Mission Statement

The Asian Chemical Editorial Society (ACES) is an organization of 13 major chemical societies in Asia and the Pacific. It was founded in 2005 as a conglomeration of chemical societies with the mutual aim of creating a modern publishing forum for research in Asia and coordinating future publishing activities.

The participating societies share a commitment to scientific excellence, to publishing ethics, and to the highest standards in publication, which are the basis for the success of Chemistry—An Asian Journal and its associated journals.

Publications

Chemistry—An Asian Journal

A sister journal of Angewandte Chemie and Chemistry—A European Journal

Supporting Organizations: ChemPubSoc Europe, Gesellschaft Deutscher Chemiker (German Chemical Society, GDCh), Federation of Asian Chemical Societies (FACS).

Asian Journal of Organic Chemistry

A sister journal of the European Journal of Organic Chemistry

For the publication of the AsianJOC, ACES is joined by the Korean Society of Organic Synthesis.

Supporting Organization: ChemPubSoc Europe

ACES supports the publication of the ChemPubSoc Europe journals Chemistry—A European Journal, the European Journal of Organic Chemistry, and ChemSusChem.

© Wiley-VCH 2012

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Chem Asian J

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Asian J Org Chem

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Angew Chem

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Chem Eur J

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Eur J Org Chem

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ChemSusChem

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Chem Rec

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J Chin Chem Soc

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News

Editorials: New Developments

Chemistry - An Asian Journal Theresa Kueckmann
A Good Year
Chem. Asian J. 2014 9, 4.

Asian Journal of Organic ChemistryRichard Threlfall
There's an App for That
Asian J. Org. Chem. 2014 3, 3.

 

Research of the DayEditors' Choice: Spotlights

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Design of Superhydrophobic Porous Coordination Polymers through the Introduction of External Surface Corrugation by the Use of an Aromatic Hydrocarbon Building Unit

Design of Superhydrophobic Porous Coordination Polymers through the Introduction of External Surface Corrugation by the Use of an Aromatic Hydrocarbon Building Unit

A strong aversion to water: In an approach to water-resistant porous materials with a superhydrophobic surface without the use of alkylation or fluorination, a porous coordination polymer was synthesized with a low-symmetry nanoscale organic linker. The material exhibited superhydrophobicity (see picture) as a result of the surface corrugation created by the aromatic hydrocarbon and displayed selective uptake of organic molecules from water.

[Communication]
Koya Prabhakara Rao, Masakazu Higuchi, Kenji Sumida, Shuhei Furukawa, Jingui Duan, Susumu Kitagawa
Angew. Chem. Int. Ed. 2014, 53, No. 31, 8225. Read article.

Chemistry with Graphene and Graphene Oxide—Challenges for Synthetic Chemists

Chemistry with Graphene and Graphene Oxide—Challenges for Synthetic Chemists

The well-controlled synthesis of new graphene and graphene oxide derivatives as well as determination of the atomic structure are key challenges for synthetic chemists. Structure–property relationships must be exploited to use the full potential of graphene derivatives in upcoming applications. This Review focuses on concepts in the chemistry of graphene and graphene oxide with the aim of encouraging chemists to enhance the field of research.

[Review]
Siegfried Eigler, Andreas Hirsch
Angew. Chem. Int. Ed. 2014, 53, No. 30, 7720. Read article.

Chemical Synthesis of the O-Antigen Repeating Unit of Escherichia coli O86 by an N-Formylmorpholine-Modulated One-Pot Glycosylation Strategy

Chemical Synthesis of the O-Antigen Repeating Unit of Escherichia coli O86 by an N-Formylmorpholine-Modulated One-Pot Glycosylation Strategy

O, I say! An N-formylmorpholine (NFM)-modulated one-pot glycosylation was used for the synthesis for construction of 1,2-cis α-glycosidic linkages in the synthesis of the pentasaccharide repeating unit of the O-antigen that is found in Escherichia coli O86.

[Full Paper]
Arun B. Ingle, Chin-Sheng Chao, Wei-Cheng Hung, Kwok-Kong Tony Mong
Asian J. Org. Chem. 2014, 3, No. 8, 870. Read article.

Macrocyclic Protease Inhibitors with Reduced Peptide Character

Macrocyclic Protease Inhibitors with Reduced Peptide Character

The incorporation of a pyrrole into a peptide backbone generates simple macrocycles that adopt a β-strand geometry. The attachment of a P1 amino aldehyde to these templates then gives rise to potent protease inhibitors (see example, top, which has Ki values of 440 pM and 920 pM against the cysteine cathepsins L and S, respectively). A crystal structure of a related derivative bound to chymotrypsin (see picture, bottom) confirms the design.

[Communication]
Krystle C. H. Chua, Markus Pietsch, Xiaozhou Zhang, Stephanie Hautmann, Hon Y. Chan, John B. Bruning, Michael Gütschow, Andrew D. Abell
Angew. Chem. Int. Ed. 2014, 53, No. 30, 7828. Read article.

A Metallic Room-Temperature Oxide Ion Conductor

A Metallic Room-Temperature Oxide Ion Conductor

Oxygen topochemistry: Nanoparticles of Bi3Ir, a hitherto uncharacterized intermetallic compound, reversibly intercalate oxygen from air at room temperature. In the resulting metallic suboxide, the intermetallic building units are preserved. The activation energy for oxide diffusion is one order of magnitude smaller than that in any known material. Bi3IrOx is the first metallic oxide ion conductor and also the first that operates at room temperature.

[Communication]
Martin Heise, Bertold Rasche, Anna Isaeva, Alexey I. Baranov, Michael Ruck, Konrad Schäfer, Rainer Pöttgen, Jens-Peter Eufinger, Jürgen Janek
Angew. Chem. Int. Ed. 2014, 53, No. 28, 7344. Read article.

Direct Metal-Catalyzed Regioselective Functionalization of Enamides

Direct Metal-Catalyzed Regioselective Functionalization of Enamides

Useful nitrogen-containing heterocycles can be rapidly synthesized from metal-catalyzed regioselective functionalization of enamides. This review discloses the progress made in the development of the direct C-H functionalization of enamides involving efficient and atom-economical routes (see scheme; EWG=electron-withdrawing group).

[Review]
Nicolas Gigant, Laëtitia Chausset-Boissarie, Isabelle Gillaizeau
Chem. Eur. J. 2014, 20, No. 25, 7548. Read article.

Combining the Diaza-Diels–Alder Reaction and Palladium-Catalyzed Aminations to Prepare Amino-Substituted Porphyrins

Combining the Diaza-Diels–Alder Reaction and Palladium-Catalyzed Aminations to Prepare Amino-Substituted Porphyrins

Who's the DADA? The diaza-Diels–Alder (DADA) reaction was combined with palladium-catalyzed amination of bromoporphyrins to generate aminated porphyrins. The X-ray crystal structure of an anthracene-derived aminoporphyrin nickel(II) complex confirms the sequence.

[Full Paper]
Mean See Goh, Michael C. Pfrunder, John C. McMurtrie, Dennis P. Arnold
Asian J. Org. Chem. 2014, 3, No. 8, 856. Read article.

Aminomethylenehelicene Oligomers Possessing Flexible Two-Atom Linker Form a Stimuli-Responsive Double-Helix in Solution

Aminomethylenehelicene Oligomers Possessing Flexible Two-Atom Linker Form a Stimuli-Responsive Double-Helix in Solution

Getting your oligomers in a twist: Aminomethylenehelicene oligomers up to the heptamer were synthesized by reductive amination reactions, and the oligomers containing more than three helicenes formed double helices. The oligomers unfold and fold in response to heating and cooling, accompanied by a two-sided thermal hysteresis. Structural changes within the oligomers are also reversible by treatment with acid or base.

[Full Paper]
Masanori Shigeno, Masahiko Sato, Yo Kushida, Masahiko Yamaguchi
Asian J. Org. Chem. 2014, 3, No. 7, 797. Read article.

Modified SWCNTs with Amphoteric Redox and Solubilizing Properties

Modified SWCNTs with Amphoteric Redox and Solubilizing Properties

Dual functions: The incorporation of two different functional groups, a tetracyanoanthra-para-quinodimethane (TCAQ) unit and an imidazolium-based ionic liquid, on single-wall carbon nanotubes (SWCNTs; see the picture) creates a potential electroactive material with tunable hydrophilic/hydrophobic polarity by simple ion exchange. The functional group position was interchanged and further studied to evaluate its influence.

[Full Paper]
Laura Rodríguez-Pérez, Raúl García, María Angeles Herranz, Nazario Martín
Chem. Eur. J. 2014, 20, No. 24, 7278. Read article.

Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals

Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals

New Sc3+ carrier delivers: Complexes of trivalent scandium with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA) were investigated in solution and in the solid state. Potentiometry and multinuclear NMR spectrometry revealed relatively fast complexation of Sc3+ with DOTA, as well as very high stability constants and high kinetic inertness for the complex. The data confirmed that DOTA-like ligands are very suitable for the development of scandium-based radiopharmaceuticals (see figure).

[Full Paper]
Miroslav Pniok, Vojtech Kubíček, Jana Havlíčková, Jan Kotek, Andrea Sabatie-Gogová, Jan Plutnar, Sandrine Huclier-Markai, Petr Hermann
Chem. Eur. J. 2014, 20, No. 26, 7944. Read article.

Recent Advances in the Synthesis of Carbocyclic Nucleosides via Ring-Closing Metathesis

Recent Advances in the Synthesis of Carbocyclic Nucleosides via Ring-Closing Metathesis

R.C.M.: The structure and biological activity of five-membered carbocyclic nucleosides have motivated chemists over the last several decades to synthesize these compounds. Ring-closing metathesis (RCM) has evolved as an effective tool for making these deceptively simple molecules. The impact of RCM culminated in several strategies for the synthesis of nucleoside analogues from carbohydrates or chiral auxiliaries. Bn=benzyl; TBDPS=tert-butyldiphenylsilyl; Tr=trityl.

[Focus Review]
Varughese A. Mulamoottil, Akshata Nayak, Lak Shin Jeong
Asian J. Org. Chem. 2014, 3, No. 7, 748. Read article.

Ligand-Assisted Dual-Site Click Labeling of EGFR on Living Cells

Ligand-Assisted Dual-Site Click Labeling of EGFR on Living Cells

Dual-site click labeling: A ligand-assisted CuAAC reaction, pyrrolysine-based genetic code expansion strategy, and the PRIME labeling technique were integrated for dual-site click labeling of EGFR at the surface of mammalian cells. This strategy enabled simultaneous installation of a FRET donor–acceptor pair onto the extracellular domains of EGFR, thereby allowing cis-membrane FRET imaging of receptor dynamics.

[Communication]
Yi Yang, Shixian Lin, Wei Lin, Peng R. Chen
ChemBioChem 2014, 15, No. 12, 1738. Read article.

New Polydentate Trimethylsilyl Chalcogenide Reagents for the Assembly of Polyferrocenyl Architectures

New Polydentate Trimethylsilyl Chalcogenide Reagents for the Assembly of Polyferrocenyl Architectures

Bond after bond: A series of polychalcogenotrimethylsilane complexes Ar(CH2ESiMe3)n (Ar=aryl; E=S, Se; n=2, 3, and 4) have been prepared that incorporate a large number of reactive -ESiMe3 moieties onto an organic molecular framework (see figure). They are shown to be convenient reagents for the preparation of the polyferrocenylseleno- and thioesters from ferrocenoyl chloride.

[Full Paper]
Mahmood Azizpoor Fard, Bahareh Khalili Najafabadi, Mahdi Hesari, Mark S. Workentin, John F. Corrigan
Chem. Eur. J. 2014, 20, No. 23, 7037. Read article.

Controlling Helix Handedness in Water-Soluble Quinoline Oligoamide Foldamers

Controlling Helix Handedness in Water-Soluble Quinoline Oligoamide Foldamers

The control of the helix handedness of water-soluble quinoline-based oligoamide foldamers has been investigated by the installation of chiral end groups at either the N or C terminus. This has respectively afforded either quantitative induction of handedness or the ability to separate kinetically locked P and M helices as diastereoisomers.

[Full Paper]
Simon J. Dawson, Adám Mészáros, Lilla Pethő, Cinzia Colombo, Márton Csékei, András Kotschy, Ivan Huc
Eur. J. Org. Chem. 2014, No. 20, 4265. Read article.

Dinuclear Platinum Complexes Containing Planar Aromatic Ligands to Enhance Stacking Interactions with Proteins

Dinuclear Platinum Complexes Containing Planar Aromatic Ligands to Enhance Stacking Interactions with Proteins

The life of π: Pt-based quinoline and benzothiazole complexes were synthesized with an aim to design drugs with higher affinity for π–π stacking and electrostatic interactions with targeted biomolecules. Fluorescence spectroscopy and molecular modeling led to candidate complexes with significant cytotoxicity toward various tumor cell lines.

[Full Paper]
Erin S. F. Ma, A. Gerard Daniel, Nicholas P. Farrell
ChemMedChem 2014, 9, No. 6, 1155. Read article.

Competing Reactions of CO2 with Cations and Anions in Azolide Ionic Liquids

Competing Reactions of CO2 with Cations and Anions in Azolide Ionic Liquids

Two different paths: Phosphonium azolide ionic liquids of interest for CO2 capture applications react with CO2 both through the normal anion channel and, at elevated temperatures, through a previously unrecognized cation channel. The cation channel involves a phosphonium ylide intermediate that is formed due to cation/anion interactions. This channel is suppressed with less-acidic ammonium cations.

[Full Paper]
Thomas R. Gohndrone, Tae Bum Lee, M. Aruni DeSilva, Mauricio Quiroz-Guzman, William F. Schneider, Joan F. Brennecke
ChemSusChem 2014, 7, No. 7, 1970. Read article.

Br�nsted Acid Ionic Liquid as a Solvent-Conserving Catalyst for Organic Reactions

Brønsted Acid Ionic Liquid as a Solvent-Conserving Catalyst for Organic Reactions

Brains not Brønsted: Sulfonyl-containing ammonium-based Brønsted acid ionic liquids (ILs) are prepared and used as liquid heterogeneous catalysts for organic reactions under solvent-free conditions. The sulfonyl group endowed these ILs with unique macroscopic phase heterogeneity in the reaction system, ensuring outstanding catalytic activities of the ILs. These catalytic systems are applicable in a wide range of acid-catalyzed reactions.

[Communication]
Amir Taheri, Xiaojuan Pan, Changhui Liu, Yanlong Gu
ChemSusChem 2014, 7, No. 8, 2094. Read article.

Resveratrol and Its Metabolites Bind to PPARs

Resveratrol and Its Metabolites Bind to PPARs

More red wine, please: Resveratrol, a signaling protein modulator, can exert off-target effects involving peroxisome proliferator-activated receptors (PPARs). Results from chromatographic and isothermal titration calorimetry experiments indicate that resveratrol and its metabolites bind PPARγ directly, but only resveratrol interacts with PPARα, thus suggesting a new pattern of receptor–ligand recognition.

[Full Paper]
Enrica Calleri, Giorgio Pochetti, Katina S. S. Dossou, Antonio Laghezza, Roberta Montanari, Davide Capelli, Ellen Prada, Fulvio Loiodice, Gabriella Massolini, Michel Bernier, Ruin Moaddel
ChemBioChem 2014, 15, No. 8, 1154. Read article.

Derivatization of Antibody Fab Fragments: A Designer Enzyme for Native Protein Modification

Derivatization of Antibody Fab Fragments: A Designer Enzyme for Native Protein Modification

Trypsin in reverse: Trypsiligase (trypsin K60E/N143H/E151H/D189K) was used for highly selective PEGylation of the anti-Her2 Fab fragment under native conditions. The approach resulted in a fully functional antibody fragment with good product yield.

[Communication]
Sandra Liebscher, Petra Kornberger, Gerhard Fink, Eva-Maria Trost-Gross, Eva Höss, Arne Skerra, Frank Bordusa
ChemBioChem 2014, 15, No. 8, 1096. Read article.

Design and Synthesis of a Monofluoro-Substituted Aromatic Amino Acid as a Conformationally Restricted 19F NMR Label for Membrane-Bound Peptides

Design and Synthesis of a Monofluoro-Substituted Aromatic Amino Acid as a Conformationally Restricted 19F NMR Label for Membrane-Bound Peptides

A monofluoro-substituted cyclobutane-derived amino acid was designed and synthesized as a 19F label for studying membrane-bound peptides by solid-state 19F NMR spectroscopy. This amino acid can be safely used to replace aromatic proteinogenic amino acids (Phe, Tyr) within α-helices and β-turns. This was demonstrated experimentally in the cyclic gramicidin S, as well as by molecular modeling.

[Full Paper]
Anton N. Tkachenko, Pavel K. Mykhailiuk, Dmytro S. Radchenko, Oleg Babii, Sergii Afonin, Anne S. Ulrich, Igor V. Komarov
Eur. J. Org. Chem. 2014, No. 17, 3584. Read article.

Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component

Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component

The enantiospecific synthesis and biological activities of a nuphar alkaloid have been described. Reliable and scalable chemistry was used to synthesize the alkaloid in nine steps, and an affinity to three central nervous system (CNS) receptors, including the oxytocin receptor, was found.

[Full Paper]
Hajime Seki, Gunda I. Georg
Eur. J. Org. Chem. 2014, No. 18, 3777. Read article.

Generation of Basic Centers in High-Silica Zeolites and their Application in Gas-Phase Upgrading of Bio-Oil

Generation of Basic Centers in High-Silica Zeolites and their Application in Gas-Phase Upgrading of Bio-Oil

Creating new basic sites: Through activation treatments in alkaline media, basic sites with high activity, stability, and selectivity are generated in high-silica FAU, BEA, and MFI zeolites, which enable the efficient deoxygenation of pyrolysis oil by condensation reactions. Intermediate bio-oil upgrading is key for the sustainable and profitable production of advanced biofuels.

[Full Paper]
Tobias C. Keller, Elodie G. Rodrigues, Javier Pérez-Ramírez
ChemSusChem 2014, 7, No. 6, 1729. Read article.

Palladium and Gold Nanotubes as Oxygen Reduction Reaction and Alcohol Oxidation Reaction Catalysts in Base

Palladium and Gold Nanotubes as Oxygen Reduction Reaction and Alcohol Oxidation Reaction Catalysts in Base

Pd ORR Au: Palladium nanotubes (PdNTs) and gold nanotubes (AuNTs) are studied as oxygen reduction reaction (ORR) and alcohol oxidation reaction catalysts in base. PdNTs and AuNTs produce ORR area activities that are 2.9 and 2.3 times greater than those produced by Pd/C and Au/C, respectively. The PdNTs further show improved methanol, ethanol, and ethylene glycol oxidation activity in comparison to nanoparticle catalysts.

[Full Paper]
Shaun M. Alia, Kathlynne Duong, Toby Liu, Kurt Jensen, Yushan Yan
ChemSusChem 2014, 7, No. 6, 1739. Read article.

Insight into the Recognition, Binding, and Reactivity of Catalytic Metallodrugs Targeting Stem Loop IIb of Hepatitis C IRES RNA

Insight into the Recognition, Binding, and Reactivity of Catalytic Metallodrugs Targeting Stem Loop IIb of Hepatitis C IRES RNA

Metal with mettle: Catalytic metallodrugs are a new compound class with potential for high therapeutic activity and low toxicity. The Cu-GGHYrFK-amide complex was reported earlier to catalytically inactivate stem loop IIb of the HCV internal ribosomal entry site RNA, and to show significant antiviral activity in a cellular HCV replicon assay. Herein we describe our studies focused on understanding the cleavage mechanism and the relationship of catalyst configuration to structural recognition and site-selective cleavage of the structured RNA motif.

[Full Paper]
Seth S. Bradford, Martin James Ross, Insiya Fidai, James A. Cowan
ChemMedChem 2014, 9, No. 6, 1275. Read article.

Straightforward Access to Hexahydropyrrolo[2,3-b]indole Core by a Regioselective C3-Azo Coupling Reaction of Arenediazonium Compounds with Tryptamines

Straightforward Access to Hexahydropyrrolo[2,3-b]indole Core by a Regioselective C3-Azo Coupling Reaction of Arenediazonium Compounds with Tryptamines

A new method for construction of the pyrroloindoline framework by way of arenediazonium-triggered cyclization of tryptamines allows for direct and efficient access to a synthetically important structural motif. The reaction is the first example of diazonium-induced 1,2-diamination.

[Full Paper]
David E. Stephens, Oleg V. Larionov
Eur. J. Org. Chem. 2014, No. 17, 3662. Read article.

Structural Basis of Furan–Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells

Structural Basis of Furan–Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells

Photo opportunity: We report the genetic encoding of a furan-based, photo-crosslinking amino acid in human cells by a mutant pyrrolysyl-tRNA synthetase (PylRS) with broad polyspecificity. Crystal structures of this enzyme reveal the mode of furan amino acid recognition and the basis of polyspecificity, thus providing a promising starting point for engineering PylRS mutants with increased substrate scope.

[Communication]
Moritz J. Schmidt, Annemarie Weber, Moritz Pott, Wolfram Welte, Daniel Summerer
ChemBioChem 2014, 15, No. 12, 1755. Read article.

SnS2 Nanoplatelet@Graphene Nanocomposites as High-Capacity Anode Materials for Sodium-Ion Batteries

SnS2 Nanoplatelet@Graphene Nanocomposites as High-Capacity Anode Materials for Sodium-Ion Batteries

Just tin time! SnS2 nanoplatelets were incorporated with graphene by using a facile hydrothermal method. Graphene nanosheets act as a heterogeneous dispersing agent to prevent the aggregation of SnS2 nanoplatelets and provide electrically conductive networks, which lead to an improved electrochemical performance for sodium-ion storage (see figure).

[Full Paper]
Xiuqiang Xie, Dawei Su, Shuangqiang Chen, Jinqiang Zhang, Shixue Dou, Guoxiu Wang
Chem. Asian J. 2014, 9, No. 6, 1611. Read article.

N-Heterocyclic Carbene-Catalyzed Enantioselective Annulation of Indolin-3-ones with Bromoenals

N-Heterocyclic Carbene-Catalyzed Enantioselective Annulation of Indolin-3-ones with Bromoenals

More NHC-organocatalysis: N-Heterocyclic carbene-catalyzed reactions of indolin-3-ones with 2-bromoenals opened an asymmetric access to 3,4-dihydropyrano[3,2-b]indol-2(5 H)-ones in good yields and with good to excellent enantioselectivities. This protocol tolerates a broad substrate scope. In addition, a possible mechanism for the annulation reaction is presented.

[Communication]
Qijian Ni, Xiaoxiao Song, Gerhard Raabe, Dieter Enders
Chem. Asian J. 2014, 9, No. 6, 1535. Read article.

Nerve Agent Degradation with Polyoxoniobates

Nerve Agent Degradation with Polyoxoniobates

Polyoxometalates, like small pieces of metal oxide, can be dissolved or fixed on a surface to perform homogeneous or heterogeneous catalysis, respectively. Here we exploit the alkaline nature of polyoxoniobates to neutralize nerve agents in both solution and the solid state. Solution studies correlate reaction efficacy to the association of the dissolved polyoxoniobate with its counterions.

[Full Paper]
Mark K. Kinnan, William R. Creasy, Lauren B. Fullmer, Heidi L. Schreuder-Gibson, May Nyman
Eur. J. Inorg. Chem. 2014, No. 14, 2361. Read article.

Discovery of 14-3-3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

Discovery of 14-3-3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

Pièce de résistance! Multidrug resistance (MDR) is the main obstacle toward effective anticancer therapy. Herein we report the discovery of two small-molecule 14-3-3 protein–protein interaction inhibitors that promote the translocation of c-Abl and FOXO pro-apoptotic factors into the nucleus and sensitize MDR cancer cells to doxorubicin and the pan-Akt inhibitor GSK690693.

[Full Paper]
Mattia Mori, Giulia Vignaroli, Ylenia Cau, Jelena Dinić, Richard Hill, Matteo Rossi, David Colecchia, Milica Pešić, Wolfgang Link, Mario Chiariello, Christian Ottmann, Maurizio Botta
ChemMedChem 2014, 9, No. 5, 973. Read article.

A Glimpse into the Molecular Journey inside an Ultralow Sulfur Diesel Reactor

A Glimpse into the Molecular Journey inside an Ultralow Sulfur Diesel Reactor

Keeping on the ultralow: Quantitative information about the journey of sulfur molecules inside an operating ultralow sulfur diesel reactor is provided. This information coupled with other new insights obtained under realistic industrial conditions is expected to significantly increase the effectiveness of future studies aimed at increasing the efficiency of the ultralow sulfur diesel process. ppmw=parts per million by weight

[Full Paper]
Tushar V. Choudhary, Kening Gong, Phillipp Ellison, Ayyappan Subbiah
ChemCatChem 2014, 6, No. 6, 1782. Read article.

MnO2 Nanoflower Arrays with High Rate Capability for Flexible Supercapacitors

MnO2 Nanoflower Arrays with High Rate Capability for Flexible Supercapacitors

Great things in small packages: Large-area α-MnO2 nanoflower arrays on flexible substrates are synthesized through a facial template-free electrochemical deposition process. These nanoflower arrays produce an enhanced electrochemical performance in the form of a high specific capacitance with remarkable rate capability and excellent cycling stability.

[Communication]
Wenyao Li, Kaibing Xu, Bo Li, Jianqing Sun, Feiran Jiang, Zhishui Yu, Rujia Zou, Zhigang Chen, Junqing Hu
ChemElectroChem 2014, 1, No. 6, 1003. Read article.

The Nematic Phases of Bent-Core Liquid Crystals

The Nematic Phases of Bent-Core Liquid Crystals

Bent on stability: The nematic liquid-crystal phases formed by bent-core molecules have remarkable properties. This Minireview reports recent progress in stabilizing the nematic phase at accessible temperatures, concentrating on oxadiazole-based materials. It also describes recent measurements of their physical properties, including optical, dielectric, elastic, and flexoelectric coefficients, and electric field effects (see graphic).

[Minireview]
Helen F. Gleeson, Sarabjot Kaur, Verena Görtz, Abdel Belaissaoui, Stephen Cowling, John W. Goodby
ChemPhysChem 2014, 15, No. 7, 1251. Read article.

Structural Optimization of Interpenetrated Pillared-Layer Coordination Polymers for Ethylene/Ethane Separation

Structural Optimization of Interpenetrated Pillared-Layer Coordination Polymers for Ethylene/Ethane Separation

Separation is never easy: With the goal of achieving effective ethylene/ethane separation, we evaluated the gas sorption properties of four flexible pillared-layer-type porous coordination polymers (PCPs) with double interpenetration. Among these compounds, a PCP containing the narrowest pores exhibits ethylene-selective sorption property at ambient temperature and pressure, as examined by breakthrough experiments with ethylene/ethane gas mixtures.

[Full Paper]
Keisuke Kishida, Satoshi Horike, Yoshihiro Watanabe, Mina Tahara, Yasutaka Inubushi, Susumu Kitagawa
Chem. Asian J. 2014, 9, No. 6, 1643. Read article.

Visible-Light-Driven Water Oxidation with Nanoscale Co3O4: New Optimization Strategies

Visible-Light-Driven Water Oxidation with Nanoscale Co3O4: New Optimization Strategies

Study history, study history: Visible-light-driven Co3O4 spinel water oxidation catalysts (WOCs) were hydrothermally prepared and investigated with respect to the influence of preparative history on the catalytic activity. We present a counterintuitive design trend: crystallinity and valence states are more important for WOC performance than surface area. New “top down” and “bottom up” strategies for Co3O4 WOC optimization are proposed.

[Full Paper]
Hongfei Liu, Greta R. Patzke
Chem. Asian J. 2014, 9, No. 8, 2249. Read article.

Thermal Expansion, Anharmonicity and Temperature-Dependent Raman Spectra of Single- and Few-Layer MoSe2 and WSe2

Thermal Expansion, Anharmonicity and Temperature-Dependent Raman Spectra of Single- and Few-Layer MoSe2 and WSe2

Special effects in 2D: The temperature-dependent Raman spectra of single- and few-layer MoSe2 and WSe2 in the 77–700 K range are reported. Linear variation is observed in the peak positions and widths of the bands arising from contributions of anharmonicity and thermal expansion.

[Article]
Dattatray J. Late, Sharmila N. Shirodkar, Umesh V. Waghmare, Vinayak P. Dravid, C. N. R. Rao
ChemPhysChem 2014, 15, No. 8, 1592. Read article.

De Novo Designed Copper α-Helical Peptides: From Design to Function

De Novo Designed Copper α-Helical Peptides: From Design to Function

De novo designed α-helical peptides have been used to design structural and functional copper sites in minimum protein scaffolds. The design of structural copper Type 1, Type 2, Type A, and Cu–SCys centers in α-helical constructs is described. Catalytic copper Type 2 centers are also presented, along with their functional features.

[Microreview]
Matteo Tegoni
Eur. J. Inorg. Chem. 2014, No. 13, 2177. Read article.

Heterogeneous Catalysis of Multiple-Electron-Transfer Reactions at Nanoparticle-Modified Electrodes

Heterogeneous Catalysis of Multiple-Electron-Transfer Reactions at Nanoparticle-Modified Electrodes

Control freak: The final product of important multistep electrode reactions, such as the electro-reduction of oxygen, depends on the extent of a surface-catalysed reaction and, therefore, on the nature and coverage of the nanoparticles employed for the electrode modification.

[Article]
Eduardo Laborda, Christopher C. M. Neumann, Ying Wang, Kristopher R. Ward, Angela Molina, Richard G. Compton
ChemElectroChem 2014, 1, No. 5, 909. Read article.

Shielding of a Microdisc Electrode Surrounded by an Adsorbing Surface

Shielding of a Microdisc Electrode Surrounded by an Adsorbing Surface

Sheath shielding: It is shown that if significant adsorption occurs on the sheath used to insulate a microdisc electrode, then it can have a high impact on the measured current–time data because of a considerable shielding effect. Chronoamperograms are simulated as a function of the sheath-to-disc electrode radius ratio and the rate constant for adsorption onto the sheath.

[Article]
Shaltiel Eloul, Richard G. Compton
ChemElectroChem 2014, 1, No. 5, 917. Read article.

Cytotoxic Gold(I) N-heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors

Cytotoxic Gold(I) N-heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors

Gold renaissance! Gold(I) N-heterocyclic carbene complexes with phosphane ligands effectively inhibit the the seleno-enzyme thioredoxin reductase (TrxR) and the zinc-finger enzyme poly(ADP-ribose) polymerase 1 (PARP-1) and trigger potent cytotoxicity in cancer cells.

[Full Paper]
Riccardo Rubbiani, Luca Salassa, Andreia de Almeida, Angela Casini, Ingo Ott
ChemMedChem 2014, 9, No. 6, 1205. Read article.

Macroscopic Control of Helix Orientation in Films Dried from Cholesteric Liquid-Crystalline Cellulose Nanocrystal Suspensions

Macroscopic Control of Helix Orientation in Films Dried from Cholesteric Liquid-Crystalline Cellulose Nanocrystal Suspensions

Film star: A new method for drying cholesteric liquid-crystalline cellulose nanocrystal suspensions into solid films avoids phase coexistence and, with an applied circular shear flow, yields unprecedented structural control. The commonly observed mosaic-like structure, with randomly varying orientation of the cholesteric helix axis, is replaced by a macroscopically uniform film with improved optical properties (see figure).

[Article]
Ji Hyun Park, JungHyun Noh, Christina Schütz, German Salazar-Alvarez, Giusy Scalia, Lennart Bergström, Jan P. F. Lagerwall
ChemPhysChem 2014, 15, No. 7, 1477. Read article.

Sample Preparation of Energy Materials for X-ray Nanotomography with Micromanipulation

Sample Preparation of Energy Materials for X-ray Nanotomography with Micromanipulation

It's all in the prep: Novel sample preparation for X-ray nanotomography by using focused-ion-beam (FIB) and micromanipulation ensures high-quality data. The proposed procedure resolves the issues that cause the view of the sample base to be blocked after FIB milling and during the lift-out process. This method enables the broad application of X-ray nanotomography in microstructure studies.

[Article]
Yu-chen Karen Chen-Wiegart, Fernando E. Camino, Jun Wang
ChemPhysChem 2014, 15, No. 8, 1587. Read article.

Characterization of a Fluidized Catalytic Cracking Catalyst on Ensemble and Individual Particle Level by X-ray Micro- and Nanotomography, Micro-X-ray Fluorescence, and Micro-X-ray Diffraction

Characterization of a Fluidized Catalytic Cracking Catalyst on Ensemble and Individual Particle Level by X-ray Micro- and Nanotomography, Micro-X-ray Fluorescence, and Micro-X-ray Diffraction

Mini techniques, bigger picture: A combination of advanced characterization techniques, synchrotron X-ray micro- and nanotomography, micro-X-ray fluorescence, and micro-XRD, are used to characterize a commercial spent equilibrium fluid catalytic cracking catalyst at both the ensemble and individual particle level.

[Full Paper]
Simon R. Bare, Meghan E. Charochak, Shelly D. Kelly, Barry Lai, Jun Wang, Yu-chen Karen Chen-Wiegart
ChemCatChem 2014, 6, No. 5, 1427. Read article.

Insights into the Organocatalyzed Synthesis of Urethanes in Supercritical Carbon Dioxide: An In Situ FTIR Spectroscopic Kinetic Study

Insights into the Organocatalyzed Synthesis of Urethanes in Supercritical Carbon Dioxide: An In Situ FTIR Spectroscopic Kinetic Study

Back to the FTIR: The most efficient organocatalysts have been identified for the reaction of alcohols with isocyanates in supercritical CO2 in a step towards a green process for polyurethane synthesis. The order of activity of the catalysts in supercritical CO2 does not always follow that observed in conventional media.

[Full Paper]
Christopher A. Smith, Henri Cramail, Thierry Tassaing
ChemCatChem 2014, 6, No. 5, 1380. Read article.

Facile Synthesis of Carbon-Encapsulated Li4Ti5O12@C Hollow Microspheres as Superior Anode Materials for Li-Ion Batteries

Facile Synthesis of Carbon-Encapsulated Li4Ti5O12@C Hollow Microspheres as Superior Anode Materials for Li-Ion Batteries

A solution-phase self-assembly and solid-phase carbonization route for the synthesis of uniform hollow carbon microspheres embedded with Li4Ti5O12 nanoparticles has been developed. The microsized spherical Li4Ti5O12@C hollow composites have conductive carbon shells, which endow them with high specific capacity, rate capability, electrode density, and cycle stability.

[Full Paper]
Jun Liu, Wei Liu, Shaomin Ji, Yanling Wan, Huaqi Yin, Yichun Zhou
Eur. J. Inorg. Chem. 2014, No. 12, 2073. Read article.

Kinetic Evidence of Tautomerism of Thiourea Dioxide in Aqueous Acidic Solutions

Kinetic Evidence of Tautomerism of Thiourea Dioxide in Aqueous Acidic Solutions

Kinetic evidence of the tautomerism of thiourea dioxide in aqueous acidic solutions is reported. The reactivity of the two tautomeric forms towards ClO2 significantly differs in rate and also in mechanistic aspects. Whereas aminoiminomethanesulfinic acid reacts with ClO2 in a second-order process, the reaction of its tautomeric form, thiourea dioxide, with ClO2 displays autocatalysis.

[Short Communication]
György Csekő, Ying Hu, Yanan Song, Tímea R. Kégl, Qingyu Gao, Sergei V. Makarov, Attila K. Horváth
Eur. J. Inorg. Chem. 2014, No. 11, 1875. Read article.

Role of the Base and Control of Selectivity in the Suzuki–Miyaura Cross-Coupling Reaction

Role of the Base and Control of Selectivity in the Suzuki–Miyaura Cross-Coupling Reaction

Follow the organoborate road: Competition Suzuki–Miyaura reactions between two boronic acids with different pKa values reveal the link between acid–base chemistry and the reaction catalytic cycle. The results reveal that the borate path is the preferred route for transmetalation and thus confirm the role of the base in the reaction mechanism.

[Full Paper]
Carlos F. R. A. C. Lima, Ana S. M. C. Rodrigues, Vera L. M. Silva, Artur M. S. Silva, Luís M. N. B. F. Santos
ChemCatChem 2014, 6, No. 5, 1291. Read article.

Oxygen-Terminated Diamond Electrodes in Alkaline Media: Structure and OH Generation

Oxygen-Terminated Diamond Electrodes in Alkaline Media: Structure and OH Generation

Not only a girl's best friend: Boron-doped diamond is important as an electrode material. Oxygen-terminated diamonds and the kinetics of OH generation in alkaline solutions on this type of surface are studied theoretically; this allows detailed structure and energetics characterization of the systems, as well as an understanding of the reaction dynamics that proceed in an outer-sphere mode.

[Article]
Paola M. Quaino, Wolfgang Schmickler
ChemElectroChem 2014, 1, No. 5, 933. Read article.

Water-Soluble Pillararene-Functionalized Graphene Oxide for In Vitro Raman and Fluorescence Dual-Mode Imaging

Water-Soluble Pillararene-Functionalized Graphene Oxide for In Vitro Raman and Fluorescence Dual-Mode Imaging

Paving the way: The successful preparation of biocompatible hybrids by integrating graphene oxide with amphiphilic pillararenes for in vitro Raman and fluorescence dual-mode bioimaging has been carried out (see scheme), thereby paving the way for utilizing these materials in combined cancer diagnostics.

[Full Paper]
Huacheng Zhang, Xing Ma, Kim Truc Nguyen, Yongfei Zeng, Shuhui Tai, Yanli Zhao
ChemPlusChem 2014, 79, No. 3, 462. Read article.

Fabrication of Reduced Graphene Oxide (RGO)/Co3O4 Nanohybrid Particles and a RGO/Co3O4/Poly(vinylidene fluoride) Composite with Enhanced Wave-Absorption Properties

Fabrication of Reduced Graphene Oxide (RGO)/Co3O4 Nanohybrid Particles and a RGO/Co3O4/Poly(vinylidene fluoride) Composite with Enhanced Wave-Absorption Properties

Soaking it up: RGO/Co3O4 nanohybrid particles have been successfully fabricated by using an in situ growth approach under mild wet-chemical conditions (see scheme). From this, RGO/Co3O4/poly(vinylidene fluoride) composites with excellent absorption properties were obtained and characterized.

[Communication]
Guang-Sheng Wang, Yun Wu, Yun-Zhao Wei, Xiao-Juan Zhang, Yong Li, Li-Dong Li, Bo Wen, Peng-Gang Yin, Lin Guo, Mao-Sheng Cao
ChemPlusChem 2014, 79, No. 3, 375. Read article.

Conducting Polypyrrole Nanotube Arrays as an Implant Surface: Fabricated on Biomedical Titanium with Fine-Tunability by Means of Template-Free Electrochemical Polymerization

Conducting Polypyrrole Nanotube Arrays as an Implant Surface: Fabricated on Biomedical Titanium with Fine-Tunability by Means of Template-Free Electrochemical Polymerization

Grass roots: Template-free electrochemical polymerization in phosphate buffer solution has been used to obtain grasslike polypyrrole (PPy) nanowires of low density on titanium (see figure). By introducing a prenucleation film on the titanium, conducting PPy nanotube arrays (CPNAs) of large area were fabricated. The architectures of the CPNAs can be finely tuned between cones and cylinders by changing the electrochemical parameters.

[Full Paper]
Jingwen Liao, Chengyun Ning, Guoxin Tan, Guoxin Ni, Haobo Pan
ChemPlusChem 2014, 79, No. 4, 524. Read article.

Peptide-Nanofiber-Supported Palladium Nanoparticles as an Efficient Catalyst for the Removal of N-Terminus Protecting Groups

Peptide-Nanofiber-Supported Palladium Nanoparticles as an Efficient Catalyst for the Removal of N-Terminus Protecting Groups

Supporting role: Peptide nanofibers have been used as a template for the in situ generation of palladium nanoparticles. Peptide-nanofiber-supported palladium nanoparticles show efficient catalytic activity towards deprotection of N-terminus amino acids and peptides under mild conditions (see figure).

[Full Paper]
Indrajit Maity, Manoj K. Manna, Dnyaneshwar B. Rasale, Apurba K. Das
ChemPlusChem 2014, 79, No. 3, 413. Read article.

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Non-hinge binding: A novel organometallic protein kinase inhibitor scaffold based on a cyclometalated 1,8-phenanthrolin-7(8 H)-one ligand is reported, which binds to the ATP binding site of the protein kinase Pim1 in an unexpected, unusual non-ATP-mimetic fashion without mimicking the hydrogen-bonding interaction of the adenine nucleobase of ATP.

[Communication]
Kathrin Wähler, Katja Kräling, Holger Steuber, Eric Meggers
ChemistryOpen 2013, 2, No. 5-6, 180. Read article.

Solid-State-Trapped Reactive Ammonium Carbamate Self-Derivative Salts of Prolinamide

Solid-State-Trapped Reactive Ammonium Carbamate Self-Derivative Salts of Prolinamide

Trapped within: We report single-crystal characterization of polymorphs of the ammonium carbamate self-derivative salt of prolinamide, and the first crystal structure of prolinamide and of derived products. This study emphasizes the reactivity of carbonated amines in the solid state and opens perspectives for a systematic study of (solid-state) reactions involving these trapped reactive species.

[Full Paper]
Anaëlle Tilborg, Steve Lanners, Bernadette Norberg, Johan Wouters
ChemistryOpen 2013, 2, No. 5-6, 194. Read article.

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI-MS

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI-MS

Simple and effective: A facile procedure for monitoring chemical reactions and characterizing compounds dissolved in ionic liquids is described using the MS/MS technique. Separation of species of interest was carried out using internal electronic gate available in electrospray mass spectrometers, instead of chromatography and extraction. The separation was carried out as a fast (milliseconds) and sustainable (no extra solvents) procedure.

[Full Paper]
Levon L. Khemchyan, Elena A. Khokhlova, Marina M. Seitkalieva, Valentine P. Ananikov
ChemistryOpen 2013, 2, No. 5-6, 208. Read article.

Metastable β-Bi2O3 Nanoparticles with Potential for Photocatalytic Water Purification Using Visible Light Irradiation

Metastable β-Bi2O3 Nanoparticles with Potential for Photocatalytic Water Purification Using Visible Light Irradiation

Water purification with β-Bi2O3: A straightforward synthetic procedure for the synthesis of β-Bi2O3 nanoparticles that offers the potential for gram-scale production is presented. The β-Bi2O3 nanoparticles show high photocatalytic activity and stability in the degradation of typical organic water pollutants under visible light irradiation. These nanoparticles might be promising materials for use in novel water purification systems.

[Full Paper]
Maik Schlesinger, Marcus Weber, Steffen Schulze, Michael Hietschold, Michael Mehring
ChemistryOpen 2013, 2, No. 4, 146. Read article.