distract predators. This Review describes the mode of action of photonic crystals as well as their application for the optical chemo- and biosensing of analytes, with a focus on the materials used.

[Review]
Christoph Fenzl, Thomas Hirsch, Otto S. Wolfbeis
Angew. Chem. Int. Ed. 2014, 53, No. 13, 3318. Read article.

Pyridine-N-Oxide 2-Carboxylic Acid: An Acceptor Group for Organic Sensitizers with Enhanced Anchoring Stability in Dye-Sensitized Solar Cells

Pyridine-N-Oxide 2-Carboxylic Acid: An Acceptor Group for Organic Sensitizers with Enhanced Anchoring Stability in Dye-Sensitized Solar Cells

A sensitive soul: A D-π-A organic dye carrying a pyridine-N-oxide 2-carboxylic acid anchoring group was synthesized and used as a sensitizer for TiO2. Desorption kinetics experiments demonstrated that the new dye adsorbs onto TiO2 more strongly than a classic cyanoacrylic-acid-containing dye. When used as a sensitizer in a dye-sensitized solar cell, the power conversion efficiency of the sensitizer was approximately 66 % of that of a reference dye.

[Full Paper]
Bianca Cecconi, Alessandro Mordini, Gianna Reginato, Lorenzo Zani, Maurizio Taddei, Fabrizia Fabrizi de Biani, Filippo De Angelis, Gabriele Marotta, Paolo Salvatori, Massimo Calamante
Asian J. Org. Chem. 2014, 3, No. 2, 140. Read article.

Enhanced Photoelectrochemical Water Splitting Efficiency of a Hematite–Ordered Sb:SnO2 Host–Guest System

Enhanced Photoelectrochemical Water Splitting Efficiency of a Hematite–Ordered Sb:SnO2 Host–Guest System

Being a good host: We form a well-defined nanoarchitecture of ATO as a host for hematite crystallites, and show its use as a photoanode for photoelectrochemical water splitting. The key improvement in photocurrent can be attributed to successful Sb doping of the SnO2 structure in combination with the high surface area provided by the 3D nanochannel geometry.

[Communication]
Lei Wang, Anna Palacios-Padrós, Robin Kirchgeorg, Alexei Tighineanu, Patrik Schmuki
ChemSusChem 2014, 7, No. 2, 421. Read article.

Macrocyclic Dyads Based on C60 and Perylenediimides Connected by Click Chemistry

Macrocyclic Dyads Based on C60 and Perylenediimides Connected by Click Chemistry

Fuller surprises: Two perylenediimide (PDI)-[60]fullerene macrocyclic dyads connected through 1,2,3-triazole units have been synthesized and characterized. A small interaction between the C60 and PDI units in the ground state was detected by UV/vis and electrochemical measurements in both PDI-C60 cyclic systems. The occurrence of photoinduced energy-transfer processes between PDI and C60 were confirmed by time-resolved emission and transient absorption techniques.

[Full Paper]
Sara Pla, Luis Martín-Gomis, Kei Ohkubo, Shunichi Fukuzumi, Fernando Fernández-Lázaro, Angela Sastre-Santos
Asian J. Org. Chem. 2014, 3, No. 2, 185. Read article.

Hollow and Yolk-Shell Iron Oxide Nanostructures on Few-Layer Graphene in Li-Ion Batteries

Hollow and Yolk-Shell Iron Oxide Nanostructures on Few-Layer Graphene in Li-Ion Batteries

Running on empty: Hollow and yolk-shell iron oxide nanostructures supported on few-layer graphene (FLG) were found to be beneficial for the cycling stability in lithium-ion batteries, especially for electrodes with low carbon content (see figure). Further improvement of capacity retention upon cycling was achieved for composites with a hollow structure, obtaining retention values above 97 % after 120 cycles at 1000 mA g−1.

[Full Paper]
Zhenyu Sun, Kunpeng Xie, Zi An Li, Ilja Sinev, Petra Ebbinghaus, Andreas Erbe, Michael Farle, Wolfgang Schuhmann, Martin Muhler, Edgar Ventosa
Chem. Eur. J. 2014, 20, No. 7, 2022. Read article.

Towards Eumelanin@Zeolite Hybrids: Pore-Size-Controlled 5,6-Dihydroxyindole Polymerization

Towards Eumelanin@Zeolite Hybrids: Pore-Size-Controlled 5,6-Dihydroxyindole Polymerization

Confinement in nanometer-sized channels of zeolite L allowed the formation and stabilization of the quinonoid 5,6-dihydroxyindole dimer(s) as a precursor step to synthetic eumelanin-like polymers. The entrapped species were characterized by an integrated spectroscopic and computational approach. In mesoporous silica, the larger diameter of the channels determines the formation of black eumelanin-type materials.

[Full Paper]
Eko Adi Prasetyanto, Paola Manini, Alessandra Napolitano, Orlando Crescenzi, Marco d'Ischia, Luisa De Cola
Chem. Eur. J. 2014, 20, No. 6, 1597. Read article.

Synthesis of Water-Soluble Red-Emitting Thienyl–BODIPYs and Bovine Serum Albumin Labeling

Synthesis of Water-Soluble Red-Emitting Thienyl–BODIPYs and Bovine Serum Albumin Labeling

Red and water soluble: Highly fluorescent water-soluble thienyl-BODIPY dyes with quantum yields reaching 60 % were prepared by a facile synthesis by using dimethylaminopropyne, followed by quaternarization to the ammonium salt. When adequately engineered, such dyes could be used as fluorescent labels for covalent binding to proteins (see figure).

[Communication]
Arnaud Poirel, Pascal Retailleau, Antoinette De Nicola, Raymond Ziessel
Chem. Eur. J. 2014, 20, No. 5, 1252. Read article.

Molecular Design Exploiting a Fluorine gauche Effect as a Stereoelectronic Trigger

Molecular Design Exploiting a Fluorine gauche Effect as a Stereoelectronic Trigger

The fluorine gauche effect was used to control torsional rotation in fluorinated dimethylamino pyridine (DMAP) analogues. Upon “substrate binding” an electropositive nitrogen centre vicinal to the fluorine atom at a molecular hinge (F–Cβ–Cα–N+) triggers a conformational change akin to those induced in enzymatic systems. Catalysis experiments and kinetic and reactivity studies are disclosed.

[Full Paper]
Yannick P. Rey, Lucie E. Zimmer, Christof Sparr, Eva-Maria Tanzer, W. Bernd Schweizer, Hans Martin Senn, Sami Lakhdar, Ryan Gilmour
Eur. J. Org. Chem. 2014, No. 6, 1202. Read article.

Synthesis of the Aglycone of the Argelosides: Antiproliferative 14,15-seco-Pregnane Glycosides

Synthesis of the Aglycone of the Argelosides: Antiproliferative 14,15-seco-Pregnane Glycosides

To aromatize or not to aromatize: The synthesis of the argelosides aglycone, a unique compound consisting of a 14,15-seco-pregnane core with a highly-oxygenated cage-like moiety in the D, E, and F rings, was achieved. Although the strategy for the synthesis of the target molecule seemed simple, the primary challenge lay in handling the easy-to-aromatize β,γ-dihydroxyketone precursor as well as the diketal moiety of the target molecule under acidic conditions.

[Communication]
Minoru Tamiya, Nobuhisa Isaka, Takaki Kitazawa, Masaji Ishiguro
Asian J. Org. Chem. 2014, 3, No. 3, 264. Read article.

Hedycaryol Synthase in Complex with Nerolidol Reveals Terpene Cyclase Mechanism

Hedycaryol Synthase in Complex with Nerolidol Reveals Terpene Cyclase Mechanism

High-precision structure: The structure of the bacterial sesquiterpene synthase hedycaryol synthase from Kitasatospora setae in complex with the reaction intermediate analogue nerolidol was obtained at high resolution (1.5 Å). Detailed mechanistic principles for the late steps of terpene cyclisations were delineated and extensively tested by analysis of twelve site-specific mutants.

[Communication]
Philipp Baer, Patrick Rabe, Christian A. Citron, Carina C. de Oliveira Mann, Norman Kaufmann, Michael Groll, Jeroen S. Dickschat
ChemBioChem 2014, 15, No. 2, 213. Read article.

The Role of Molecular Dipole Orientation in Single-Molecule Fluorescence Microscopy and Implications for Super-Resolution Imaging

The Role of Molecular Dipole Orientation in Single-Molecule Fluorescence Microscopy and Implications for Super-Resolution Imaging

Orientation tour: Methods for determining the orientation of single molecules from fluorescence microscopy are reviewed (including those that produce the images pictured). The limits that molecular orientation imposes on single-molecule-based super-resolution microscopy are discussed. New data is presented, detailing the rotational mobility of fluorescent labels in a particular biological sample, namely microtubules immunolabeled with Alexa Fluor 647.

[Minireview]
Mikael P. Backlund, Matthew D. Lew, Adam S. Backer, Steffen J. Sahl, W. E. Moerner
ChemPhysChem 2014, 15, No. 4, 587. Read article.

DNA-Directed Assembly of Antibody–Fluorophore Conjugates for Quantitative Multiparametric Flow Cytometry

DNA-Directed Assembly of Antibody–Fluorophore Conjugates for Quantitative Multiparametric Flow Cytometry

Any color you like: Oligonucleotide-labeled antibodies and polyfluorophore constructs can be assembled to form fluorescent antibodies in any combination of fluorescent colors. The polyfluorophore-labeled antibodies can then be used for conventional staining of cells for flow cytometry and, when calibrated with polyfluorophore-labeled microspheres, for quantitative calculation of the number of antibodies bound per cell in a single- or multitarget assay.

[Full Paper]
Amy C. Flor, Jimmy H. Williams, Kelly M. Blaine, Ryan C. Duggan, Anne I. Sperling, David A. Schwartz, Stephen J. Kron
ChemBioChem 2014, 15, No. 2, 267. Read article.

Tripod Immobilization of Triphenylphosphane on a Silica-Gel Surface to Enable Selective Mono-Ligation to Palladium: Application to Suzuki–Miyaura Cross-Coupling Reactions with Chloroarenes

Tripod Immobilization of Triphenylphosphane on a Silica-Gel Surface to Enable Selective Mono-Ligation to Palladium: Application to Suzuki–Miyaura Cross-Coupling Reactions with Chloroarenes

Immobilized tripods: A silica-supported triarylphosphane (Silica-3p-TPP), containing a Ph3P core immobilized on a silica surface, was synthesized and characterized. Catalysts composed of Pd and Silica-3p-TPP enabled room-temperature Suzuki–Miyaura cross-coupling reactions with unactivated chloroarenes and showed potential in reactions with more challenging substrates (see scheme).

[Full Paper]
Tomohiro Iwai, Ryotaro Tanaka, Tomoya Harada, Masaya Sawamura
Chem. Eur. J. 2014, 20, No. 4, 1057. Read article.

The Effect of Pressure on the Cooperative Spin Transition in the 2D Coordination Polymer {Fe(phpy)2[Ni(CN)4]}

The Effect of Pressure on the Cooperative Spin Transition in the 2D Coordination Polymer {Fe(phpy)2[Ni(CN)4]}

This work demonstrates that the Hofmann-like nonporous two-dimensional polymer {Fe(phpy)2[Ni(CN)4]} can act as a molecular pressure sensor at room temperature.

[Short Communication]
Ana B. Gaspar, Georgiy Levchenko, Sergey Terekhov, Gennadiy Bukin, Javier Valverde-Muñoz, Francisco J. Muñoz-Lara, Maksym Seredyuk, José A. Real
Eur. J. Inorg. Chem. 2014, No. 3, 429. Read article.

Divergent Reactivity of Alkyl Aryl Sulfones with Bases: Selective Functionalization of ortho-Aryl and α-Alkyl Units Enabled by a Unique Carbanion Transmetalation

Divergent Reactivity of Alkyl Aryl Sulfones with Bases: Selective Functionalization of ortho-Aryl and α-Alkyl Units Enabled by a Unique Carbanion Transmetalation

An unusual lithiation selectivity and subsequent transfer of the metal upon warming was observed for various branched alkyl phenyl sulfones. This divergent reactivity was used to prepare substituted aryl sulfones as well as olefins by application of the Julia reaction.

[Full Paper]
Lucie Rehová, Ivana Císarová, Ullrich Jahn
Eur. J. Org. Chem. 2014, No. 7, 1461. Read article.

A Viable Route for Lithium Ion Detection

A Viable Route for Lithium Ion Detection

A monolayer of 5-(4'-pyridylazo)-25,26,27-tris(ethoxycarbonylmethoxy)-28-hydroxycalix[4]arene molecules covalently grafted on quartz substrates provides recognition properties for Li ions at ppm levels in aqueous solutions. The system is fast, reversible, and selective.

[Full Paper]
Antonino Gulino, Fabio Lupo, Domenico A. Cristaldi, Sebastiano Pappalardo, Calogero Capici, Giuseppe Gattuso, Anna Notti, Melchiorre F. Parisi
Eur. J. Inorg. Chem. 2014, No. 3, 442. Read article.

A Route to Cyclooct-2-ynol and Its Functionalization by Mitsunobu Chemistry

A Route to Cyclooct-2-ynol and Its Functionalization by Mitsunobu Chemistry

A new synthesis for cyclooct-2-ynol is presented that does not employ silver salts. The obtained alcohol was further functionalized by Mitsunobu chemistry to afford new cyclooctynes.

[Full Paper]
Tobias Hagendorn, Stefan Bräse
Eur. J. Org. Chem. 2014, No. 6, 1280. Read article.

Structural Basis for Antimicrobial Activity of Lasiocepsin

Structural Basis for Antimicrobial Activity of Lasiocepsin

Membrane penetration: The amphipathic character of lasiocepsin is key for its integration into bacterial membranes. The peptide shows a strong preference for anionic phospholipids, and this is further stimulated by increasing concentrations of cardiolipin at the poles of bacterial cells. Cardiolipin-containing model membranes can be fully penetrated by the peptide.

[Full Paper]
Lenka Monincová, Milos Budešínský, Sabina Čujová, Václav Čerovský, Václav Veverka
ChemBioChem 2014, 15, No. 2, 301. Read article.

Boosting the Resolution of 1H NMR Spectra by Homonuclear Broadband Decoupling

Boosting the Resolution of 1H NMR Spectra by Homonuclear Broadband Decoupling

Unsnarl! An introduction and overview of the techniques and applications of broadband proton-decoupled proton experiments is presented.

[Concept]
N. Helge Meyer, Klaus Zangger
ChemPhysChem 2014, 15, No. 1, 49. Read article.

Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from α,β-Unsaturated Aldehydes

Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from α,β-Unsaturated Aldehydes

Making a splash with citral: The direct one-pot transformation of α,β-unsaturated aldehydes to saturated carboxylic acids using only water proceeds with perfect atom economy. This tandem process involves two redox biotransformations without need of additional external co-substrates for cofactor regeneration. With, for example, citral as prochiral α,β-unsaturated aldehyde, transformation to (S)-citronellic acid proceeds with >99 % conversion and >99 % ee.

[Communication]
Till Winkler, Harald Gröger, Werner Hummel
ChemCatChem 2014, 6, No. 4, 961. Read article.

Effect of the Nature and Location of Copper Species on the Catalytic Nitric Oxide Selective Catalytic Reduction Performance of the Copper/SSZ-13 Zeolite

Effect of the Nature and Location of Copper Species on the Catalytic Nitric Oxide Selective Catalytic Reduction Performance of the Copper/SSZ-13 Zeolite

Copper in uniform: Temperature-programmed reduction of hydrogen and Raman spectroscopy of Cu/SSZ-13 zeolites reveal that copper species are more uniformly speciated in the one-pot synthesized sample (OP; Cu/Al=0.37), which demonstrates higher activity in a wide temperature range than does the ion-exchanged sample (IE; Cu/Al=0.36).

[Full Paper]
Qiang Guo, Fengtao Fan, D. A. J. Michel Ligthart, Guanna Li, Zhaochi Feng, Emiel J. M. Hensen, Can Li
ChemCatChem 2014, 6, No. 2, 634. Read article.

The Synthesis and Biological Evaluation of Multifunctionalised Derivatives of Noscapine as Cytotoxic Agents

The Synthesis and Biological Evaluation of Multifunctionalised Derivatives of Noscapine as Cytotoxic Agents

Yes to noscapine: A series of noscapine derivatives with modifications to the 6', 9', 1 and 7-positions were prepared as potential anticancer agents. The study identified interesting compounds able to induce G2/M cell-cycle arrest and that possess improved cytotoxic activity against the PC3 (prostate), MCF-7 (breast) and PANC-1 (pancreatic) cancer cell lines.

[Full Paper]
Aaron J. DeBono, Sarah J. Mistry, Jinhan Xie, Divya Muthiah, Jackson Phillips, Sabatino Ventura, Richard Callaghan, Colin W. Pouton, Ben Capuano, Peter J. Scammells
ChemMedChem 2014, 9, No. 2, 399. Read article.

Fluorine NMR-Based Screening on Cell Membrane Extracts

Fluorine NMR-Based Screening on Cell Membrane Extracts

Membrane-bound is better: A homogeneous and robust 19F NMR-based functional screening assay on cell extracts was developed for the identification of inhibitors against membrane-bound enzymes and for the determination of their IC50 values. This approach allows the discovery of novel binding fragments against targets known to be difficult to purify or where membrane-association is required for activity.

[Communication]
Marina Veronesi, Elisa Romeo, Chiara Lambruschini, Daniele Piomelli, Tiziano Bandiera, Rita Scarpelli, Gianpiero Garau, Claudio Dalvit
ChemMedChem 2014, 9, No. 2, 286. Read article.

The Effect of Substrates at Cathodes in Low-temperature Fuel Cells

The Effect of Substrates at Cathodes in Low-temperature Fuel Cells

The electrocatalytic activity of platinum-based nanoclusters is affected by their interaction (hybridization) with the support. Ways that lead to a strong interaction with the substrates (carbon-based and oxide-based materials) are discussed.

[Minireview]
Jiwei Ma, Aurélien Habrioux, Nicolas Alonso-Vante
ChemElectroChem 2014, 1, No. 1, 37. Read article.

Optimization of the Probe Coverage in DNA Biosensors by a One-Step Coadsorption Procedure

Optimization of the Probe Coverage in DNA Biosensors by a One-Step Coadsorption Procedure

It's a cover up! The analytical performance of DNA-based biosensors can be easily optimized by adjusting the probe surface coverage through the ionic strength in a one-step coadsorption procedure.

[Article]
Thomas Doneux, Aurore De Rache, Eléonore Triffaux, Anne Meunier, Marc Steichen, Claudine Buess-Herman
ChemElectroChem 2014, 1, No. 1, 147. Read article.

Structure-Dependent Binding of Arylimidamides to the DNA Minor Groove

Structure-Dependent Binding of Arylimidamides to the DNA Minor Groove

Size, charge and polarity: The first detailed study of DNA complexes of modified AIAs shows a surprisingly large variation in DNA interactions with relatively small changes in the structure. Crystallographic analysis of DB1880 bound to an AATT site shows how it fits to the minor groove with big piperidinyl substituents.

[Full Paper]
Yun Chai, Manoj Munde, Arvind Kumar, Leah Mickelson, Sen Lin, Nancy H. Campbell, Moloy Banerjee, Senol Akay, Zongying Liu, Abdelbasset A. Farahat, Raja Nhili, Sabine Depauw, Marie-Hélène David-Cordonnier, Stephen Neidle, W. David Wilson, David W. Boykin
ChemBioChem 2014, 15, No. 1, 68. Read article.

Efficient and Robust Reforming Catalyst in Severe Reaction Conditions by Nanoprecursor Reduction in Confined Space

Efficient and Robust Reforming Catalyst in Severe Reaction Conditions by Nanoprecursor Reduction in Confined Space

A reformed character: The preparation of highly dispersed nickel-containing oxide material allows the design of a highly active and stable nickel reforming catalyst. Control over the size and size distribution of metallic nanoparticles results in improved catalytic activity in the methane dry reforming reaction. These composite materials also exhibit excellent stability under severe reaction conditions.

[Full Paper]
Jean-Philippe Dacquin, Djamila Sellam, Catherine Batiot-Dupeyrat, Asma Tougerti, Daniel Duprez, Sébastien Royer
ChemSusChem 2014, 7, No. 2, 631. Read article.

Engineering the TiO2–Graphene Interface to Enhance Photocatalytic H2 Production

Engineering the TiO2–Graphene Interface to Enhance Photocatalytic H2 Production

Facet to facet: TiO2–graphene nanocomposites with different TiO2 crystal facets ({100}, {101}, and {001} facets) exposed are synthesized to investigate the effects of crystal facet on the photocatalytic properties. The interfacial charge transfer rates and electronic structures of three TiO2–graphene nanocomposites are different, leading to their different photoactivities in photocatalytic H2 production from methanol solution.

[Full Paper]
Lichen Liu, Zhe Liu, Annai Liu, Xianrui Gu, Chengyan Ge, Fei Gao, Lin Dong
ChemSusChem 2014, 7, No. 2, 618. Read article.

Top-Hat and Asymmetric Gaussian-Based Fitting Functions for Quantifying Directional Single-Molecule Motion

Top-Hat and Asymmetric Gaussian-Based Fitting Functions for Quantifying Directional Single-Molecule Motion

Single molecules on the move: Two fitting functions are introduced for measuring in-frame motion of isolated fluorescent emitters. These methods determine the instantaneous directionality and velocity of motion without sacrificing the localization precision. Theory, simulation, and experiments are used to validate the methods, and the fitting algorithms are applied to the motion of live bacteria cells (see picture).

[Article]
David J. Rowland, Julie S. Biteen
ChemPhysChem 2014, 15, No. 4, 712. Read article.

One-Pot Conversion of Carbon Dioxide, Ethylene Oxide, and Amines to 3-Aryl-2-oxazolidinones Catalyzed with Binary Ionic Liquids

One-Pot Conversion of Carbon Dioxide, Ethylene Oxide, and Amines to 3-Aryl-2-oxazolidinones Catalyzed with Binary Ionic Liquids

Hit the pot! An effective one-pot method for the conversion of carbon dioxide, ethylene oxide, and amines to 3-aryl-2-oxazolidinones catalyzed with binary ionic liquids has been developed. This method consists of two parallel reactions and a subsequent cascade reaction between the two products of the corresponding parallel reactions.

[Full Paper]
Binshen Wang, Elnazeer H. M. Elageed, Dawei Zhang, Sijuan Yang, Shi Wu, Guirong Zhang, Guohua Gao
ChemCatChem 2014, 6, No. 1, 278. Read article.

Tailoring Biomass-Derived Carbon Nanoarchitectures for High-Performance Supercapacitors

Tailoring Biomass-Derived Carbon Nanoarchitectures for High-Performance Supercapacitors

Don't throw that away! Biomass-derived carbons with low cost and unique nano-sized architectures are proved to be excellent electrode materials for electrochemical capacitors—a promising class of energy storage devices.

[Concept]
Huanlei Wang, Zhi Li, David Mitlin
ChemElectroChem 2014, 1, No. 2, 332. Read article.

Pyrene–Azobenzene Dyads and Their Photochemistry

Pyrene–Azobenzene Dyads and Their Photochemistry

The facile synthesis and preliminary characterization of three pyrenebutyric acid azobenzene esters (compounds 13) revealed the capacity of the systems to fold, resulting in the modulation of azobenzene photoisomerization through excitation energy transfer from the pyrene chromophore to azobenzene.

[Full Paper]
Olaf Nachtigall, Reiner Lomoth, Christian Dahlstrand, Anna Lundstedt, Adolf Gogoll, Matthew J. Webb, Helena Grennberg
Eur. J. Org. Chem. 2014, No. 5, 966. Read article.

Oxygen Reduction at Soft Interfaces Catalyzed by In Situ-Generated Reduced Graphene Oxide

Oxygen Reduction at Soft Interfaces Catalyzed by In Situ-Generated Reduced Graphene Oxide

Face to face: Flakes of reduced graphene oxide, synthesized in situ at the liquid/liquid interface from a graphene-oxide precursor, are capable of catalyzing the biphasic reduction of protons to hydrogen peroxide in the presence of molecular oxygen and an organic solubilized electron donor. This offers a new perspective for the bulk production of a green oxidant through biphasic electrolysis.

[Communication]
Shokoufeh Rastgar, Haiqiang Deng, Fernando Cortés-Salazar, Micheál D. Scanlon, Medeya Pribil, Véronique Amstutz, Arkady A. Karyakin, Saeed Shahrokhian, Hubert H. Girault
ChemElectroChem 2014, 1, No. 1, 59. Read article.

Kinetic Properties of Carbohydrate–Lectin Interactions: FimH Antagonists

Kinetic Properties of Carbohydrate–Lectin Interactions: FimH Antagonists

Indicators for efficacy: The kinetic properties of carbohydrate–lectin interactions for various FimH antagonists were investigated by surface plasmon resonance. Using the FimH lectin domain in the high-affinity state, surprisingly small dissociation rates were found for the FimH–antagonist complex, resulting in long half-lives in the range of several hours (>3.6 h), which are indictors for high in vivo efficacy.

[Communication]
Meike Scharenberg, Xiaohua Jiang, Lijuan Pang, Giulio Navarra, Said Rabbani, Florian Binder, Oliver Schwardt, Beat Ernst
ChemMedChem 2014, 9, No. 1, 78. Read article.

The Fight against the Influenza A Virus H1N1: Synthesis, Molecular Modeling, and Biological Evaluation of Benzofurazan Derivatives as Viral RNA Polymerase Inhibitors

The Fight against the Influenza A Virus H1N1: Synthesis, Molecular Modeling, and Biological Evaluation of Benzofurazan Derivatives as Viral RNA Polymerase Inhibitors

In the fight against influenza virus A/WSN/33 (H1N1), the PA–PB1 protein–protein interaction is emerging as a new drug target. To identify small molecules able to inhibit the viral RNA polymerase complex, the benzofurazan scaffold was explored by synthesizing a large library of derivatives. Some compounds showed high anti-H1N1 activity and emerged as effective inhibitors of the PA–PB1 interaction, with IC50 values in the micromolar range.

[Full Paper]
Mafalda Pagano, Daniele Castagnolo, Martina Bernardini, Anna Lucia Fallacara, Ilaria Laurenzana, Davide Deodato, Ulrich Kessler, Beatrice Pilger, Lilli Stergiou, Stephan Strunze, Cristina Tintori, Maurizio Botta
ChemMedChem 2014, 9, No. 1, 129. Read article.

Masked Thiol Sugars: Chemical Behavior and Synthetic Applications of S-Glycopyranosyl-N-monoalkyl Dithiocarbamates

Masked Thiol Sugars: Chemical Behavior and Synthetic Applications of S-Glycopyranosyl-N-monoalkyl Dithiocarbamates

Behind the mask: Controlled unmasking of thiolate sugars from S-glycopyranosyl-N-monoalkyl dithiocarbamates is a versatile methodology that allows easy access to diglycosyl disulfides and the S-glycosylation of electrophilic substrates (see scheme).

[Full Paper]
Alicia Megia-Fernandez, Diego de la Torre-Gonzalez, Jose Parada-Aliste, Francisco Javier Lopez-Jaramillo, Fernando Hernandez-Mateo, Francisco Santoyo-Gonzalez
Chem. Asian J. 2014, 9, No. 2, 620. Read article.

Influence of Chromophore Length and Acceptor Groups on the Optical Properties of Rigidified Merocyanine Dyes

Influence of Chromophore Length and Acceptor Groups on the Optical Properties of Rigidified Merocyanine Dyes

Marked and valuable peak shifts in the absorption spectra, as well as quantum yields of up to 95 % were obtained through the systematic experimental and theoretical investigation of rigidified merocyanine dyes. Furthermore, solvatochromism studies in appropriate solvents led to extreme variations in the line shapes (see figure; EWG=electron-withdrawing group).

[Full Paper]
Katharina Christina Kreß, Thomas Fischer, Joachim Stumpe, Wolfgang Frey, Melanie Raith, Omid Beiraghi, S. Holger Eichhorn, Stefan Tussetschläger, Sabine Laschat
ChemPlusChem 2014, 79, No. 2, 223. Read article.

Reduction Mechanism of Fluoroethylene Carbonate for Stable Solid–Electrolyte Interphase Film on Silicon Anode

Reduction Mechanism of Fluoroethylene Carbonate for Stable Solid–Electrolyte Interphase Film on Silicon Anode

To protect and serve: The mechanism by which the electrolyte additive fluoroethylene carbonate (FEC) protects anode materials is proposed. 1) FEC is reduced through the opening of the five-membered ring leading to the formation of lithium poly(vinyl carbonate), LiF, and some dimers; 2) the FEC-derived lithium poly(vinyl carbonate) enhances the stability of the SEI film. The proposed reduction mechanism could help identify new electrolyte additives.

[Full Paper]
Xilin Chen, Xiaolin Li, Donghai Mei, Ju Feng, Mary Y. Hu, Jianzhi Hu, Mark Engelhard, Jianming Zheng, Wu Xu, Jie Xiao, Jun Liu, Ji-Guang Zhang
ChemSusChem 2014, 7, No. 2, 549. Read article.

Molecular and Polymeric Uranyl and Thorium Complexes with Sulfonate-Containing Ligands

Molecular and Polymeric Uranyl and Thorium Complexes with Sulfonate-Containing Ligands

Four sulfonate-containing ligands, some having additional carboxylate groups, were used to synthesize uranyl and thorium(IV) cation complexes, which crystallize as 0D, 1D or 3D assemblies. Monodentate or bridging bidentate sulfonate coordination is observed, and the results show, as phosphonates, that sulfonates have great potential for the synthesis of actinide–organic coordination polymers and frameworks.

[Full Paper]
Pierre Thuéry
Eur. J. Inorg. Chem. 2014, No. 1, 58. Read article.

Kinetic Study of Catalytic Conversion of Cellulose to Sugar Alcohols under Low-Pressure Hydrogen

Kinetic Study of Catalytic Conversion of Cellulose to Sugar Alcohols under Low-Pressure Hydrogen

High in sugar: High-yield production of sugar alcohols (68 %) is demonstrated in the hydrolytic hydrogenation of cellulose over Ru/AC (AC=activated carbon) catalyst under low H2 pressure (<1 MPa) without soluble catalysts and with a mix-milling pretreatment. This pretreatment selectively leads to acceleration of the rate-determining hydrolysis step to maximize the yield of sugar alcohols.

[Full Paper]
Tasuku Komanoya, Hirokazu Kobayashi, Kenji Hara, Wang-Jae Chun, Atsushi Fukuoka
ChemCatChem 2014, 6, No. 1, 230. Read article.

Three Cobalt(II)-Linked {P8W48} Network Assemblies: Syntheses, Structures, and Magnetic and Photocatalysis Properties

Three Cobalt(II)-Linked {P8W48} Network Assemblies: Syntheses, Structures, and Magnetic and Photocatalysis Properties

New connections: A series of cobalt(II)-linked {P8W48} network assemblies have been discovered, one of which contains the largest-ever number of cobalt ions and represents a 3D 12-connected network (see picture). The {P8W48} backbone also shows the highest number of connections. Their magnetic and photocatalysis properties are investigated.

[Full Paper]
Yan-Qing Jiao, Chao Qin, Xin-Long Wang, Chun-Gang Wang, Chun-Yi Sun, Hai-Ning Wang, Kui-Zhan Shao, Zhong-Min Su
Chem. Asian J. 2014, 9, No. 2, 470. Read article.

Highly Selective Dimerization and Trimerization of Isobutene to Linearly Linked Products by Using Nickel Catalysts

Highly Selective Dimerization and Trimerization of Isobutene to Linearly Linked Products by Using Nickel Catalysts

The path less traveled: A promising alternative to the industrially established carbocation oligomerization of isobutene has been found (see figure). Various nickel catalysts were used to generate linearly linked dimers and trimers from isobutene in very high selectivities. The resulting products are potential precursors in the production of plasticizer alcohols. The unique properties of substrate, products, and catalysts permitted interesting mechanistic insights.

[Full Paper]
Arno Behr, Nils Rentmeister, Thomas Seidensticker, Jonas Vosberg, Stephan Peitz, Dietrich Maschmeyer
Chem. Asian J. 2014, 9, No. 2, 596. Read article.

On the Nature of Interactions between Ionic Liquids and Small Amino-Acid-Based Biomolecules

On the Nature of Interactions between Ionic Liquids and Small Amino-Acid-Based Biomolecules

Ionic liquid interactions: This Review gives a comprehensive overview of the current knowledge on the molecular basis and fundamental aspects of the interactions between amino acid-based molecules and ionic liquids, with focus on peptides and miniproteins. Technical (spectroscopy, structural biology) and theoretical (computational chemistry) prerequisites to explain the phenomena reported so far are critically assessed.

[Review]
Alesia A. Tietze, Frank Bordusa, Ralf Giernoth, Diana Imhof, Thomas Lenzer, Astrid Maaß, Carmen Mrestani-Klaus, Ines Neundorf, Kawon Oum, Dirk Reith, Annegret Stark
ChemPhysChem 2013, 14, No. 18, 4044. Read article.

A Hierarchical Nanoporous PtCu Alloy as an Oxygen-Reduction Reaction Electrocatalyst with High Activity and Durability

A Hierarchical Nanoporous PtCu Alloy as an Oxygen-Reduction Reaction Electrocatalyst with High Activity and Durability

A binding agreement: A hierarchical nanoporous PtCu (HNP-PtCu) alloy with a bimodal interconnected network nanostructure was easily fabricated based on a dealloying/annealing/redealloying strategy (see figure). With the specific bimodal nanoporous architecture, HNP-PtCu shows superior electrocatalytic activity towards the oxygen-reduction reaction compared with Pt/C and single NP-PtCu catalysts.

[Full Paper]
Caixia Xu, Huan Zhang, Qin Hao, Huimei Duan
ChemPlusChem 2014, 79, No. 1, 107. Read article.

Oxidative Coupling of 1-Naphthols over Noble and Base Metal Catalysts

Oxidative Coupling of 1-Naphthols over Noble and Base Metal Catalysts

Show your true colors: 1-Naphthols with electron-donating substituents at the ortho or para position couple oxidatively in the presence of hydrogen peroxide and metallic-state catalysts, such as platinum, gold, and nickel to give brightly colored conjugated diones. Yields of up to 99 % can be obtained within 20 minutes under mild reaction conditions (<60 °C and ambient pressure; see scheme).

[Full Paper]
Mabuatsela V. Maphoru, Josef Heveling, Sreejarani K. Pillai
ChemPlusChem 2014, 79, No. 1, 99. Read article.

High-Performance Dye-Sensitized Solar Cells Based on Phenothiazine Dyes Containing Double Anchors and Thiophene Spacers

High-Performance Dye-Sensitized Solar Cells Based on Phenothiazine Dyes Containing Double Anchors and Thiophene Spacers

Anchors aweigh! A series of new push–pull phenothiazine-based dyes featuring various π spacers and double acceptors/anchors have been synthesized, characterized, and used as sensitizers for dye-sensitized solar cells. The best power conversion efficiency of phenothiazine dye is nearly comparable with that of an N719-based standard cell.

[Full Paper]
Wei-I Hung, You-Ya Liao, Chih-Yu Hsu, Hsien-Hsin Chou, Ting-Hui Lee, Wei-Siang Kao, Jiann T. Lin
Chem. Asian J. 2014, 9, No. 1, 357. Read article.

“Clicking” Porphyrins to Magnetic Nanoparticles for Photodynamic Therapy

“Clicking” Porphyrins to Magnetic Nanoparticles for Photodynamic Therapy

Theranostic nanoagents: A porphyrin is “clicked” to a rhodamine-TAT-functionalized superparamagnetic iron oxide nanoparticle (see figure). Upon light irradiation, these nanodevices behave as promising theranostics for achieving the combined action of localizing and tracking drugs through magnetic resonance imaging (MRI)-based techniques and treating cancer cells through photodynamic therapy (PDT).

[Full Paper]
Merlyn Thandu, Valentina Rapozzi, Luigi Xodo, Fernando Albericio, Clara Comuzzi, Silvia Cavalli
ChemPlusChem 2014, 79, No. 1, 90. Read article.

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Non-hinge binding: A novel organometallic protein kinase inhibitor scaffold based on a cyclometalated 1,8-phenanthrolin-7(8 H)-one ligand is reported, which binds to the ATP binding site of the protein kinase Pim1 in an unexpected, unusual non-ATP-mimetic fashion without mimicking the hydrogen-bonding interaction of the adenine nucleobase of ATP.

[Communication]
Kathrin Wähler, Katja Kräling, Holger Steuber, Eric Meggers
ChemistryOpen 2013, 2, No. 5-6, 180. Read article.

Solid-State-Trapped Reactive Ammonium Carbamate Self-Derivative Salts of Prolinamide

Solid-State-Trapped Reactive Ammonium Carbamate Self-Derivative Salts of Prolinamide

Trapped within: We report single-crystal characterization of polymorphs of the ammonium carbamate self-derivative salt of prolinamide, and the first crystal structure of prolinamide and of derived products. This study emphasizes the reactivity of carbonated amines in the solid state and opens perspectives for a systematic study of (solid-state) reactions involving these trapped reactive species.

[Full Paper]
Anaëlle Tilborg, Steve Lanners, Bernadette Norberg, Johan Wouters
ChemistryOpen 2013, 2, No. 5-6, 194. Read article.

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI-MS

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI-MS

Simple and effective: A facile procedure for monitoring chemical reactions and characterizing compounds dissolved in ionic liquids is described using the MS/MS technique. Separation of species of interest was carried out using internal electronic gate available in electrospray mass spectrometers, instead of chromatography and extraction. The separation was carried out as a fast (milliseconds) and sustainable (no extra solvents) procedure.

[Full Paper]
Levon L. Khemchyan, Elena A. Khokhlova, Marina M. Seitkalieva, Valentine P. Ananikov
ChemistryOpen 2013, 2, No. 5-6, 208. Read article.

Metastable β-Bi2O3 Nanoparticles with Potential for Photocatalytic Water Purification Using Visible Light Irradiation

Metastable β-Bi2O3 Nanoparticles with Potential for Photocatalytic Water Purification Using Visible Light Irradiation

Water purification with β-Bi2O3: A straightforward synthetic procedure for the synthesis of β-Bi2O3 nanoparticles that offers the potential for gram-scale production is presented. The β-Bi2O3 nanoparticles show high photocatalytic activity and stability in the degradation of typical organic water pollutants under visible light irradiation. These nanoparticles might be promising materials for use in novel water purification systems.

[Full Paper]
Maik Schlesinger, Marcus Weber, Steffen Schulze, Michael Hietschold, Michael Mehring
ChemistryOpen 2013, 2, No. 4, 146. Read article.