Mission Statement

The Asian Chemical Editorial Society (ACES) is an organization of 13 major chemical societies in Asia and the Pacific. It was founded in 2005 as a conglomeration of chemical societies with the mutual aim of creating a modern publishing forum for research in Asia and coordinating future publishing activities.

The participating societies share a commitment to scientific excellence, to publishing ethics, and to the highest standards in publication, which are the basis for the success of Chemistry—An Asian Journal and its associated journals.

Publications

Chemistry—An Asian Journal

A sister journal of Angewandte Chemie and Chemistry—A European Journal

Supporting Organizations: ChemPubSoc Europe, Gesellschaft Deutscher Chemiker (German Chemical Society, GDCh), Federation of Asian Chemical Societies (FACS).

Asian Journal of Organic Chemistry

A sister journal of the European Journal of Organic Chemistry

For the publication of the AsianJOC, ACES is joined by the Korean Society of Organic Synthesis.

Supporting Organization: ChemPubSoc Europe

ACES supports the publication of the ChemPubSoc Europe journals Chemistry—A European Journal, the European Journal of Organic Chemistry, and ChemSusChem.

© Wiley-VCH 2012

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Chem Asian J

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Asian J Org Chem

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Angew Chem

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Chem Eur J

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Eur J Org Chem

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ChemSusChem

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Chem Rec

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News

Editorials: New Developments

Chemistry - An Asian Journal Theresa Kueckmann
A Good Year
Chem. Asian J. 2014 9, 4.

Asian Journal of Organic ChemistryRichard Threlfall
There's an App for That
Asian J. Org. Chem. 2014 3, 3.

 

Research of the DayEditors' Choice: Spotlights

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Asymmetric Catalysis Mediated by the Ligand Sphere of Octahedral Chiral-at-Metal Complexes

Asymmetric Catalysis Mediated by the Ligand Sphere of Octahedral Chiral-at-Metal Complexes

“Organocatalysis” with metal complexes: Inert octahedral metal complexes are an emerging class of catalysts for asymmetric synthesis. In these compounds the globular, rigid nature and stereochemical options of octahedral compounds are exploited. Complexes like those shown promise new opportunities in the field of catalysis.

[Minireview]
Lei Gong, Liang-An Chen, Eric Meggers
Angew. Chem. Int. Ed. 2014, 53, No. 41, 10868. Read article.

N-Heterocyclic Carbene, High Oxidation State Molybdenum Alkylidene Complexes: Functional-Group-Tolerant Cationic Metathesis Catalysts

N-Heterocyclic Carbene, High Oxidation State Molybdenum Alkylidene Complexes: Functional-Group-Tolerant Cationic Metathesis Catalysts

To be or not to be (cationic)? In the presence of monomer, neutral 16-electron N-heterocyclic carbene adducts of high oxidation state MoVI N-arylimidoalkylidene bis(triflate) complexes convert into cationic 16-electron complexes that are active and functional-group tolerant polymerization catalysts.

[Communication]
Michael R. Buchmeiser, Suman Sen, Jörg Unold, Wolfgang Frey
Angew. Chem. Int. Ed. 2014, 53, No. 35, 9384. Read article.

Metastable Ionic Diodes Derived from an Amine-Based Polymer of Intrinsic Microporosity

Metastable Ionic Diodes Derived from an Amine-Based Polymer of Intrinsic Microporosity

Ionic flip-flop: Polymers with intrinsic microporosity introduce ionic diode and metastable switching effects as a result of their rigid backbone and molecular-structure-dependent anion versus cation conductivity.

[Communication]
Elena Madrid, Yuanyang Rong, Mariolino Carta, Neil B. McKeown, Richard Malpass-Evans, Gary A. Attard, Tomos J. Clarke, Stuart H. Taylor, Yi-Tao Long, Frank Marken
Angew. Chem. Int. Ed. 2014, 53, No. 40, 10751. Read article.

An Efficient Tin-Free Route to Small Molecules Based on Silole-Modified Pentathiophenes for Solution-Processed Organic Solar Cells

An Efficient Tin-Free Route to Small Molecules Based on Silole-Modified Pentathiophenes for Solution-Processed Organic Solar Cells

Catch the sun: Two solution-processable donor-acceptor (D-A) structured organic small molecules based on silole-modified pentathiophene (SiPTA) as the donor unit and diketopyrrolopyrrole (DPP) as the acceptor unit, DPP2(SiPTA) and DPP-SiPTA, were synthesized. The D-A structure and molecular symmetry can significantly tailor energy levels and crystallization, respectively. Solar cells based on DPP2(SiPTA) have power conversion efficiencies of 2.36 %.

[Full Paper]
Qing-Cai Yu, Wei-Fei Fu, Hong-Yu Wang, Xiao-Feng Wu, Jun-Hua Wan, Min-Min Shi, Hong-Zheng Chen
Asian J. Org. Chem. 2014, 3, No. 9, 984. Read article.

Application of Regio- and Stereoselective Functional Group Transformations of Chiral Aziridine-2-carboxylates

Application of Regio- and Stereoselective Functional Group Transformations of Chiral Aziridine-2-carboxylates

Boxing clever: This Focus Review highlights the chemistry of chiral aziridine-2-carboxylates as building blocks based on regio- and stereoselective functional group transformations of the carboxylate group and aziridine ring. This chemistry is exemplified by the efficient and highly stereoselective synthesis of many biologically important amines, including several natural products.

[Focus Review]
Hyun-Joon Ha, Jae-Hoon Jung, Won Koo Lee
Asian J. Org. Chem. 2014, 3, No. 10, 1020. Read article.

Domino Knoevenagel Condensation/Aza-Ene Addition/N-Cyclization Route to Functionalized Imidazo[1,2-a]pyridines and Pyrido[1,2-a]pyrimidines

Domino Knoevenagel Condensation/Aza-Ene Addition/N-Cyclization Route to Functionalized Imidazo[1,2-a]pyridines and Pyrido[1,2-a]pyrimidines

One-pot wonder! The syntheses of imidazo[1,2-a]pyridines and pyrido[1,2-a]pyrimidines were carried out by using a one-pot three-component protocol. The reaction proceeds in a single step through a domino Knoevenagel condensation/aza-ene addition/imine–enamine tautomerization/chemoselective N-cyclization sequence of reactions (In=indolyl).

[Full Paper]
Sathiyamoorthi Sivakumar, Raju Ranjith Kumar
Asian J. Org. Chem. 2014, 3, No. 9, 974. Read article.

Use of Graphite as a Highly Reversible Electrode with Superior Cycle Life for Sodium-Ion Batteries by Making Use of Co-Intercalation Phenomena

Use of Graphite as a Highly Reversible Electrode with Superior Cycle Life for Sodium-Ion Batteries by Making Use of Co-Intercalation Phenomena

In contrast to the general view, graphite can be used as an electrode material in sodium-ion batteries by taking advantage of the formation of ternary graphite intercalation compounds. The important features of this electrode reaction are the small irreversible capacity, the low overpotentials, and the superior cycle life. With a capacity close to 100 mAh g−1, the electrode is attractive for stationary applications.

[Communication]
Birte Jache, Philipp Adelhelm
Angew. Chem. Int. Ed. 2014, 53, No. 38, 10169. Read article.

Upward Trend in Catalytic Efficiency of Rare-Earth Triflate Catalysts in Friedel–Crafts Aromatic Sulfonylation Reactions

Upward Trend in Catalytic Efficiency of Rare-Earth Triflate Catalysts in Friedel–Crafts Aromatic Sulfonylation Reactions

Going up! The upward trend in efficiency of lanthanide (Ln) triflates in catalyzing aromatic sulfonylation reaction correlates with the lanthanide sequence in the periodic table. Various related physical properties of lanthanide ions were found to have some influence on the catalytic activity.

[Full Paper]
Vo Thu An Nguyen, Fritz Duus, Thach Ngoc Le
Asian J. Org. Chem. 2014, 3, No. 9, 963. Read article.

Vitamin B1-Catalyzed Acetoin Formation from Acetaldehyde: A Key Step for Upgrading Bioethanol to Bulk C4 Chemicals

Vitamin B1-Catalyzed Acetoin Formation from Acetaldehyde: A Key Step for Upgrading Bioethanol to Bulk C4 Chemicals

Take your vitamins: A highly selective process for the conversion of bioethanol to C4 bulk chemicals, such as 2,3-butanediol and butene, is reported. The process involves the use of a vitamin B1 (thiamine)-derived N-heterocyclic carbene (NHC)-catalyzed acetoin condensation as the key step to assemble two C2 acetaldehydes into a C4 product. The environmentally benign and cheap natural catalyst vitamin B1 demonstrates high selectivity, high efficiency, and high tolerance toward ethanol and water impurities in the acetoin reaction.

[Communication]
Ting Lu, Xiukai Li, Liuqun Gu, Yugen Zhang
ChemSusChem 2014, 7, No. 9, 2423. Read article.

Metal Nanoparticles and Supramolecular Macrocycles: A Tale of Synergy

Metal Nanoparticles and Supramolecular Macrocycles: A Tale of Synergy

Nanoparticles and macrocycles: Recent literature regarding the combination of supramolecular macrocycles and metal nanoparticles is reviewed, with particular emphasis on the synthesis, surface modification and assembly, as well as the potential applications of the obtained nanocomposites (SERS = surface-enhanced Raman spectroscopy).

[Minireview]
Verónica Montes-García, Jorge Pérez-Juste, Isabel Pastoriza-Santos, Luis M. Liz-Marzán
Chem. Eur. J. 2014, 20, No. 35, 10874. Read article.

Chiral Room Temperature Ionic Liquids as Enantioselective Promoters for the Asymmetric Aldol Reaction

Chiral Room Temperature Ionic Liquids as Enantioselective Promoters for the Asymmetric Aldol Reaction

Chiral ionic liquids derived from natural amino acids are shown to be efficient solvents or additives for direct asymmetric aldol reactions. A match/mismatch effect between the configuration of the chiral ionic liquid and that of proline has been observed, with a higher enantioselectivity obtained for the (S)-proline/CIL 2 complex.

[Full Paper]
Laura González, Jorge Escorihuela, Belén Altava, M. Isabel Burguete, Santiago V. Luis
Eur. J. Org. Chem. 2014, No. 24, 5356. Read article.

Recognition of the DNA Minor Groove by Thiazotropsin Analogues

Recognition of the DNA Minor Groove by Thiazotropsin Analogues

A snug fit: How does ligand–ligand affinity influence sequence-specific molecular recognition for the DNA minor groove? Energetic, structural and assembly characteristics for three related ligands and their cognate DNA recognition complexes were compared by NMR spectroscopy and ITC. Careful engineering of ligands can modify physicochemical properties such as aggregation characteristics without compromising DNA binding ability.

[Full Paper]
Hasan Y. Alniss , Marie-Virginie Salvia, Mykhailo Sadikov, Igor Golovchenko, Nahoum G. Anthony, Abedawn I. Khalaf, Simon P. MacKay, Colin J. Suckling, John A. Parkinson
ChemBioChem 2014, 15, No. 13, 1978. Read article.

Mono- and Bis(pyrrolo)tetrathiafulvalene Derivatives Tethered to C60: Synthesis, Photophysical Studies, and Self-Assembled Monolayers

Mono- and Bis(pyrrolo)tetrathiafulvalene Derivatives Tethered to C60: Synthesis, Photophysical Studies, and Self-Assembled Monolayers

Communication breakdown: Dyads and triads composed of fullerenes and pyrrolotetrathiafulvalenes were prepared by Prato cycloaddition reactions and subjected to detailed electrochemical and photophysical studies, including absorption and fluorescence spectroscopy, as well as femtosecond and nanosecond transient absorption studies, which indicated no observable electronic communication between the tetrathiafulvalene and the C60 moieties (see figure). The dyad and triad molecules form self-assembled monolayers on gold surfaces.

[Full Paper]
Marta Vico Solano, Eduardo Antonio Della Pia, Martyn Jevric, Christina Schubert, Xintai Wang, Cornelia van der Pol, Anders Kadziola, Kasper Nørgaard, Dirk M. Guldi, Mogens Brøndsted Nielsen, Jan O. Jeppesen
Chem. Eur. J. 2014, 20, No. 32, 9918. Read article.

Chemocatalytic Upgrading of Tailored Fermentation Products Toward Biodiesel

Chemocatalytic Upgrading of Tailored Fermentation Products Toward Biodiesel

Free upgrade: By tailoring both biological and chemocatalytic processes, the production of sustainable biodiesel from lignocellulosic sugar is maximized. Hydrotalcite-supported copper(II) and palladium(0) catalysts are combined with a modification of the process of fermentation of acetone–butanol–ethanol to isopropanol–butanol–ethanol, producing higher concentrations of diesel-range components in the alkylation reaction.

[Communication]
Sanil Sreekumar, Zachary C. Baer, Elad Gross, Sasisanker Padmanaban, Konstantinos Goulas, Gorkem Gunbas, Selim Alayoglu, Harvey W. Blanch, Douglas S. Clark, F. Dean Toste
ChemSusChem 2014, 7, No. 9, 2445. Read article.

Determination of the Stereostructure of Pyrimidine Nucleoside Derivatives with a Combination of Various Chiroptical Methods

Determination of the Stereostructure of Pyrimidine Nucleoside Derivatives with a Combination of Various Chiroptical Methods

The absolute configuration of pyrimidine nucleoside derivatives obtained by enantioselective reduction was determined using a combination of electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopy in tandem with quantum chemical calculations.

[Full Paper]
Marcin Górecki, Aleksandra Karczmarska-Wódzka, Renata Kołodziejska, Marcin Dramiński, Jadwiga Frelek
Eur. J. Org. Chem. 2014, No. 24, 5204. Read article.

Aerobic Oxidation of Alkylaromatics using a Lipophilic N-Hydroxyphthalimide: Overcoming the Industrial Limit of Catalyst Solubility

Aerobic Oxidation of Alkylaromatics using a Lipophilic N-Hydroxyphthalimide: Overcoming the Industrial Limit of Catalyst Solubility

Lipophilic and selective: A new lipophilic analogous of N-hydroxyphthalimide, operating with reduced amounts of polar cosolvent, reaches the goal of promoting the aerobic oxidation of alkylaromatics to the corresponding hydroperoxides with good yields and high selectivity. The catalyst is selected on the basis of a study on the influence of substituents on the aromatic ring of N-hydroxyphthalimide.

[Full Paper]
Manuel Petroselli, Paola Franchi, Marco Lucarini, Carlo Punta, Lucio Melone
ChemSusChem 2014, 7, No. 9, 2695. Read article.

Structural Insights into Enzymatic Degradation of Oxidized Polyvinyl Alcohol

Structural Insights into Enzymatic Degradation of Oxidized Polyvinyl Alcohol

Crystal-clear hydrolysis: The crystal structures of OPH with bound inhibitors from two PVA-degrading microbes were analyzed to elucidate the hydrolytic mechanism of oxi-PVA. Several site-directed mutants were also constructed to enhance the OPH activity.

[Communication]
Yu Yang, Tzu-Ping Ko, Long Liu, Jianghua Li, Chun-Hsiang Huang, Hsiu-Chien Chan, Feifei Ren, Dongxu Jia, Andrew H.-J. Wang, Rey-Ting Guo, Jian Chen, Guocheng Du
ChemBioChem 2014, 15, No. 13, 1882. Read article.

Rationalizing the Structural Variability of the Exocyclic Amino Groups in Nucleobases and Their Metal Complexes: Cytosine and Adenine

Rationalizing the Structural Variability of the Exocyclic Amino Groups in Nucleobases and Their Metal Complexes: Cytosine and Adenine

Hybridization and structure of exocyclic amino groups of cytosine and adenine nucleobases can shift from sp2 to sp3 (see graphic) if an amino proton acts as a donor in a strong hydrogen-bonding interaction or if it is replaced by a monofunctionally bonded metal ion.

[Communication]
Célia Fonseca Guerra, Pablo J. Sanz Miguel, Andrea Cebollada, F. Matthias Bickelhaupt, Bernhard Lippert
Chem. Eur. J. 2014, 20, No. 31, 9494. Read article.

The Side Chain Makes the Difference: Investigation of the 2D Self-Assembly of 1,3,5-Tris[4-(4-pyridinyl)phenyl]benzene Derivatives by Scanning Tunneling Microscopy

The Side Chain Makes the Difference: Investigation of the 2D Self-Assembly of 1,3,5-Tris[4-(4-pyridinyl)phenyl]benzene Derivatives by Scanning Tunneling Microscopy

A series of star-shaped compounds with different pyridine end groups is prepared, and the 2D self-assembly of these compounds is investigated by scanning tunneling microscopy (STM). Small variations in the substitution pattern lead to remarkably different self-assembly behavior. A reduction of the symmetry of the compounds has a particularly strong effect on the self-assembly result.

[Full Paper]
Daniel Trawny, Lucie Vandromme, Jürgen P. Rabe, Hans-Ulrich Reissig
Eur. J. Org. Chem. 2014, No. 23, 4985. Read article.

Genetic Encoding of Caged Cysteine and Caged Homocysteine in Bacterial and Mammalian Cells

Genetic Encoding of Caged Cysteine and Caged Homocysteine in Bacterial and Mammalian Cells

Photochemical OFF→ON switching of proteins: Caged cysteine and caged homocysteine were genetically incorporated into proteins in bacterial and mammalian cells, allowing photochemical control over the activity of these proteins and thus offering the potential for precise spatial and temporal regulation of a wide range of cellular processes.

[Full Paper]
Rajendra Uprety, Ji Luo, Jihe Liu, Yuta Naro, Subhas Samanta, Alexander Deiters
ChemBioChem 2014, 15, No. 12, 1793. Read article.

Synthesis and Photophysics of a Red-Light Absorbing Supramolecular Chromophore System

Synthesis and Photophysics of a Red-Light Absorbing Supramolecular Chromophore System

Dye dyad design: The fusion of a naphthalene diimide dye to a zinc–bis-salicylimide phenylene (salphen; see figure) moiety creates an expanded red-light absorbing chromophore with an embedded metal atom for supramolecular interaction with substituted pyridines. A column-chromatography-free preparation of this novel scaffold is described and its photophysical properties are analyzed, which compare favorably with the widely used supramolecular light-harvester zinc tetraphenylporphyrin.

[Full Paper]
Jeroen A. Rombouts, Janneke Ravensbergen, Raoul N. Frese, John T. M. Kennis, Andreas W. Ehlers, J. Chris Slootweg, Eelco Ruijter, Koop Lammertsma, Romano V. A. Orru
Chem. Eur. J. 2014, 20, No. 33, 10285. Read article.

Solid-Phase Synthesis of Cyclic Lipopeptidotriazoles

Solid-Phase Synthesis of Cyclic Lipopeptidotriazoles

An efficient methodology for the solid-phase synthesis of cyclic lipopeptidotriazoles involving the use of five orthogonal protecting groups has been established. This strategy has been used to prepare a set of derivatives of the antimicrobial cyclic peptide BPC194 in high purities.

[Full Paper]
Sílvia Vilà, Cristina Camó, Eduard Figueras, Esther Badosa, Emilio Montesinos, Marta Planas, Lidia Feliu
Eur. J. Org. Chem. 2014, No. 22, 4785. Read article.

Sequence Elements Distal to the Ligand Binding Pocket Modulate the Efficiency of a Synthetic Riboswitch

Sequence Elements Distal to the Ligand Binding Pocket Modulate the Efficiency of a Synthetic Riboswitch

The structure–function relationship of a U-turn motif in the terminal loop of a synthetic neomycin riboswitch has been investigated. The analysis revealed those nucleobases required to optimize riboswitch function at every single position. A detailed comparison of functional and inactive mutants revealed a relationship between aptamer dynamics and regulation efficiency.

[Full Paper]
Julia E. Weigand, Sina R. Gottstein-Schmidtke, Shemsi Demolli, Florian Groher, Elke Duchardt-Ferner, Jens Wöhnert, Beatrix Suess
ChemBioChem 2014, 15, No. 11, 1627. Read article.

A Hybrid Supercapacitor based on Porous Carbon and the Metal-Organic Framework MIL-100(Fe)

A Hybrid Supercapacitor based on Porous Carbon and the Metal-Organic Framework MIL-100(Fe)

Charged and ready: Composite supercapacitor electrodes based on metal–organic frameworks and carbon nanotubes are tested with environmentally friendly electrolytes. The energy-storage mechanism followed by these materials is explored and explained, and promising results are obtained with the electrodes.

[Article]
Nicolò Campagnol, Ricardo Romero-Vara, Willem Deleu, Linda Stappers, Koen Binnemans, Dirk E. De Vos, Jan Fransaer
ChemElectroChem 2014, 1, No. 7, 1182. Read article.

Electron Transport Characteristics of the Dimeric 1,4-Benzenedithiol Junction

Electron Transport Characteristics of the Dimeric 1,4-Benzenedithiol Junction

At an important junction: Scanning tunneling microscopy and quantum chemistry calculations were combined to probe the conductivity of the dimeric 1,4-benzenedithiol (BDT) junction. The dihedral angle of the S-S bond tends to take a perpendicular conformation, which breaks the conjugated structure and localizes the electron distribution.

[Communication]
Lin Wang, Shu-Ying Li, Jing-He Yuan, Jing-Ying Gu, Dong Wang, Li-Jun Wan
Chem. Asian J. 2014, 9, No. 8, 2077. Read article.

Direct Synthesis of Hexagonal NaGdF4 Nanocrystals from a Single-Source Precursor: Upconverting NaGdF4:Yb3+,Tm3+ and Its Composites with TiO2 for Near-IR-Driven Photocatalysis

Direct Synthesis of Hexagonal NaGdF4 Nanocrystals from a Single-Source Precursor: Upconverting NaGdF4:Yb3+,Tm3+ and Its Composites with TiO2 for Near-IR-Driven Photocatalysis

Up, up, and away! Using a novel single-source precursor, the most efficient hexagonal phase of the upconverting NaGdF4:Yb3+,Tm3+ nanocrystals was obtained under mild conditions. These nanocrystals were used to form a composite with TiO2 as a new photocatalyst, enabling titania to extend its absorption range from ultraviolet to the near-infrared region.

[Communication]
Ying Chen, Shashank Mishra, Gilles Ledoux, Erwann Jeanneau, Marlene Daniel, Jinlong Zhang, Stéphane Daniele
Chem. Asian J. 2014, 9, No. 9, 2415. Read article.

Multielectron, Multistep Molecular Catalysis of Electrochemical Reactions: Benchmarking of Homogeneous Catalysts

Multielectron, Multistep Molecular Catalysis of Electrochemical Reactions: Benchmarking of Homogeneous Catalysts

Off the bench: Rational benchmarking of molecular catalysts entails comparing their catalytic Tafel plots within the same log(turnover frequency) versus overpotential plane of merit.

[Article]
Cyrille Costentin, Jean-Michel Savéant
ChemElectroChem 2014, 1, No. 7, 1226. Read article.

Synthesis, σ Receptor Affinity, and Pharmacological Evaluation of 5-Phenylsulfanyl- and 5-Benzyl-Substituted Tetrahydro-2-benzazepines

Synthesis, σ Receptor Affinity, and Pharmacological Evaluation of 5-Phenylsulfanyl- and 5-Benzyl-Substituted Tetrahydro-2-benzazepines

Size matters: A set of 5-phenylsulfanyl- and 5-benzyl-substituted tetrahydro-2-benzazepines was synthesized by the novel strategy of connecting C6–C1 and C3–N building blocks. Diverse N substituents were introduced, and the compounds were pharmacologically evaluated. High σ1 receptor affinity was observed for 2-benzazepines with N substituents larger than a linear propyl group. The N-(4-fluorobenzyl)-substituted derivative is a promising starting point for development of σ1 ligands with cognition-enhancing and analgesic activity.

[Full Paper]
Peer Hasebein, Bastian Frehland, Dirk Schepmann, Bernhard Wünsch
ChemMedChem 2014, 9, No. 8, 1697. Read article.

The Effect of Water on the Heterogeneously Catalyzed Selective Oxidation of Acrolein: An Isotope Study

The Effect of Water on the Heterogeneously Catalyzed Selective Oxidation of Acrolein: An Isotope Study

A wisdom mix: The effect of water on the partial oxidation of acrolein on Mo/V/W mixed oxides is studied. The incorporation of oxygen originating from water into acrolein and oxidation products is investigated by performing isotope exchange experiments.

[Full Paper]
Tina Petzold, Nina Blickhan, Alfons Drochner, Herbert Vogel
ChemCatChem 2014, 6, No. 7, 2053. Read article.

Stereoselective Transformations of α-Trifluoromethylated Ketoximes to Optically Active Amines by Enzyme–Nanometal Cocatalysis: Synthesis of (S)-Inhibitor of Phenylethanolamine N-Methyltransferase

Stereoselective Transformations of α-Trifluoromethylated Ketoximes to Optically Active Amines by Enzyme–Nanometal Cocatalysis: Synthesis of (S)-Inhibitor of Phenylethanolamine N-Methyltransferase

No inhibitions: One-pot cascade chemoenzymatic synthesis of chiral α-trifluoromethylated amines from ketoximes is performed by using catalysts prepared by atomic-layer deposition (ALD) method combined with Candida antarctica lipase B. The obtained amine was treated as an important raw material for total synthesis of an (S)-inhibitor of phenylethanolamine N-methyltransferase (PNMT).

[Full Paper]
Guilin Cheng, Qi Wu, Zeyu Shang, Xinhua Liang, Xianfu Lin
ChemCatChem 2014, 6, No. 7, 2129. Read article.

Towards a Zero-Waste Oxidative Coupling of Nonactivated Aromatics by Supported Gold Nanoparticles

Towards a Zero-Waste Oxidative Coupling of Nonactivated Aromatics by Supported Gold Nanoparticles

No more waste: Supported gold nanoparticles catalyze the coupling of unactivated arenes in O2 without the typical need of iodine oxidants, acids, bases, or additional metal salts in solution to result in a zero-waste synthetic process. This is in contrast to other catalysts that can perform for only a few turnovers and produce large quantities of waste.

[Communication]
Pedro Serna, Avelino Corma
ChemSusChem 2014, 7, No. 8, 2136. Read article.

Specificity of Light-Induced Covalent Adduct Formation between RuII Oligonucleotide Conjugates and Target Sequences for Gene Silencing Applications

Specificity of Light-Induced Covalent Adduct Formation between RuII Oligonucleotide Conjugates and Target Sequences for Gene Silencing Applications

Under irradiation, a Ru–TAP (TAP = 1,4,5,8-tetraazaphenanthrene) complex linked to an oligonucleotide (violet) hybridized with its complementary sequence (green) is covalently anchored specifically to the G bases of the complementary sequence and not the G bases along its own sequence.

[Full Paper]
Lionel Marcélis, Mathieu Surin, Rémy Lartia, Cécile Moucheron, Eric Defrancq, Andrée Kirsch-De Mesmaeker
Eur. J. Inorg. Chem. 2014, No. 19, 3016. Read article.

Production of Nanostructured Conjugated Polymers by Electropolymerization of Tailored Tetrahedral Precursors

Production of Nanostructured Conjugated Polymers by Electropolymerization of Tailored Tetrahedral Precursors

The long ranger: Transmission electron microscopy analysis of the material produced by the potentiostatic electropolymerization of a rigid, highly symmetrical, slender precursor with four reactive 3-methoxythiophene end-groups provides evidence for the formation of organized nanostructures.

[Article]
Ali Yassin, Romain Mallet, Philippe Leriche, Jean Roncali
ChemElectroChem 2014, 1, No. 7, 1219. Read article.

Synthesis of Water-Dispersible Boron Nitride Nanoparticles

Synthesis of Water-Dispersible Boron Nitride Nanoparticles

Small-sized hexagonal boron nitride (h-BN) nanoparticles have been synthesized. Copper oxide plays a role in changing the surface properties of h-BN nanoparticles and improving their aqueous dispersibility. The h-BN nanoparticles can be well dispersed and are stable in aqueous solution.

[Full Paper]
Chengjia Xiong, Weixia Tu
Eur. J. Inorg. Chem. 2014, No. 19, 3010. Read article.

Aminoferrocene and Ferrocene Amino Acid as Electron Donors in Modular Porphyrin–Ferrocene and Porphyrin–Ferrocene–Porphyrin Conjugates

Aminoferrocene and Ferrocene Amino Acid as Electron Donors in Modular Porphyrin–Ferrocene and Porphyrin–Ferrocene–Porphyrin Conjugates

Porphyrin–ferrocene dyads and porphyrin–ferrocene–porphyrin tweezers with tuneable electron density at the porphyrin arms and ferrocene cores are prepared, and the reductive photoinduced electron transfer from ferrocene to the electronically excited porphyrins is investigated. Singlet–singlet energy transfer between the porphyrin arms in the tweezers is also feasible in a V-shaped conformation.

[Full Paper]
Jascha Melomedov, Julian Robert Ochsmann, Michael Meister, Frédéric Laquai, Katja Heinze
Eur. J. Inorg. Chem. 2014, No. 18, 2902. Read article.

Methane Steam Reforming over a Ni/NiAl2O4 Model Catalyst—Kinetics

Methane Steam Reforming over a Ni/NiAl2O4 Model Catalyst—Kinetics

Kinetics change: A detailed investigation of methane steam reforming over a nickel catalyst is performed at steam-to-carbon (S/C) ratios of 0.2–7.1 at 843, 858, and 873 K. Kinetic orders (red for high and blue for low values) of the reactants change as a function of S/C. The background color represents steam and the color of the symbols methane kinetic order. The actual position of the symbols represents the steam conversion rate as a function of S/C.

[Full Paper]
Christoph Sprung, Bjørnar Arstad, Unni Olsbye
ChemCatChem 2014, 6, No. 7, 1969. Read article.

Nickel–Copper/Gadolinium-Doped Ceria (CGO) Composite Electrocatalyst as a Protective Layer for a Solid-Oxide Fuel Cell Anode Fed with Ethanol

Nickel–Copper/Gadolinium-Doped Ceria (CGO) Composite Electrocatalyst as a Protective Layer for a Solid-Oxide Fuel Cell Anode Fed with Ethanol

Shielded: A nickel–copper alloy is mixed with gadolinium-doped ceria to obtain an anode-supported solid-oxide fuel cell (AS-SOFC) modified with a protective layer coated on the anode (see picture; YSZ = Y0.08Zr0.92O2, YDC = Y0.10Ce0.90O2, LSFCO = La0.6Sr0.4Fe0.8Co0.2O3). A comparative study between the modified cell and a conventional AS-SOFC without the protective layer is performed.

[Article]
Massimiliano Lo Faro, Rafael M. Reis, Guilherme G. A. Saglietti, Andre G. Sato, Edson A. Ticianelli, Sabrina C. Zignani, Antonio S. Aricò
ChemElectroChem 2014, 1, No. 8, 1395. Read article.

Dissipative Particle Dynamics Simulation Study on Vesicles Self-Assembled from Amphiphilic Hyperbranched Multiarm Copolymers

Dissipative Particle Dynamics Simulation Study on Vesicles Self-Assembled from Amphiphilic Hyperbranched Multiarm Copolymers

Normal or the reverse: The formation mechanism and dynamics of both normal and reverse branched polymersomes from hyperbranched multiarm copolymers were studied in detail through dissipative particle dynamics simulations. A “unimers-to-spheres-to-membranes-to-vesicles” pathway without rod intermediates is disclosed. In addition, the bilayer or monolayer molecular packing models and microphase separation behaviors of these vesicles were also studied and compared.

[Full Paper]
Yuling Wang, Bin Li, Haibao Jin, Yongfeng Zhou, Zhongyuan Lu, Deyue Yan
Chem. Asian J. 2014, 9, No. 8, 2281. Read article.

Disilanyl Double-Pillared Bisternaphthyl (SiDPBT): Synthesis and Interfused Packing Structures with Herringbone and π-Stack Motifs

Disilanyl Double-Pillared Bisternaphthyl (SiDPBT): Synthesis and Interfused Packing Structures with Herringbone and π-Stack Motifs

Packed in like herrings: A cyclophane molecule with disilanyl pillars was synthesized by using ternaphthyl as base arylene units to afford a macrocycle possessing interfused packing structures of π-stack and herringbone motifs.

[Communication]
Waka Nakanishi, Naoto Matsuyama, Daisuke Hara, Akinori Saeki, Shunpei Hitosugi, Shu Seki, Hiroyuki Isobe
Chem. Asian J. 2014, 9, No. 7, 1782. Read article.

Annulation of Phenols: Catalytic Behavior of Conventional and 2 D Zeolites

Annulation of Phenols: Catalytic Behavior of Conventional and 2 D Zeolites

Ideal for bulky substrates: Catalytic behavior of hierarchical MFI zeolites was investigated in annulation reaction of phenols differing in size with methylbutenol and compared with that of medium and large-pore zeolites MFI and BEA.

[Full Paper]
Maksym V. Opanasenko, Mariya V. Shamzhy, Changbum Jo, Ryong Ryoo, Jirí Čejka
ChemCatChem 2014, 6, No. 7, 1919. Read article.

Ergoline-Derived Inverse Agonists of the Human H3 Receptor for the Treatment of Narcolepsy

Ergoline-Derived Inverse Agonists of the Human H3 Receptor for the Treatment of Narcolepsy

Time to wake up! Histamine H3 receptor (H3R) inverse agonism is a well-established paradigm for the treatment of narcolepsy. Unfortunately, all drug candidates so far proved to have a long duration of action, causing insomnia on the following night. The chance discovery of a novel, ergoline-based scaffold opens a new avenue towards derivatives that exhibit potent, but short-acting, inhibition of H3R.

[Full Paper]
Yves P. Auberson, Thomas Troxler, Xuechun Zhang, Charles R. Yang, Markus Fendt, Dominik Feuerbach, Yu-Chih Liu, Bharat Lagu, Andreas Lerchner, Mark Perrone, Lijun Lei, Chao Zhang, Chunxiu Wang, Tie-Lin Wang, Mark G. Bock
ChemMedChem 2014, 9, No. 8, 1683. Read article.

3-(2-Oxoethylidene)indolin-2-one Derivatives Activate Nrf2 and Inhibit NF-κB: Potential Candidates for Chemoprevention

3-(2-Oxoethylidene)indolin-2-one Derivatives Activate Nrf2 and Inhibit NF-κB: Potential Candidates for Chemoprevention

Better than ‘Super’: Compounds that elicit cytoprotective and anti-inflammatory effects are promising candidates for chemoprevention. Analogues of 1-methyl-3-(2-oxopropylidene)indolin-2-one (‘supercinnamaldehyde’) were synthesized and evaluated for their ability to induce Nrf2-mediated cytoprotection and suppress NF-κB-directed inflammation. Lead compound 6 (R1: Me; R2: Ph), with the supercinnamaldehyde scaffold, has the potential to yield derivatives with even greater chemopreventive activity.

[Full Paper]
Amrita A. Nagle, Shridhivya A. Reddy, Helene Bertrand, Hisashi Tajima, Truong-Minh Dang, Siew-Cheng Wong, John D. Hayes, Geoffrey Wells, Eng-Hui Chew
ChemMedChem 2014, 9, No. 8, 1763. Read article.

Alkenyl-Alkynylgermanes Functionalised by Lewis Acids: Intramolecular Aluminium– and Gallium–Alkyne Interactions and Potential Ge–C Bond Activation

Alkenyl-Alkynylgermanes Functionalised by Lewis Acids: Intramolecular Aluminium– and Gallium–Alkyne Interactions and Potential Ge–C Bond Activation

Bond activation by intramolecular interactions of alkynyl carbon with highly Lewis acidic aluminium atoms was observed for functionalised alkenyl-alkynylgermanes. Such mixed germanium–aluminum or –gallium compounds were obtained by hydrometallation of dialkynylgermanes and are promising candidates for secondary reactions such as cyclisation or insertion.

[Full Paper]
Werner Uhl, Stefan Pelties, Martina Rohling, Jens Tannert
Eur. J. Inorg. Chem. 2014, No. 17, 2809. Read article.

Dinuclear Platinum Complexes Containing Planar Aromatic Ligands to Enhance Stacking Interactions with Proteins

Dinuclear Platinum Complexes Containing Planar Aromatic Ligands to Enhance Stacking Interactions with Proteins

The life of π: Pt-based quinoline and benzothiazole complexes were synthesized with an aim to design drugs with higher affinity for π–π stacking and electrostatic interactions with targeted biomolecules. Fluorescence spectroscopy and molecular modeling led to candidate complexes with significant cytotoxicity toward various tumor cell lines.

[Full Paper]
Erin S. F. Ma, A. Gerard Daniel, Nicholas P. Farrell
ChemMedChem 2014, 9, No. 6, 1155. Read article.

Interphase Evolution at Two Promising Electrode Materials for Li-Ion Batteries: LiFePO4 and LiNi1/2Mn1/2O2

Interphase Evolution at Two Promising Electrode Materials for Li-Ion Batteries: LiFePO4 and LiNi1/2Mn1/2O2

The importance of the chemical history of the electrode surface before electrochemical cycling as well as the correlation between interface phenomena, the formation/evolution of an interphase, and the electrochemical behavior of LiFePO4 and LiNi1/2Mn1/2O2 electrodes are investigated by magic-angle-spinning nuclear magnetic resonance, electron energy loss spectroscopy, and X-ray photoelectron spectroscopy. These techniques allow the study of interface aging and failure mechanisms.

[Review]
Nicolas Dupré, Marine Cuisinier, Jean-Frederic Martin, Dominique Guyomard
ChemPhysChem 2014, 15, No. 10, 1922. Read article.

Magnetic Resonance Imaging of Electrochemical Cells Containing Bulk Metal

Magnetic Resonance Imaging of Electrochemical Cells Containing Bulk Metal

Caught on film: Magnetic resonance imaging (MRI) is common in medical research and, more recently, is being applied to visualize chemical composition, molecular transport, and physical environment in engineering and materials research. Researchers are now starting to use these techniques to investigate electrochemical devices.

[Concept]
Melanie M. Britton
ChemPhysChem 2014, 15, No. 9, 1731. Read article.

Far-Red Organic Fluorophores Contain a Fluorescent Impurity

Far-Red Organic Fluorophores Contain a Fluorescent Impurity

A near-red fluorescent impurity is characterized in several commonly used far-red fluorescent dyes. This impurity can lead to artifacts in live-cell multicolor super-resolution measurements, subtle artifacts in chemically fixed cells, and highlights the importance of controls in super-resolution imaging.

[Communication]
Matthew B. Stone, Sarah L. Veatch
ChemPhysChem 2014, 15, No. 11, 2240. Read article.

Electrically Controlled Eight-Spin-Qubit Entangled-State Generation in a Molecular Break Junction

Electrically Controlled Eight-Spin-Qubit Entangled-State Generation in a Molecular Break Junction

Tale of entanglement: An eight-spin-qubit quantum entangled state can be realized in a dinuclear Fe(II) complex which (under a specific set of quantum-logic-gate operations) can act as a source of multi-qubit generation. The large decoherence time with high quantum fidelity factor makes the system an efficient quantum-computing object.

[Communication]
Mausumi Chattopadhyaya, Md. Mehboob Alam, Debasis Sarkar, Swapan Chakrabarti
ChemPhysChem 2014, 15, No. 9, 1747. Read article.

Silica Mineralization by a Peptide Template Having a High Charge Relay Effect

Silica Mineralization by a Peptide Template Having a High Charge Relay Effect

In charge: The influence of the charge relay effects of peptide organic templates on silica mineralization has been investigated. β-Sheet-type peptide shows higher catalytic activity toward the condensation of trimethylsilanol than random-coil peptide (see figure). Silica mineralized on the Val-His-Val-Glu-Val-Ser (VHVEVS) peptide template forms a flat surface, which is affected by the peptide morphology.

[Full Paper]
Kazuki Murai, Masahiro Higuchi, Tatsuya Kuno, Katsuya Kato
ChemPlusChem 2014, 79, No. 4, 531. Read article.

Helical Carbon Segment in Carbon–Boron–Nitride Heteronanotubes: Structure and Nonlinear Optical Properties

Helical Carbon Segment in Carbon–Boron–Nitride Heteronanotubes: Structure and Nonlinear Optical Properties

Helix topological effect: The helix C segment in HA-9 leads to fascinating long-range charge-transfer character. As a result, the β0 value of HA-9 is 1.80×104 a.u., which is clearly larger than that of PA-9 (4.99×103 a.u.). Further investigations show that the larger β0 value of HA-9 is essentially induced by the helix topological effect of the C-segment (see figure).

[Full Paper]
Rong-Lin Zhong, Shi-Ling Sun, Hong-Liang Xu, Yong-Qing Qiu, Zhong-Min Su
ChemPlusChem 2014, 79, No. 5, 732. Read article.

Enhanced Aerobic Epoxidation of Styrene with Copper(II), Cobalt(II), Iron(III), or Oxovanadium(IV) Salen Complexes Immobilized onto Carbon-Coated Fe3O4 Nanoparticles Hybridized with Graphene Sheets

Enhanced Aerobic Epoxidation of Styrene with Copper(II), Cobalt(II), Iron(III), or Oxovanadium(IV) Salen Complexes Immobilized onto Carbon-Coated Fe3O4 Nanoparticles Hybridized with Graphene Sheets

Extra support: Core–shell-structured magnetic nanocatalysts have been prepared and used as efficient heterogeneous catalysts for the aerobic oxidation of styrene. Mildly reduced graphene oxide (MRGO; see picture)/Fe3O4@C–salen–Co showed over 91 % conversion of styrene and over 52 % selectivity to the styrene oxide. The materials can be easily recovered through simple magnetic separation.

[Full Paper]
Zhifang Li, Shujie Wu, Dafang Zheng, Hong Ding, Xiufang Wang, Xiaoyuan Yang, Qisheng Huo, Jingqi Guan, Qiubin Kan
ChemPlusChem 2014, 79, No. 5, 716. Read article.

Influencing the Orientation of Jahn–Teller Axes in Butterfly-Like MnIII4 Clusters

Influencing the Orientation of Jahn–Teller Axes in Butterfly-Like MnIII4 Clusters

In the wings: A bis-phenolate with calixarene character influences the orientation of Jahn–Teller axes (shown by arrows in the figure) in a tetranuclear MnIII cluster. Structural changes and prevailing magnetic properties are presented.

[Communication]
Ross McLellan, Maria A. Palacios, Euan K. Brechin, Scott J. Dalgarno
ChemPlusChem 2014, 79, No. 5, 667. Read article.

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

Non-hinge binding: A novel organometallic protein kinase inhibitor scaffold based on a cyclometalated 1,8-phenanthrolin-7(8 H)-one ligand is reported, which binds to the ATP binding site of the protein kinase Pim1 in an unexpected, unusual non-ATP-mimetic fashion without mimicking the hydrogen-bonding interaction of the adenine nucleobase of ATP.

[Communication]
Kathrin Wähler, Katja Kräling, Holger Steuber, Eric Meggers
ChemistryOpen 2013, 2, No. 5-6, 180. Read article.

Solid-State-Trapped Reactive Ammonium Carbamate Self-Derivative Salts of Prolinamide

Solid-State-Trapped Reactive Ammonium Carbamate Self-Derivative Salts of Prolinamide

Trapped within: We report single-crystal characterization of polymorphs of the ammonium carbamate self-derivative salt of prolinamide, and the first crystal structure of prolinamide and of derived products. This study emphasizes the reactivity of carbonated amines in the solid state and opens perspectives for a systematic study of (solid-state) reactions involving these trapped reactive species.

[Full Paper]
Anaëlle Tilborg, Steve Lanners, Bernadette Norberg, Johan Wouters
ChemistryOpen 2013, 2, No. 5-6, 194. Read article.

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI-MS

Efficient Sustainable Tool for Monitoring Chemical Reactions and Structure Determination in Ionic Liquids by ESI-MS

Simple and effective: A facile procedure for monitoring chemical reactions and characterizing compounds dissolved in ionic liquids is described using the MS/MS technique. Separation of species of interest was carried out using internal electronic gate available in electrospray mass spectrometers, instead of chromatography and extraction. The separation was carried out as a fast (milliseconds) and sustainable (no extra solvents) procedure.

[Full Paper]
Levon L. Khemchyan, Elena A. Khokhlova, Marina M. Seitkalieva, Valentine P. Ananikov
ChemistryOpen 2013, 2, No. 5-6, 208. Read article.

Metastable β-Bi2O3 Nanoparticles with Potential for Photocatalytic Water Purification Using Visible Light Irradiation

Metastable β-Bi2O3 Nanoparticles with Potential for Photocatalytic Water Purification Using Visible Light Irradiation

Water purification with β-Bi2O3: A straightforward synthetic procedure for the synthesis of β-Bi2O3 nanoparticles that offers the potential for gram-scale production is presented. The β-Bi2O3 nanoparticles show high photocatalytic activity and stability in the degradation of typical organic water pollutants under visible light irradiation. These nanoparticles might be promising materials for use in novel water purification systems.

[Full Paper]
Maik Schlesinger, Marcus Weber, Steffen Schulze, Michael Hietschold, Michael Mehring
ChemistryOpen 2013, 2, No. 4, 146. Read article.